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Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.

Abstract：

:Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Huyghe JR,Van Laer L,Hendrickx JJ,Fransen E,Demeester K,Topsakal V,Kunst S,Manninen M,Jensen M,Bonaconsa A,Mazzoli M,Baur M,Hannula S,Mäki-Torkko E,Espeso A,Van Eyken E,Flaquer A,Becker C,Stephens D,Sorri M,Orzan

doi

10.1016/j.ajhg.2008.08.002

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

401-7

issue

3

eissn

0002-9297

issn

1537-6605

journal_volume

83

pub_type

杂志文章

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