Abstract:
:In humans, recombination in the pseudoautosomal region is approximately 10-fold higher in males than in females. This difference is thought to reflect the fact that, in females, there is opportunity for genetic exchange along the entire length of the X chromosome, resulting in a relative reduction in the likelihood of exchange in the pseudoautosomal region. In two instances in the laboratory mouse where X-chromosome pairing and exchange in females are limited to the pseudoautosomal region, a significant level of X-chromosome pairing failure was observed at diakinesis/metaphase I. Further analysis indicated that, in female meiosis, the inability of the X chromosome to consistently form a pairing configuration via the pseudoautosomal region alone is not a property of the pseudoautosomal region per se but is due to the fact that it resides on an X chromosome. Thus previously reported sex-linked differences in recombination rate in the pseudoautosomal region may actually reflect differences in pairing and/or recombination of the pseudoautosomal region on an X chromosome undergoing male versus female meiosis.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Hunt PA,LeMaire Rsubject
Has Abstractpub_date
1992-06-01 00:00:00pages
1162-70issue
6eissn
0002-9297issn
1537-6605journal_volume
50pub_type
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
pub_type: 杂志文章
doi:
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更新日期:2004-02-01 00:00:00
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更新日期:2004-05-01 00:00:00
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journal_title:American journal of human genetics
pub_type: 杂志文章
doi:10.1086/425221
更新日期:2004-11-01 00:00:00
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journal_title:American journal of human genetics
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
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更新日期:1991-09-01 00:00:00
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