In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter.

abstract：:In prostate cancer, confirmation of metastatic involvement of the skeleton has traditionally been achieved by bone scintigraphy, although the widespread availability of prostate-specific antigen (PSA) measurements has tended to eliminate the need for this investigation. The potential of bone scintigraphy to predict sk...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Soerdjbalie-Maikoe V,Pelger RC,Lycklama à Nijeholt GA,Arndt JW,Zwinderman AH,Bril H,Papapoulos SE,Hamdy NA

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis and have, therefore, been integrated in the World Health Organization (WHO) classification in 2016. The aim of this study was to characterize static and dynamic...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Verger A,Stoffels G,Bauer EK,Lohmann P,Blau T,Fink GR,Neumaier B,Shah NJ,Langen KJ,Galldiks N

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:PET has been proven to be helpful in the delineation of gross tumour volume (GTV) for external radiation therapy in several tumour entities. The aim of this study was to determine if [(11)C]choline PET could be used to localize the carcinomatous tissue within the prostate in order to specifically target this ar...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bundschuh RA,Wendl CM,Weirich G,Eiber M,Souvatzoglou M,Treiber U,Kübler H,Maurer T,Gschwend JE,Geinitz H,Grosu AL,Ziegler SI,Krause BJ

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is commonly accepted as the gold standard to assess outcome after NAC in breast cancer patients. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has unique value in tumor staging, predicting prognosis, and eval...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Li P,Wang X,Xu C,Liu C,Zheng C,Fulham MJ,Feng D,Wang L,Song S,Huang G

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Anti-PD-1/PD-L1 blockade can restore tumour-specific T-cell immunity and is an emerging therapy in non-small-cell lung cancer (NSCLC). We investigated the correlation between 18F-FDG PET/CT-based markers and tumour tissue expression of PD-L1, necrosis and clinical outcome in patients receiving checkpoint inhibi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jreige M,Letovanec I,Chaba K,Renaud S,Rusakiewicz S,Cristina V,Peters S,Krueger T,de Leval L,Kandalaft LE,Nicod-Lalonde M,Romero P,Prior JO,Coukos G,Schaefer N

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. METHODS:Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Acampa W,Caprio MG,Nicolai E,Liuzzi R,De Luca S,Capasso E,Luongo L,Petretta M,Cuocolo A

更新日期：2010-02-01 00:00:00

abstract：:This proposal for standardization of (123)I-metaiodobenzylguanidine (iobenguane, MIBG) cardiac sympathetic imaging includes recommendations for patient information and preparation, radiopharmaceutical, injected activities and dosimetry, image acquisition, quality control, reconstruction methods, attenuation, scatter a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Flotats A,Carrió I,Agostini D,Le Guludec D,Marcassa C,Schäfers M,Somsen GA,Unlu M,Verberne HJ,EANM Cardiovascular Committee.,European Council of Nuclear Cardiology.

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To assess diagnostic accuracy of (18)F-FDG PET/CT at 3 months for the detection of local recurrence after radiofrequency ablation (RFA) of lung metastases. METHODS:The PET/CT scan at 3 months was compared with a baseline PET/CT scan from a maximum of 2 months before RFA, with the reference standard as recurren...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bonichon F,Palussière J,Godbert Y,Pulido M,Descat E,Devillers A,Meunier C,Leboulleux S,de Baère T,Galy-Lacour C,Lagoarde-Segot L,Cazeau AL

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Poor liver tumor visibility after microwave ablation (MWA) limits direct tumor ablation margin assessments using contrast-enhanced CT or ultrasound (US). Positron emission tomography (PET) or PET/CT may offer improved intraprocedural assessment of liver tumor ablation margins versus current imaging techniques, ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yan Z,Khorasani R,Levesque VM,Gerbaudo VH,Shyn PB

更新日期：2020-11-11 00:00:00

abstract：PURPOSE:To evaluate the predictive value of early and late residual (18)F-fluorodeoxyglucose (FDG) and (18)F-fluorothymidine (FLT) uptake using different SUV measurements in PET in patients with advanced non-small-cell lung cancer (NSCLC) treated with erlotinib. METHODS:We retrospectively reviewed data from 30 patient...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kobe C,Scheffler M,Holstein A,Zander T,Nogova L,Lammertsma AA,Boellaard R,Neumaier B,Ullrich RT,Dietlein M,Wolf J,Kahraman D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:This study focusses on a promising carrier system for therapeutic and imaging purposes using meso-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T(3,4)CPP). To assess its potential for clinical use, we labelled T(3,4)CPP with (188)Re and analysed some kinetic biodistribution parameters after intravenou...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jia ZY,Deng HF,Pu MF,Luo SZ

更新日期：2008-04-01 00:00:00

abstract：:When projection data are incomplete for various technical reasons, artefacts may occur in the reconstructed images. This study examines whether an iterative reconstruction method, the ordered subsets implementation of the EM algorithm (OSEM), can improve reconstruction and minimise the artefacts compared to filtered b...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hatton RL,Hutton BF,Angelides S,Choong KK,Larcos G

更新日期：2004-06-01 00:00:00

abstract：AIMS:Perivascular fat attenuation index (FAI) has emerged as a novel coronary computed tomography angiography (CCTA)-based biomarker predicting cardiovascular outcomes by capturing early coronary inflammation. It is currently unknown whether FAI adds prognostic value beyond that provided by single-photon emission compu...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bengs S,Haider A,Warnock GI,Fiechter M,Pargaetzi Y,Rampidis G,Etter D,Wijnen WJ,Portmann A,Osto E,Treyer V,Benz DC,Meisel A,Fuchs TA,Gräni C,Buechel RR,Kaufmann PA,Pazhenkottil AP,Gebhard C

更新日期：2020-11-16 00:00:00

abstract：PURPOSE:[(18)F]FPEB is a promising PET radioligand for the metabotropic glutamate receptor 5 (mGluR5), a potential target for the treatment of neuropsychiatric diseases. The purpose of this study was to evaluate the test-retest reproducibility of [(18)F]FPEB in the human brain. METHODS:Seven healthy male subjects were...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Park E,Sullivan JM,Planeta B,Gallezot JD,Lim K,Lin SF,Ropchan J,McCarthy TJ,Ding YS,Morris ED,Williams WA,Huang Y,Carson RE

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm. METHODS:Two independent dementia experts provided etiological diagnosis ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ramusino MC,Garibotto V,Bacchin R,Altomare D,Dodich A,Assal F,Mendes A,Costa A,Tinazzi M,Morbelli SD,Bauckneht M,Picco A,Dottorini ME,Tranfaglia C,Farotti L,Salvadori N,Moretti D,Savelli G,Tarallo A,Nobili F,Parap

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:The quantitative imaging features (radiomics) that can be obtained from the different modalities of current-generation hybrid imaging can give complementary information with regard to the tumour environment, as they measure different morphologic and functional imaging properties. These multi-parametric ima...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Castiglioni I,Gallivanone F,Soda P,Avanzo M,Stancanello J,Aiello M,Interlenghi M,Salvatore M

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine the incremental staging information provided by positron emission tomography/computed tomography (PET/CT) and its impact on management plans in patients with untreated stage III-IV head and neck squamous cell carcinoma (HNSCC). METHODS:We prospectively studied, betw...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Cacicedo J,Fernandez I,Del Hoyo O,Dolado A,Gómez-Suarez J,Hortelano E,Sancho A,Pijoan JI,Alvarez J,Espinosa JM,Gaafar A,Bilbao P

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T0) to post-onset conditions at 1 month (T1), 1-2 years (T2, T3). METHODS:Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sestini S,Pestelli F,Leoncini M,Bellandi F,Mazzeo C,Mansi L,Carrio I,Castagnoli A

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to analyse the impact of FDG-PET staging on treatment results of neo-adjuvant radiochemotherapy in patients with advanced non-small cell lung cancer (NSCLC). We compared prospectively the outcome of two patient groups with stage III NSCLC undergoing the same neo-adjuvant radio-chemothe...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Eschmann SM,Friedel G,Paulsen F,Reimold M,Hehr T,Scheiderbauer J,Budach W,Kotzerke J,Bares R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to monitor the metabolic effects of temozolomide (TMZ) chemotherapy in malignant gliomas by means of repeated positron emission tomography (PET) with [(11)C]methionine (MET). METHODS:Fifteen patients with histologically proven malignant glioma were treated by TMZ chemotherapy. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Galldiks N,Kracht LW,Burghaus L,Thomas A,Jacobs AH,Heiss WD,Herholz K

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:We present our first clinical experience with O-(2-18F-fluoroethyl)-L-tyrosine (FET) PET in patients with high-grade glioma treated with various neurooncological therapies including tumour-treating fields (TTFields) for the differentiation of tumour progression from treatment-related changes. METHODS:We retros...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ceccon G,Lazaridis L,Stoffels G,Rapp M,Weber M,Blau T,Lohmann P,Kebir S,Herrmann K,Fink GR,Langen KJ,Glas M,Galldiks N

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Standardized uptake value ratio (SUVr) used to quantify amyloid-β burden from amyloid-PET scans can be biased by variations in the tracer's nonspecific (NS) binding caused by the presence of cerebrovascular disease (CeVD). In this work, we propose a novel amyloid-PET quantification approach that harnesses the i...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Liu H,Nai YH,Saridin F,Tanaka T,O' Doherty J,Hilal S,Gyanwali B,Chen CP,Robins EG,Reilhac A

更新日期：2021-01-07 00:00:00

abstract：PURPOSE:(11)C-methionine (MET) PET is an established diagnostic tool for glioma. Studies have suggested that MET uptake intensity in the tumor is a useful index for predicting patient outcome. Because MET uptake is known to reflect tumor expansion more accurately than MRI, we aimed to elucidate the association between ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kobayashi K,Hirata K,Yamaguchi S,Manabe O,Terasaka S,Kobayashi H,Shiga T,Hattori N,Tanaka S,Kuge Y,Tamaki N

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Investigate whether 18F-FDG PET-CT has the potential to predict the major pathologic response (MPR) to neoadjuvant sintilimab in resectable NSCLC patients, and the potential of sifting patients who probably benefit from immunotherapy. METHODS:Treatment-naive patients with resectable NSCLC (stage IA-IIIB) recei...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tao X,Li N,Wu N,He J,Ying J,Gao S,Wang S,Wang J,Wang Z,Ling Y,Tang W,Zhang Z

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The aims were to determine if the maximum standardized uptake value (SUV(max)) of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) is an independent predictor of overall survival and to assess its prognostic value after stratification acc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Agarwal M,Brahmanday G,Bajaj SK,Ravikrishnan KP,Wong CY

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Although resynchronisation therapy (CRT) is a promising addition to heart failure therapy, a substantial number of patients do not respond to CRT. As FDG PET has routinely been used for prediction of improvement after revascularisation in ischaemic cardiomyopathy, it was hypothesised that there is also a relati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Campen CM,Visser FC,van der Weerdt AP,Knaapen P,Comans EF,Lammertsma AA,de Cock CC,Visser CA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the impact of [18F]fluorodeoxy-D-glucose positron emission tomography (FDG-PET) on the primary staging of patients with small-cell lung cancer (SCLC). METHODS:FDG-PET was performed in 120 consecutive patients with SCLC during primary staging. In addition, brain examina...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brink I,Schumacher T,Mix M,Ruhland S,Stoelben E,Digel W,Henke M,Ghanem N,Moser E,Nitzsche EU

更新日期：2004-12-01 00:00:00

abstract：:Flow quantitation with nitrogen-13 ammonia ((13)NH(3)) and positron emission tomography (PET) is dependent on an accurate blood time-activity curve. This is conveniently derived from the PET images by drawing a region of interest in the left ventricular cavity. The blood time-activity curve obtained in this way, howev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hove JD,Iida H,Kofoed KF,Freiberg J,Holm S,Kelbaek H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The clinical problem in suspected aortoiliac graft infection (AGI) is to obtain proof of infection. Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography scanning (PET) has been suggested to play a pivotal role, an evidence-based interpretation is lacking. The objective of this retrospective...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Saleem BR,Beukinga RJ,Boellaard R,Glaudemans AW,Reijnen MM,Zeebregts CJ,Slart RH

更新日期：2017-05-01 00:00:00

abstract：:The development of monofunctional DTPA derivatives has been a major breakthrough in the labelling of proteins or peptides with a variety of radiometals. Although this methodology is simple and useful for indium-111 labelling, the stability of these conjugates is too low for most therapeutic nuclides. Cyclic chelators,...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Béhé M,Becker W,Gotthardt M,Angerstein C,Behr TM

更新日期：2003-08-01 00:00:00