Abstract:
Background/Aim:Although chlorpromazine (CPZ) is an antipsychotic drug widely used in clinical practice for a long time, its mechanism of action has not been entirely defined. An extremely difficult managing of patients acutely poisoned with CPZ is additional reason for detailed studying its toxicity mechanisms. In this clinical study, we investigated whether the oxidative stress (OS) mediates CPZ toxic effects in the exposed patients. Methods:The patients were organized into 3 groups: the T-group - hospitalized patients receiving therapeutic doses of 75-150 mg CPZ/day; the overdosed group, divided into two subgroups: the group M and the group S - mildly (CPZ serum concentration: 0.21 ± 0.05 mg/L) and severely (CPZ serum concentration: 2.66 ± 0.25 mg/L) poisoned patients, respectively, and the group C (control group of healthy volunteers). Oxidative stress parameters [total antioxidative status (TAS) and malondialdehyde (MDA) in plasma)] and superoxide dismutase (SOD) activity in erythrocytes were measured spectrophotometrically, and CPZ concentrations in serum were monitored chromatographically. One set of measurements was performed in the group C and T, whereas two sets of measurements (after 24 hours and 48 hours) were done in the poisoned patients, groups M and S. Results:A decrease of TAS and increase of SOD activity were obtained in both subgroups of the poisoned patients, compared to the controls and the group receiving therapeutic doses of CPZ. A significant increase of MDA was achieved in severely poisoned patients, compared to all other groups. Conclusion:Changed oxidative stress parameters in patients poisoned with chlorpromazine indicate involvement of oxidative stress in the toxicity mechanism(s) of chlorpromazine.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Dejanović B,Vuković-Dejanović V,Stevanović I,Stojanović I,Mandić Gajić G,Dilber Sdoi
10.2298/VSP140423047Dsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
312-7issue
4eissn
0042-8450issn
2406-0720journal_volume
73pub_type
杂志文章abstract:BACKGROUND/AIM:Myxoma is the most common benign primary cardiac neoplasm, and usually originates from the left atrial septum. Early diagnosis of cardiac myxomas depends on a high index of a clinical suspicion. Surgical management must be done as soon as possible after diagnosis. The aim of this retrospective study was ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1110851r
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND/AIM:The task of a forensic examiner during exhumation of skeletal remains is to calculate antemortem height of a person whose skeletal remains were found. Anthropological investigations which provided formulae for calculating ante-mortem body height date back from XIX or from the first half of XX centuries. ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1205394m
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND/AIM:Thanatophobia is an exaggerated, specific, structured fear of death. It appears in childhood and continues to grow over the years, and in the old age it is accompanied with nosophobia and other mental disorders. The aim of this study was to analyze thanatophobia in dialysed patients which was in the dire...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0604397n
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:Retroperitoneal hematoma may occur as a result of trauma, but also from rapture of arterial aneurysms (aortic or iliac), surgical complications, tumors or anticoagulation therapy. CASE REPORT:We presented a patient on permanent anticoagulation therapy. On the day of admission to our institudon, the patien...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp130924012s
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION/AIM:There are numerous factors that influence the formation of condylar processus: the growth and development of cranial base, growth and development of the jaws and alveolar extensions, teething, the way of intercuspidation, the overlap of incisors, functions of masticatory muscles, etc. Considering the f...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0807513c
更新日期:2008-07-01 00:00:00
abstract::The effect of gamaphos (0.6 mmol kg-1 im, 20 min before irradiation) was investigated upon the course and outcome of the surgical management of combined radiation-gunshot injury in pigs. The hypothesis was tested that the infliction of perforating gunshot injury (LD0/30 days) in pigs in the latent phase of the acute r...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIM:There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. METHODS:Experimental animals (18...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-06-01 00:00:00
abstract::The cross-sectional study comprised 8095 officers of the Y.P.A. from the limited territory, and relationship between cardiovascular risk factors and prevalence of ischemic heart disease (IHD) has been analysed. The high and statistically significant positive relationship of serum cholesterol, blood pressure, relative ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:INTRODUCTION:Dental injuries in immature permanent teeth often result in endodontic complications. Apexification technique using calcium hydroxide is associated with certain flaws, such as long treatment time, the possibility of tooth fracture and incomplete calcification. The use of an apical plug employing mineral tr...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1308781c
更新日期:2013-08-01 00:00:00
abstract::In the period from January 1st, 1969, to December 31st, 1988, 585 osteosyntheses of the closed bone fractures of lower limbs were performed at the Orthopedic department at the Military Hospital in Nis. At the same period 25 postoperative osteomyelitis were registered, i.e., 4.27%. The average duration of osteosynthesi...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND/AIM:Ever since the time when the first orthotopic urinary diversion (pouch) was performed there has been a constant improvement and modification of surgical techniques. The aim has been to create a urinary reservoir similar to normal bladder, to decrease incidence of postoperative complications and provide a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1007558b
更新日期:2010-07-01 00:00:00
abstract::War injuries of colon and rectum are real challenge for war surgeons. The aim of the study was to point out the necessity of war surgical doctrine application, considering the risk factors in the choice of primary surgical procedure and surgeon's experience in managing this kind of injuries. Postoperative complication...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Comparative clinical investigation was performed in 80 ASA I/II patients undergoing cataract surgery on one eye. Patients were randomly divided in to four groups, according to the method of anesthesia. Intraoperatively (T0-T6), decreasing of intraocular pressure (IOP) to the optimal values at the start of the operatio...
journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND/AIM:Unknown cause of infertility exists in 10%-26% of couples with infertility problems. Treatment of these couples depends on the posibility of correcting the unidentified defect over time. Intrauterine insemination (IUI) and ovaluation stimulation are methods of choice in treatment of unexplained fertility...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1204301j
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:Trichobezoars are foreign bodies in gastrointestinal tract, composed of hair. They occur mainly in children and adolescents suffering from trichotillophagia. They commonly occur in the stomach, but as they enlarge over time, they can extend through the pylorus into distal parts of the small intestine resem...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0702155c
更新日期:2007-02-01 00:00:00
abstract::Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided in to groups according to etiology (enterovirus meningitis-ENTERO, serous meningitis various etiology-SM and tuberculous mening...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0203265t
更新日期:2002-05-01 00:00:00
abstract:INTRODUCTION:Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is one of the most common single-gene disorders (mutation on chromosome 17q) and usually associated with cutaneous, musculoskeletal and neurological disorders in humans. NF1 is generally complicated with one or more neurobehavioral d...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp141007146i
更新日期:2016-02-01 00:00:00
abstract::The test results of calcium carbonate tablets, made of different binding substances (microcrystal cellulose, gelatin, 7pp sodium carboxymethylcellulose and starch) were presented. The content of calcium-carbonate in tablets as well as varying, solidity, prodigality and aptness to decay was determined. The best propert...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND/AIM:Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a definite result is available. Molecular methods, especially those bas...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0912992l
更新日期:2009-12-01 00:00:00
abstract::Esophageal stapler transection was performed in 15 patients with bleeding from the dilated esophageal veins in the period 1984-1988. In 7 patients operated on as urgent cases due to prolonged uncontrolled bleeding, the mortality was high--71.4%, contrary to the group of electively operated patients in whom the mortali...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIM:Urinary tract infections are still the most frequent complications in patients with spinal cord injury (SCI). The aim of this study was to analyze the factors influencing development of urinary tract infections during rehabilitation in patients with SCI. METHODS:This retrospective case/control study inc...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140725116s
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:Minimal bone changes in the acetabulum and/or proximal femur, through mechanism known as femoroacetabular impingement, during flexion, adduction and internal rotation lead to early contact between femoral head-neck junction and acetabular brim, in anterosuperior region. Each additional pathological substra...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp131207109m
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:Synchronous gastric and colorectal cancer is present in 4% of cases, commonly as additional finding. This is the case of invasive, synchronous gastric and sigmoid colon cancer. CASE REPORT:A 63-years-old male patient admitted to our institution complaining on pains in epigastrium, vomiting, rapid weight l...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND/AIM:Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a ma...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp131106050d
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND/AIM:Modem ultrasound systems allow high-resolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) and is thought to reflect ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0808601m
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied--directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp0508565t
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1504342s
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND/AIM:Uric acid was successfully used in both, prevention and treatment of the animal model of multiple sclerosis (MS). Recently it has been shown that inosine, a ribosylated precursor of uric acid, might be used to elevate serum uric acid levels in MS patients. The aim of this study was to evaluate the safety...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0610879t
更新日期:2006-10-01 00:00:00