Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest.

abstract：:Obesity is associated with a state of chronic, low-grade inflammation. It is considered that the paracrine loop involving free fatty acid (FFA) and tumor necrosis factor (TNF)α between adipocytes and macrophages establishes an inflammatory vicious cycle that augments the inflammatory changes and insulin resistance in ...

journal_title：Journal of cellular biochemistry

authors： Jiang B,Qiao J,Yang Y,Lu Y

更新日期：2012-08-01 00:00:00

abstract：:Prostate cancer is the commonest non-skin cancer in men. Incidence and mortality rates of this tumor vary strikingly throughout the world. Although several factors have been implicated to explain this remarkable variation, lifestyle and dietary factors may play a dominant role, with sex hormones behaving as intermedia...

journal_title：Journal of cellular biochemistry

authors： Carruba G

更新日期：2007-11-01 00:00:00

abstract：:Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb) are phosphorylated to trigger activation of downstream signaling pathways. To address th...

journal_title：Journal of cellular biochemistry

authors： McCabe IC,Fedorko A,Myers MG Jr,Leinninger G,Scheller E,McCabe LR

更新日期：2019-03-01 00:00:00

abstract：:Isoflavones widely distributed in plants prevent diabetes. This study investigated the in vivo and in vitro effect of 3',4'-dihydroxy-6″,6″,6″',6″'-tetramethylbis(pyrano[2″,3″:5,6::2″',3″':7,8]isoflavone (bis-pyrano prenyl isoflavone) on glucose homeostasis in hyperglycemic rats. The ethyl acetate fraction from aerial...

journal_title：Journal of cellular biochemistry

authors： Altenhofen D,da Luz G,Frederico MJ,Venzke D,Brich M,Vigil S,Fröde TS,Linares CE,Pizzolatti MG,Silva FR

更新日期：2017-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients ...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Zhao XX,Hu XJ,Yang F,Lin P,Cui SC,Zhao W,Cao XY,Wang YS

更新日期：2019-03-01 00:00:00

abstract：:Despite its recognition as the most prevalent HIV associated cancer, speculation still abounds regarding the pathogenesis of AIDS-related Kaposi's sarcoma (AIDS-KS). However, it has been established that both cytokines, e.g. IL-6, and HIV-associated products, e.g., Tat, are integral in AIDS-KS cellular proliferation. ...

journal_title：Journal of cellular biochemistry

authors： Mallery SR,Bailer RT,Hohl CM,Ng-Bautista CL,Ness GM,Livingston BE,Hout BL,Stephens RE,Brierley GP

更新日期：1995-11-01 00:00:00

abstract：:Cellular differentiation is caused by highly controlled modifications in the gene expression but rarely involves a change in the DNA sequence itself. Histone acetylation is a major epigenetic factor that adds an acetyl group to histone proteins, thus altering their interaction with DNA and nuclear proteins. Illuminati...

journal_title：Journal of cellular biochemistry

authors： Tao H,Li Q,Lin Y,Zuo H,Cui Y,Chen S,Chen Z,Liu H

更新日期：2020-03-01 00:00:00

abstract：:It has been proposed carbon tetrachloride (CCl4 ) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous ...

journal_title：Journal of cellular biochemistry

authors： Yousefi-Manesh H,Shirooie S,Partoazar A,Nikoui V,Estakhri MRA,Bakhtiarian A

更新日期：2019-02-15 00:00:00

abstract：:The pathogenesis of hyperprolactinemia (hyperPRL) induced hypogonadism has been suggested to be related with a dysfunction of hypothalamus-pituitary-testis axis. While the direct inhibitory effects of prolactin (PRL) on testosterone (T) release have been demonstrated, the mechanism is still unclear. Our previous study...

journal_title：Journal of cellular biochemistry

authors： Huang WJ,Yeh JY,Kan SF,Chang LS,Wang PS

更新日期：2001-01-01 00:00:00

abstract：:Paxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors. Integrin-mediated binding through the focal adhesion complex is important in metastatic adhesion and is upreg...

journal_title：Journal of cellular biochemistry

authors： Conway WC,Van der Voort van Zyp J,Thamilselvan V,Walsh MF,Crowe DL,Basson MD

更新日期：2006-08-15 00:00:00

abstract：:The regulatory role of regucalcin on cell responses for tumor necrosis factor-alpha (TNF-alpha) or transforming growth factor-beta1 (TGF-beta1) was investigated using the cloned normal rat kidney proximal tubular epithelial NRK52E cells overexpressing regucalcin. NRK52E cells (wild type) and stable regucalcin (RC)/pCX...

journal_title：Journal of cellular biochemistry

authors： Nakagawa T,Yamaguchi M

更新日期：2007-04-01 00:00:00

abstract：:Pre-adipocyte 3T3-L1 cells, after an appropriate induction stimulus, proceed through a defined change in morphology as differentiation progresses. Transforming growth factor beta 1 (TGF beta 1) is able to block the morphological and biochemical changes which occur with differentiation of these cells if given within 36...

journal_title：Journal of cellular biochemistry

authors： Bortell R,Owen TA,Ignotz R,Stein GS,Stein JL

更新日期：1994-02-01 00:00:00

abstract：:Understanding how the information is conveyed from outside to inside the cell is a critical challenge for all biologists involved in signal transduction. The flow of information initiated by cell-cell and cell-extracellular matrix contacts is mediated by the formation of adhesion complexes involving multiple proteins....

journal_title：Journal of cellular biochemistry

authors： Lelièvre SA,Bissell MJ

更新日期：1998-01-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:Four detergents have been compared for identification of the Plasmodium knowlesi variant antigen on infected erythrocytes by immunoprecipitation analysis. Erythrocytes infected with late trophozoite and schizont forms of cloned asexual parasites were labeled by lactoperoxidase-catalyzed radioiodination and extracted e...

journal_title：Journal of cellular biochemistry

authors： Howard RJ,Barnwell JW

更新日期：1984-01-01 00:00:00

abstract：:The Wnt signaling pathway has recently been demonstrated to play an important role in bone cell function. In previous studies using DNA microarray analyses, we observed a change in some of the molecular components of the canonical Wnt pathway namely, frizzled-1 (FZD-1) and axil, in response to continuous parathyroid h...

journal_title：Journal of cellular biochemistry

authors： Kulkarni NH,Halladay DL,Miles RR,Gilbert LM,Frolik CA,Galvin RJ,Martin TJ,Gillespie MT,Onyia JE

更新日期：2005-08-15 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associated with a more aggressive phenot...

journal_title：Journal of cellular biochemistry

authors： Wilson MA,Chrysogelos SA

更新日期：2002-01-01 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of cell function and differentiation. We examined NR expression during osteogenic versus adipogenic differentiation of primary mouse calvarial osteoblasts (MOBs). MOBs were cultured for 21 days in osteogenic or adipogenic differentiation media. von Kossa and Oil Red O stainin...

journal_title：Journal of cellular biochemistry

authors： Pirih FQ,Abayahoudian R,Elashoff D,Parhami F,Nervina JM,Tetradis S

更新日期：2008-12-01 00:00:00

abstract：:Colorectal cancer (CRC), regardless of standard procedures of treatment and screening, is still considered one of the deadliest cancers in the Western world, and in economically developed Asian countries, especially Iran. The current study was undertaken to investigate whether changes in the level of Cripto-1 (CR-1) e...

journal_title：Journal of cellular biochemistry

authors： Igder S,Mohammadiasl J,Azadpour S,Mansouri E,Ashktorab H,Mokarram P

更新日期：2020-04-01 00:00:00

abstract：:The above article, published online on April 18, 2011 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the sec...

journal_title：Journal of cellular biochemistry

authors：

更新日期：2016-08-01 00:00:00

abstract：:Strikingly increased expression of notch-1 has been demonstrated in several human malignancies and pre-neoplastic lesions. However, the functional consequences of notch-1 overexpression in transformed cells remain unclear. We investigated whether endogenously expressed notch-1 controls cell fate determination in mouse...

journal_title：Journal of cellular biochemistry

authors： Shelly LL,Fuchs C,Miele L

更新日期：1999-05-01 00:00:00

abstract：:The physiologically active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has influence over osteoclastogenesis and myelopoiesis, but the regulational mechanism is not well-defined. In this report, formation of osteoclast-like (OCL) cells from primitive myeloid colony-forming cells (PM-CFC) as mediated by ...

journal_title：Journal of cellular biochemistry

authors： Qi DY,Perkins SL,Kling SJ,Russell RG

更新日期：1999-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common type of cancer. MicroRNAs have been reported to participate in the progression of various cancers. In previous studies, miR-301a-3p expression was shown to be upregulated in CRC tissues. However, the underlying mechanism of miR-301a-3p in CRC has not yet been elucidated...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Zhang Y,Zhu H,Sun X,Wang X,Wu P,Xu X

更新日期：2019-04-01 00:00:00

abstract：:The T-box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the development of the atrioventricular channel, the outflow tract and valves, suggesting its potential causative role for the development of Tetralogy of Fallot (TOF...

journal_title：Journal of cellular biochemistry

authors： Hammer S,Toenjes M,Lange M,Fischer JJ,Dunkel I,Mebus S,Grimm CH,Hetzer R,Berger F,Sperling S

更新日期：2008-06-01 00:00:00

abstract：:The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of ...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Zaidi SK,Stein JL,Lian JB,van Wijnen AJ,Montecino M,Young DW,Javed A,Pratap J,Choi JY,Ali SA,Pande S,Hassan MQ

更新日期：2008-08-15 00:00:00

abstract：:Astrocytes, the major glial population in the central nervous system (CNS), can secrete thrombospondin (TSP)-1 that plays the role in synaptogenesis and axonal sprouting during CNS development and tissue repair. However, little is known about the regulation of TSP-1 expression in astrocytes under oxidative stress cond...

journal_title：Journal of cellular biochemistry

authors： Chen JK,Zhan YJ,Yang CS,Tzeng SF

更新日期：2011-01-01 00:00:00

abstract：:Extracellular matrix (ECM) accumulation plays a key role in the progression of bladder outlet obstruction (BOO). Muscarinic receptors have been widely reported to serve as pivotal regulators in lung tissue remodeling. However, the influence of them on human bladder smooth muscle cells (HBSMCs) and the underlying molec...

journal_title：Journal of cellular biochemistry

authors： Chen S,Liao B,Jin X,Wei T,He Q,Lin Y,Ai J,Gong L,Li H,Wang K

更新日期：2020-11-01 00:00:00

abstract：:A panel of monoclonal antibodies and conventional antisera directed against desmosomal proteins from bovine muzzle epidermis was used to identify immunologically related proteins from two other bovine stratified squamous epithelia, cornea and esophagus. Desmosome-enriched tissue fractions were prepared from epidermis,...

journal_title：Journal of cellular biochemistry

authors： Giudice GJ,Cohen SM,Patel NH,Steinberg MS

更新日期：1984-01-01 00:00:00

abstract：:Extracellular nucleotides and nucleosides have emerged as important elements regulating tissue homeostasis. Acting through specific receptors, have the ability to control gene expression patterns to direct cellular fate. We observed that SKOV-3 cells express the ectonucleotidases: ectonucleotide pyrophosphatase 1 (ENP...

journal_title：Journal of cellular biochemistry

authors： Martínez-Ramírez AS,Díaz-Muñoz M,Battastini AM,Campos-Contreras A,Olvera A,Bergamin L,Glaser T,Jacintho Moritz CE,Ulrich H,Vázquez-Cuevas FG

更新日期：2017-12-01 00:00:00