Nerve regeneration through a two-ply biodegradable nerve guide in the rat and the influence of ACTH4-9 nerve growth factor.

Abstract:

:Biodegradable polyurethane-based (PU) nerve guides, instilled with or without ACTH4-9 analog (a melanocortin) were used for bridging an 8 mm gap in the rat sciatic nerve and were evaluated for function and histological appearance after 16 weeks of implantation. Autologous nerve grafts functioned as controls. The guides successfully enabled the sciatic nerve to regenerate across the 8 mm gap, thus effectively reestablishing the contact between the proximal and distal nerve ends. The mean conduction velocity, motor latency, and muscle action potentials of all the nerve guides did not differ significantly from the autografts. The histological quality of the regeneration in the nerve guides was significantly better than in the autografts; in the nerve guides, a well-defined nerve cable of normal architecture had regenerated without extensive endoneural scarring as seen in the autografts. ACTH4-9 instilled in the nerve guides showed a slight, but significant, increase in the number of myelinated axons. It is concluded that biodegradable PU nerve guides result in similar functional recovery when compared with autografts, but their histological quality is significantly better. ACTH4-9 showed only slight, but significant, improved nerve growth promoting activity. Therefore biodegradable PU nerve guides with ACTH4-9 would appear to be promising alternatives to autografts for bridging nerve defects.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Robinson PH,van der Lei B,Hoppen HJ,Leenslag JW,Pennings AJ,Nieuwenhuis P

doi

10.1002/micr.1920120608

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

412-9

issue

6

eissn

0738-1085

issn

1098-2752

journal_volume

12

pub_type

杂志文章
  • Repair of a large pharyngocutaneous fistula with a free jejunal patch flap after salvage laryngectomy: A case report.

    abstract::Preoperative chemoradiation therapy increases the risk of pharyngocutaneous fistula (PCF) after laryngectomy. In this report, we describe the use of a free jejunal patch flap and a deltopectoral flap for surgical treatment of a large PCF. A 52-year-old man underwent salvage laryngectomy and right neck dissection after...

    journal_title:Microsurgery

    pub_type:

    doi:10.1002/micr.22464

    authors: Hirano T,Iwasaki T,Fujita K,Takeno S,Suzuki M

    更新日期:2017-01-01 00:00:00

  • Cross-leg tibial posterior perforator flap.

    abstract:BACKGROUND:In the lower leg posttraumatic pathology, we are frequently confronted with tissue defects that are difficult to cover by local or distance means, because of either the poor tissue quality or the precarious local vessels. One of the still available methods for solving these cases remains the cross-leg flap. ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20375

    authors: Georgescu AV,Irina C,Ileana M

    更新日期:2007-01-01 00:00:00

  • Multifactorial effects on the patency rates of forearm arterial repairs.

    abstract::It is clear that the late clinical symptomatology and the patency of forearm arterial repairs have been contradictory. This study, during which the relationship between the symptomatology and patency has been studied, explores the influence of the local hemodynamic changes and the effect of microsurgical technique on ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1006

    authors: Bacakoğlu A,Ozkan MH,Coşkunol E,Ozdemir O,Ekin A

    更新日期:2001-01-01 00:00:00

  • Cotransplanted hepatic stellate cells enhance vascularization of islet allografts.

    abstract::Islet transplantation is an alternative to whole pancreas transplantation in curative therapy of diabetics. The outcome of engraftment of islet, however, remains disappointing. Rapid and adequate islet revascularization is crucial for the survival and function of transplanted islets. In this study, hepatic stellate ce...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20365

    authors: Yin Z,Wu W,Fung JJ,Lu L,Qian S

    更新日期:2007-01-01 00:00:00

  • Evaluation of 389 patients following free-flap lower extremity reconstruction with respect to secondary refinement procedures.

    abstract:INTRODUCTION:Primary functional and aesthetic results after free-flap salvage of lower extremities are occasionally suboptimal. The objective of this study was to identify predictors for secondary refinement procedures such as liposuction, dermolipectomy, or direct excision. In addition, patient-reported long-term sati...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30219

    authors: Kotsougiani D,Platte J,Bigdeli AK,Hoener B,Kremer T,Kneser U,Harhaus L

    更新日期:2018-03-01 00:00:00

  • Prevention and treatment of painful neuromas of the superficial radial nerve by the end-to-side nerve repair concept: an experimental study and preliminary clinical experience.

    abstract::This article studies the utilization of the end-to-side neurorrhaphy concept in the prevention and treatment of painful neuromas. A total of 20 rats were divided into 2 groups (10 rats per group). In group A, the tibial nerve was divided and left lying in the subcutaneous tissue. In group B, the cut ends of the tibial...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2752(2000)20:3<99::aid-micr1>3.

    authors: Al-Qattan MM

    更新日期:2000-01-01 00:00:00

  • Nerve repair by means of vein filled with muscle grafts. II. Morphological analysis of regeneration.

    abstract::The morphological features of regeneration in long-distance (3 cm) muscle-vein-combined grafts were experimentally investigated in the rat sciatic nerve by means of light and electron microscopy. In the early phases of regeneration (14 days after surgery), many regenerating nerve fibers were detected along the muscle-...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2752(2000)20:1<37::aid-micr7>3.

    authors: Battiston B,Tos P,Geuna S,Giacobini-Robecchi MG,Guglielmone R

    更新日期:2000-01-01 00:00:00

  • Preoperative vascular mapping for anterolateral thigh flap surgeries: A clinical trial of photoacoustic tomography imaging.

    abstract:BACKGROUND:Photoacoustic tomography (PAT) is a noninvasive vascular imaging modality that uses near-infrared pulse laser beams and ultrasound (US) to visualize vessels. We previously demonstrated the utility of PAT for visualizing anterolateral thigh (ALT) perforators in a clinical study of 10 thighs in 5 healthy adult...

    journal_title:Microsurgery

    pub_type: 临床试验,杂志文章

    doi:10.1002/micr.30531

    authors: Tsuge I,Saito S,Yamamoto G,Sekiguchi H,Yoshikawa A,Matsumoto Y,Suzuki S,Toi M

    更新日期:2020-03-01 00:00:00

  • Medial approach to the peroneal vessels as recipients for free flap reconstruction of the leg.

    abstract::The anatomic variation in the branching pattern of the popliteal vessel has been well-established. Little has been written in the literature regarding recipient vessel selection for microvascular reconstruction in the lower extremity as it pertains to aberrant vascular anatomy. We present the case of a 57-year-old mal...

    journal_title:Microsurgery

    pub_type:

    doi:10.1002/micr.30462

    authors: Elswick SM,Miglani A,Lettieri SC

    更新日期:2020-02-01 00:00:00

  • Natural course of postsurgical adhesions.

    abstract::To evaluate the natural course of postsurgical adhesion formation, a descriptive animal study was performed in a standardized rat adhesion model, involving the uterine horn and peritoneal side wall. Extent and type of postsurgical adhesion formation was evaluated at increasing postoperative time intervals up to 1 year...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920160912

    authors: Bakkum EA,Trimbos-Kemper TC

    更新日期:1995-01-01 00:00:00

  • Biomechanical assessment of fixation methods for segmental mandible reconstruction with fibula in the polyurethane model.

    abstract:BACKGROUND:A variety of plating techniques are employed by microsurgeons to provide rigid fixation for vascularized bone constructs of the mandible. The aim of this study was to biomechanically compare three commonly utilized plating techniques for rigid fixation of fibula bone flaps in reconstructing lateral segmental...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30052

    authors: Fontana SC,Smith RB,Nazir N,Andrews BT

    更新日期:2016-05-01 00:00:00

  • Microsurgery for treatment of peripheral lymphedema: long-term outcome and future perspectives.

    abstract::Authors report over 30 years of their own clinical experience in the treatment of chronic peripheral lymphedemas by microsurgical techniques performed at the Center of Lymphatic Surgery of the University of Genoa, Italy. Over 1,500 lymphedema patients were treated with microsurgical techniques. Derivative lymphatic-ve...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20346

    authors: Campisi C,Eretta C,Pertile D,Da Rin E,Campisi C,Macciò A,Campisi M,Accogli S,Bellini C,Bonioli E,Boccardo F

    更新日期:2007-01-01 00:00:00

  • Value of a dynamic MR scan in predicting vascular ingrowth from free vascularized scapular transplant used for treatment of avascular femoral head necrosis.

    abstract::We have treated three patients with avascular osteonecrosis using vascularized scapular bone graft. To predict blood perfusion in both the diseased femoral head and the transferred bone, all the hips were followed up using dynamic magnetic resonance (MR) scans, performed 1 and 7 months after surgery. In the present ca...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920161004

    authors: Fujisawa K,Hirata H,Inada H,Morita A,Takeda K,Hibasami H

    更新日期:1995-01-01 00:00:00

  • Survival of microvascular free flaps in mandibular reconstruction: A systematic review and meta-analysis.

    abstract:BACKGROUND:Free tissue transfer is commonly used in the reconstruction of post-ablative defects of the mandible. Due to lack of statistical power, comparing the survival of various free flaps, even in large studies, is challenging. The purpose of this study was to perform a meta-analysis comparing the survival of the m...

    journal_title:Microsurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/micr.22471

    authors: Markiewicz MR,Bell RB,Bui TG,Dierks EJ,Ruiz R,Gelesko S,Pirgousis P,Fernandes R

    更新日期:2015-10-01 00:00:00

  • Re-animation of muscle flaps for improved function in dynamic myoplasty.

    abstract::The authors report on a series of experiments designed to produce a skeletal muscle contraction functional for dynamic myoplasties. Conventional stimulation techniques recruit all or most of the muscle fibers simultaneously and with maximal strength. This approach has limitations in free dynamic muscle flap transfers ...

    journal_title:Microsurgery

    pub_type: 杂志文章,评审

    doi:10.1002/micr.1052

    authors: Stremel RW,Zonnevijlle ED

    更新日期:2001-01-01 00:00:00

  • Application of Kunlin's technique in vascular micro-anastomosis: experimental and clinical study.

    abstract::Vascular microanastomosis of vessels that presents marked discrepancy in size can be performed without difficulty by making a longitudinal incision of the end of the smallest vessel, forming a kind of "spatula," and joined to the vessel of greater diameter. ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920060111

    authors: Fossati E,Asurey N,Irigaray A

    更新日期:1985-01-01 00:00:00

  • Reliable transfer of multiple perforator-based pedicled flaps: Surgical technique and clinical outcomes.

    abstract:PURPOSE:Although an increase in flap perfusion by incorporating multiple perforators has been demonstrated with free perforator flaps, whether the same efficacy can be achieved with pedicled flaps remains unclear, due to concerns regarding pedicle tension or kinking during flap transposition. The aim of this report was...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22427

    authors: Kwon JH,Lee KT,Lim SY,Pyon JK,Bang SI,Oh KS,Mun GH

    更新日期:2017-02-01 00:00:00

  • Natural history of digital replantation: a 12-year prospective study.

    abstract:UNLABELLED:The purpose of the study was to evaluate the fate of the digital arterial anastomoses, resting total digit blood flow, and cold-induced discomfort following digital replantation with two repaired arteries. The evaluation was done with a Doppler ultrasound of the anastomoses, temperature recording from the fi...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920160304

    authors: Povlsen B,Nylander G,Nylander E

    更新日期:1995-01-01 00:00:00

  • Canine experimental free muscle transplantation.

    abstract::Transplants of the cranial portion of the dog sartorius muscle were able to generate 70% of control force after 3 months if the artery, vein, and nerve were reanastomosed. Our histological and histochemical findings correlate with the functional findings. In a separate group of animals that had their muscles denervate...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920070302

    authors: Stevanovic MV,Seaber AV,Urbaniak JR

    更新日期:1986-01-01 00:00:00

  • Proximal nerve elongation vs nerve grafting in repairing segmental nerve defects in rabbits.

    abstract::If segmental nerve defects could be repaired by elongating the proximal or distal segments, nerve grafting might be unnecessary. We elongated a 40-mm proximal segment of an injured median nerve, in the rabbit right forelimb, at a rate of 1 mm/day for 10 days in 10 rabbits and for 15 days in another 10. On the left for...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20039

    authors: Baoguo J,Shibata M,Matsuzaki H,Takahashi HE

    更新日期:2004-01-01 00:00:00

  • Free versus perforator-pedicled propeller flaps in lower extremity reconstruction: What is the safest coverage? A meta-analysis.

    abstract:INTRODUCTION:Currently, increasingly reconstructive surgeon consider the failure rates of perforator propeller flaps especially in the distal third of the lower leg are too important and prefer to return to the use of free flap at first line option with failure rates frequently lower than 5%. So, we performed a systema...

    journal_title:Microsurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/micr.30047

    authors: Bekara F,Herlin C,Somda S,de Runz A,Grolleau JL,Chaput B

    更新日期:2018-01-01 00:00:00

  • Microsurgical application of freeze-dried venous allografts.

    abstract::Freeze-dried venous interposition allografts with an internal diameter of 1.0 mm and a length of 1.0 cm were placed into the femoral arteries of 17 Sprague-Dawley albino male rats in order to investigate patency and host tissue response. The immediate patency rate was 88%. The epigastric island flap was monitored as a...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920060405

    authors: Pratt MF,Schneider J,Norris MS

    更新日期:1985-01-01 00:00:00

  • Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

    abstract::The purpose of this study was to evaluate the effect of wrapping bioabsorbable nerve conduit around primary suture repair on motor nerve regeneration in a rat model. Forty rats were randomly divided into two experimental groups according to the type of repair of the rat sciatic nerve: group I had primary suture repair...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22274

    authors: Lee JY,Parisi TJ,Friedrich PF,Bishop AT,Shin AY

    更新日期:2014-10-01 00:00:00

  • Abdominoplasty as the patient impetus for selection of the deep inferior epigastric artery perforator free flap for knee coverage.

    abstract::Extensive wounds about the knee can rarely be covered with local or even regional flaps. Free flaps often then become obligatory. Many factors will determine the surgeon's selection of the best donor site. Yet the patients' concerns with donor site morbidity cannot be overlooked. Most would agree that a large, but rel...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22144

    authors: Hallock GG

    更新日期:2014-02-01 00:00:00

  • The effect of supporting a surgeon's wrist on their hand tremor.

    abstract:BACKGROUND:Operative tremor can greatly influence the outcome of certain, precise, microsurgical operations. Reducing a surgeons tremor may not only improve the operative results but decrease the operative time. Previous studies have only measured uni or bi directional tremor and therefore have been unable to calculate...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20776

    authors: Coulson CJ,Slack PS,Ma X

    更新日期:2010-10-01 00:00:00

  • Quantity of lymph nodes correlates with improvement in lymphatic drainage in treatment of hind limb lymphedema with lymph node flap transfer in rats.

    abstract:PURPOSE:This study was conducted to investigate the correlation between the number of vascularized lymph nodes (LN) transferred and resolution of hind limb lymphedema in a rat model. METHODS:Unilateral hind limb lymphedema was created in 18 male Sprague-Dawley rats following inguinal and popliteal LN resection and rad...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22388

    authors: Nguyen DH,Chou PY,Hsieh YH,Momeni A,Fang YH,Patel KM,Yang CY,Cheng MH

    更新日期:2016-03-01 00:00:00

  • A pedicled muscle flap based solely on a neural pedicle.

    abstract::We tested the hypothesis that the intrinsic vascular plexus of the motor nerve could support viability in a rat hindlimb muscle flap. In a preliminary study, we examined the course and vascularity of the sciatic nerve, the peroneal nerve, and the peroneous longus muscle in the rat hindlimb via anatomic dissection, mic...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20609

    authors: Avci G,Akan M,Akoz T,Kuzon W,Gul AE

    更新日期:2009-01-01 00:00:00

  • Recovery of touch after median nerve lesion and subsequent repair.

    abstract::Many techniques have been developed for the evaluation of peripheral nerve function. Consequently, physicians use different techniques in the clinic. This study describes the evaluation of touch after median nerve lesions in the forearm and repair. In order to evaluate touch, 25 patients, aged 11-51 years (mean, 29 ye...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.10087

    authors: Meek MF,Coert JH,Wong KH

    更新日期:2003-01-01 00:00:00

  • Evaluation of the effect of pharmacologic agents on crush-avulsion arterial injuries: a scanning electron microscopy study.

    abstract::This study was designed to investigate the short-term formation and composition of thrombus occurring at sites of arterial intimal injury in rabbits. Anti-coagulants, platelet anti-aggregation agents, and fibrinolytic agents were evaluated for their influence upon the developing thrombus, utilizing scanning electron m...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920120413

    authors: Savoie FH,Cooley BC,Gould JS

    更新日期:1991-01-01 00:00:00

  • Technique of total hepatectomy in the rat.

    abstract::We report a novel one-stage technique of total hepatectomy in the rat, in which the liver is replaced by an autologous prosthesis. This prosthesis is obtained from a donor rat, and consists of the subhepatic vena cava and the left renal vein harvested en block. This graft is sutured with the subdiaphragmatic cava and ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920160711

    authors: Lorenzo M,Angrisani L,Ventriglia R,Ismail T,Tesauro B

    更新日期:1995-01-01 00:00:00