Abstract：
BACKGROUND/AIM:Uric acid was successfully used in both, prevention and treatment of the animal model of multiple sclerosis (MS). Recently it has been shown that inosine, a ribosylated precursor of uric acid, might be used to elevate serum uric acid levels in MS patients. The aim of this study was to evaluate the safety and efficacy of oral inosine as a single drug treatment in patients with MS. METHOD:We administered inosine orally to 32 MS patients from 2001-2004 year at doses from 1-2 g daily (given twice) depending on the pretreatment serum uric acid levels. The mean follow-up interval was 37.69+/-6.55 months. The other 32 MS patients, without any treatment except for a relapse period (matched by age, sex, duration of disease and functional disability), were used as controls. The follow-up interval of these patients was 36.39 +/- 2.68 months. The neurological disability was evaluated by the Expanded Disability Status Scale score (EDSS). RESULTS:During the observed period the treated MS patients were found to have the lower relapses rate than the non-treated MS patients (Chi-square test, p = 0.001). None of the patients have showed any adverse effect of inosine treatment. The non-treated MS patients were found to have a higher increasing in the mean EDSS score than the treated ones (two-way ANOVA-repeated measures/factor times, p = 0.025). CONCLUSION:Our results suggested that the treatment approaches based on the elevation of serum uric acid levels might prove beneficial for some MS patients.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Toncev Gdoi
10.2298/vsp0610879tsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
879-82issue
10eissn
0042-8450issn
2406-0720journal_volume
63pub_type
杂志文章abstract：BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1104321v
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Acquired elevation of the diaphragm is mostly the result of phrenic nerve paralysis, some of thoracic and abdominal patological states, and also some of neuromuscular diseases. Surgical treatment is rarely performed and is indicated when lung compression produces disabilitating dyspnea, and includes plicatio...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0704279c
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1504342s
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND/AIM:Socio-economic changes that occured in the wake of dismemberment of former Yugoslavia resulted in the appearance of social pathology, one of which was the increase in the use of psychoactive substances. The overwhole epidemiological research in the use of psychoactive substances has not been conducted so...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0806441p
更新日期：2008-06-01 00:00:00
abstract：INTRODUCTION:Peripartum cardiomyopathy is a life threatening condition of unknown cause that occurs in previously healthy women. It is characterized by symptoms of heart failure due to left ventricular dysfunction that occurs in the last month of pregnancy or the first five months after delivery. CASE REPORT:We presen...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND/AIM:There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. METHODS:Experimental animals (18...
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pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:Myxomas arising from the right ventricle are extremely rare. CASE REPORT:We presented a 71-year-old patient with worsening symptoms of the exertional dyspnea and atypical chest pains lasting 6 months. A transthoracic and transesophageal echocardiogram revealed a large, 2.6 x 2.2 cm, ovoid, well-circumscri...
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pub_type： 杂志文章
doi：10.2298/vsp1306609o
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND/AIM:[corrected] Increased values of thyroid hormones in the clinical syndrome of hyperthyreosis affect blood pres sure values and its circadial variation. The aim of this study was to define the influence of hyperthyreosis on the values and circadial variations of arterial blood pressure, as well as to inves...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0802135i
更新日期：2008-02-01 00:00:00
abstract：:The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy a...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：Background/Aim:Although chlorpromazine (CPZ) is an antipsychotic drug widely used in clinical practice for a long time, its mechanism of action has not been entirely defined. An extremely difficult managing of patients acutely poisoned with CPZ is additional reason for detailed studying its toxicity mechanisms. In this...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP140423047D
更新日期：2017-04-01 00:00:00
abstract：:Results of nutritional status, physical development and fitness examination in 414 infantrymen from 4 garrisons have been presented. Examinations have been undertaken in two phases: immediately after entering the army and at the end of the military service. Somatometric values and physical fitness results suggest the ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Rituximab selectively targets CD20+ B cells and presumably protects joints in rheumatoid arthritis. Complete remissions after a single treatment with rituximab, in some cases for longer than 1 year, are observed in only the minority of patients. We reported a patient suffering from refractory rheumatoid ar...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1201078g
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND/AIM:Thanatophobia is an exaggerated, specific, structured fear of death. It appears in childhood and continues to grow over the years, and in the old age it is accompanied with nosophobia and other mental disorders. The aim of this study was to analyze thanatophobia in dialysed patients which was in the dire...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0604397n
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND/AIM:Tibial perfusion in diabetic microangiopathy is considered to be a diagnostic problem. A special place in quantifying muscle microcirculatory perfusion belongs to thallium 201 muscle perfusion scintigraphy (201T1 PS). Thallium, showing the characteristics of potassium (K+), enters a cell by means of acti...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1102161c
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:[corrected] Descending necrotizing mediastinitis (DNM) is an acute, serious, septic disease which results from a complication of oropharyngeal infection. The disease requires a prompt diagnosis and radical surgical treatment to reduce high mortality (40%). The optimal form of mediastinal drainage remains con...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0607677c
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4-methylenedioxyamphetamine (MDA), amphetamine, methamphetamine, and ketamine. Aft...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0709635d
更新日期：2007-09-01 00:00:00
abstract：:In retrospective, non-randomized study were analyzed 45 patients with local recurrences of rectal carcinoma treated by combined external beam radiotherapy (EBRT) and "High dose rate (HDR) remote afterloading" brachytherapy in the period from January 1st, 1988 to May 1st, 1988. Depending on the localization of the loca...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:In the treatment of ununited diaphyseal fractures the authors stick to three basic principles: rigid fragment stabilization, reduced fracture split and osteogenous stimulus addition. A multiple autologous spongious iliac bone graft was used as an ostogenous stimulus. This method was applied in 47 patients within the p...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：INTRODUCTION:Sinus histiocytosis with massive lymphadenopathy is a rare benign self-limiting disease of unknown etiology. The salivary gland involvement, indicating the extranodal character of the disease, often presents a diagnostic dilemma requiring immunohistochemical staining of surgically removed tumor to confirm ...
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pub_type： 杂志文章
doi：10.2298/vsp1408780p
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:Metastatic renal cell carcinoma (RCC) frequently spreads not only to neighboring lymph nodes, but also to distant organs, including the lungs, liver, bones and brain. CASE REPORT:We presented three cases of RCC with colon metastasis. In the first, 63-year-old patient, after left nephrectomy followed with ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp120515014m
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND/AIM:Oxidative stress is a state of disturbed balance between reactive oxygen species (ROS) and reactive nitrogen species (RNS) on the one hand, and antioxidative defense on the other. As a result of oxidative stress we have irreversible changes in cell function leading to pathological tissue changes, develop...
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pub_type： 杂志文章
doi：10.2298/vsp0907551p
更新日期：2009-07-01 00:00:00
abstract：:The retrospective analysis was performed of 26 patients (5 women and 21 men), mean age of 47.04 years, surgically treated for aortic dissecting aneurysm (ADA) at the Clinic of Cardiosurgery of the M.M.A. in the period 1988-1990. In the postoperative course acute renal insufficiency (ARI) has developed in 13 (50%) pati...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：INTRODUCTION/AIM:By analysing activity of some of the enzymes normally present in the saliva and the level of malondialdehyde in gingivitis, it is possible to estimate the functional condition of parodontium, and the examined parametres can be considered as biochemical markers of its functional condition. The aim of th...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0911892t
更新日期：2009-11-01 00:00:00
abstract：:The test results of lithium carbonate tablets, made of various binding substances (maize starch, gelatin, sodium carboxymethylcellulose 7pp, kollidon 30) were presented. The content of lithium carbonate, tablets weight variation, hardness, friability, disintegration, as well as the lithium carbonate dissolution rate w...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND/AIM:Congenital absence of vagina is known from ancient times of Greek. According to the literature data, incidence is 1/4 000 to 1/20 000. Treatment of this anomaly includes non-operative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to establish ana...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0902107k
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND/AIM:Ever since the time when the first orthotopic urinary diversion (pouch) was performed there has been a constant improvement and modification of surgical techniques. The aim has been to create a urinary reservoir similar to normal bladder, to decrease incidence of postoperative complications and provide a...
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pub_type： 杂志文章
doi：10.2298/vsp1007558b
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND/AIM:Factors associated with mortality and morbidity following coronary artery bypass graft surgery have been well defined and the Parsonnet score is widely used in mortality prediction. The evaluation of quality of life has not been still implemented in everyday work and preoperative echocardiographic factor...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0909718z
更新日期：2009-09-01 00:00:00
abstract：:Occupational environment risk factors and health status of 172 soldiers and 89 officers were examined aiming to discover early signs of occupational diseases and disorders in artillery personnel. Among all physical and chemical risk factors noise caused by artillery and infantry firing (140 to over 170 dB) were the mo...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND/AIM:The differential diagnosis of fever of unknown origin (FUO) includes more than 200 different diseases and conditions. The aim of this study was to identify the most frequent causes of FUO among adult patients according to gender and age. METHODS:The study included 74 patients examined from June 2010 to ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp140820128p
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To evaluate how infection of extremity after war wound influenced the possibilities and immediate effects of a physical therapy. METHODS:The retrospective clinical investigation comparing two groups: group A (n = 86) with infection, group B (n = 87) without infection. Main indicators for possibilities of the...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
