Cotransplanted hepatic stellate cells enhance vascularization of islet allografts.

Abstract:

:Islet transplantation is an alternative to whole pancreas transplantation in curative therapy of diabetics. The outcome of engraftment of islet, however, remains disappointing. Rapid and adequate islet revascularization is crucial for the survival and function of transplanted islets. In this study, hepatic stellate cells (HSC) were cotransplanted with islet allografts, achieving marked prolongation of islet allografts. This was associated with enhanced revascularization within islet grafts as determined by anti-CD31 antibody staining.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Yin Z,Wu W,Fung JJ,Lu L,Qian S

doi

10.1002/micr.20365

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

324-7

issue

4

eissn

0738-1085

issn

1098-2752

journal_volume

27

pub_type

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