Abstract：
:The altered gene expression seen in cancer could relate to differences in nonhistone chromatin proteins between normal and malignant tumor cells. Phenol-soluble nonhistone chromatin proteins were isolated from human normal and leukemic (chronic lymphocytic leukemia) B-cells, as well as long-term cultured human B-lymphocyte cell lines. High-resolution two-dimensional electrophoretic maps identified a group of three nuclear proteins with a molecular weight of 45,000 to 50,000 and an isoelectric range of 4.5 to 4.7, which were associated only with the human leukemic B-cells. Leukemic B-cells and cultured B-cell lines also expressed a variant form of nuclear actin and tubulin.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Jones CA,Hesse L,Muzik H,Jerry LMsubject
Has Abstractpub_date
1984-05-01 00:00:00pages
2068-77issue
5eissn
0008-5472issn
1538-7445journal_volume
44pub_type
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