Differential stimulation of synaptosomal norepinephrine uptake by high salt diet in Dahl rats.

Abstract:

:We have studied the norepinephrine (NE) uptake processes directly in synaptosomes isolated from the hypothalamus of both Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats. Both DS and DR rats were divided into two dietary groups, one high salt diet group and one low salt diet group. NE uptake was highly sodium dependent (averaging 80%) and ouabain sensitive (averaging 55%). The initial 3H-NE uptake by the hypothalamic synaptosomal fraction of DR and DS rats on a low salt diet during the first 10-min incubation period averaged 1.19 +/- 0.083 and 1.50 +/- 0.138 pmol/mg protein respectively while those of DR and DS on a high salt diet were 1.69 +/- 0.124 and 1.64 +/- 0.092 pmol/mg protein respectively. Baseline values of NE uptake on low salt diet were relatively high in DS compared to that in DR controls. High salt diet had a stimulatory effect on the net uptake of 3H-NE by hypothalamic synaptosomes of both strains of rats, DS showed an overall enhancement of 9% as compared to DR (42% increase, P = 0.003). This differential enhancement by the high salt diet was apparently contributed to by the sodium-mediated and ouabain sensitive amine uptake process and possibly resulted from a defective inducibility of (Na+-K+)-ATPase in DS rats.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Rho JH,Hough K

doi

10.1097/00004872-198410000-00003

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

461-5

issue

5

eissn

0263-6352

issn

1473-5598

journal_volume

2

pub_type

杂志文章
  • Does home blood pressure allow for a better assessment of the white-coat effect than ambulatory blood pressure?

    abstract:BACKGROUND:The difference between clinic and ambulatory blood pressure (BP) is a poor estimate of the true white-coat effect (WCE) measured with beat-to-beat recording. METHOD:We investigated whether the difference between clinic and home BP (home WCE) was a better estimate of true WCE than ambulatory WCE. In 73 young...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283589ee6

    authors: Saladini F,Benetti E,Malipiero G,Casiglia E,Palatini P

    更新日期:2012-11-01 00:00:00

  • May subclinical arterial disease help to better detect and treat high-risk asymptomatic individuals?

    abstract::The diagnosis of high risk of cardiovascular disease (CVD) in subjects without clinically overt CVD has been somewhat improved by integrating multiple traditional risk factors via appropriate risk score programs. Nevertheless, novel measures of CVD risk are being proposed and debated to further improve high-risk detec...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/01.hjh.0000184407.20257.58

    authors: Simon A,Levenson J

    更新日期:2005-11-01 00:00:00

  • Effect of abdominal aortic grafts on aortic stiffness and central hemodynamics.

    abstract::Graft-prosthesis and stentgraft placements are effective modalities for treating abdominal aortic aneurysm, but related changes in arterial stiffness are not well established. The present study sought to assess aortic stiffness after aneurism repair by measuring pulse wave velocity (PWV). The graft-related variation o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283299b22

    authors: Lantelme P,Dzudie A,Milon H,Bricca G,Legedz L,Chevalier JM,Feugier P

    更新日期:2009-06-01 00:00:00

  • African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia.

    abstract:OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328364f5bc

    authors: Shibata D,Tillin T,Beauchamp N,Heasman J,Hughes AD,Park C,Gedroyc W,Chaturvedi N

    更新日期:2013-12-01 00:00:00

  • External validation and comparison of formulae estimating 24-h sodium intake from a fasting morning urine sample.

    abstract:OBJECTIVE:The relationship between sodium intake and cardiovascular events is controversial, but most large epidemiological studies estimated sodium intake using formulae based on single urine samples, the validity of which is debated. We evaluated sodium intake estimating formulae in a large cohort of adult patients. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001609

    authors: Vidal-Petiot E,Joseph A,Resche-Rigon M,Boutten A,Mullaert J,d' Ortho MP,Vrtovsnik F,Steg PG,Flamant M

    更新日期:2018-04-01 00:00:00

  • Anthropometric and lifestyle factors associated with white-coat, masked and sustained hypertension in a Chinese population.

    abstract:OBJECTIVE:We investigated to what extent anthropometric and lifestyle factors contributed to the classification of Chinese individuals into groups with white-coat, masked and sustained hypertension (HT). METHODS:We measured the office and ambulatory blood pressure (BP) in 694 Chinese enrolled in the JingNing populatio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282efeee7

    authors: Wang GL,Li Y,Staessen JA,Lu L,Wang JG

    更新日期:2007-12-01 00:00:00

  • Sodium transport kinetics in erythrocytes and inside-out vesicles from Milan rats.

    abstract::This paper describes the kinetics of the Na(+)-K+ pump and the Na(+)-K(+)-Cl- cotransport in sodium-loaded erythrocytes and of the Na(+)-K(+)-Cl- cotransport in erythrocyte inside-out vesicles (IOV) from Milan hypertensive (MHS) and normotensive (MNS) rats in order to evaluate the possible role of intracellular factor...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199108000-00003

    authors: Ferrari P,Torielli L,Cirillo M,Salardi S,Bianchi G

    更新日期:1991-08-01 00:00:00

  • Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs--overview and meta-analyses.

    abstract:BACKGROUND AND OBJECTIVES:In 68 randomized controlled trials (RCTs), blood pressure (BP) lowering was obtained by using drugs of different classes. We have investigated whether BP lowering by any of the major drug classes is effective in reducing the cardiovascular outcomes. METHODS:A total of 55 RCTs (19,5 267 indivi...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HJH.0000000000000447

    authors: Thomopoulos C,Parati G,Zanchetti A

    更新日期:2015-02-01 00:00:00

  • Early sexual experience and hypertension in US adults: results from the National Health and Nutrition Examination Survey 2001-2016.

    abstract:OBJECTIVES:We examined whether the early initiation of sexual activity is associated with hypertension in US adults, and whether the timing of first menstruation is meaningful in regard of this association. We also assessed the effect modification by ethnicity. METHODS:Using data from 2001 to 2016 National Health and ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001821

    authors: Ngueta G,Ndjaboue R

    更新日期:2018-12-01 00:00:00

  • Adjustment for current weight and the relationship between birth weight and blood pressure in childhood.

    abstract:OBJECTIVE:To determine the role of current weight in mediating the relationship between birth weight and blood pressure within the context of the 'fetal origins' hypothesis. DESIGN:Prospective cohort study of 2507 pregnant women and their singleton offspring, delivered live at term, in Perth, Western Australia between...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200018080-00003

    authors: Blake KV,Gurrin LC,Evans SF,Beilin LJ,Stanley FJ,Landau LI,Newnham JP

    更新日期:2000-08-01 00:00:00

  • Hypertension in blacks: insights from Africa.

    abstract::Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001171

    authors: Rayner BL,Spence JD

    更新日期:2017-02-01 00:00:00

  • Persistence and adherence to antihypertensive treatment in relation to initial prescription: diuretics versus other classes of antihypertensive drugs.

    abstract:BACKGROUND:The use of thiazide diuretics in the treatment of hypertension is widely considered as a first-line treatment, given the efficacy and low cost of this class of drugs. This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persist...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/HJH.0b013e328353398b

    authors: Trimarco V,de Simone G,Izzo R,De Luca N,Giudice R,Marino M,Damiano S,Rozza F,Trimarco B,Di Renzo G

    更新日期:2012-06-01 00:00:00

  • Norepinephrine-induced plasma dopamine decrease in man: pharmacological evidence of the involvement of alpha 2-adrenoceptors.

    abstract:OBJECTIVE:The purposes of this study were: (1) to test whether intravenous infusion of norepinephrine can affect plasma dopamine levels; and (2) to explore to what extent dopamine-2 or alpha 2-receptors play a role in this response. DESIGN:Norepinephrine infusion in man was performed to test whether the increase in no...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Musso NR,Gianrossi R,Vergassola C,Pende A,Ioverno A,Galbariggi G,Lotti G

    更新日期:1992-09-01 00:00:00

  • Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors.

    abstract:OBJECTIVE AND METHODS:The vasoactive properties of P1,P4-diadenosine tetraphosphate (Ap4A) were studied by measuring the effects of perfusion pressure of a rat isolated perfused kidney. RESULTS:The vasoconstrictive response to Ap4A was mediated to a large extent to a P2X receptor which could be shown by inhibition wit...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816121-00013

    authors: van der Giet M,Jankowski J,Schlüter H,Zidek W,Tepel M

    更新日期:1998-12-01 00:00:00

  • Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension.

    abstract:OBJECTIVES:The antihypertensive effect of thiazide diuretics in angiotensin II induced hypertension has never been characterized. In the current study, we sought to determine the effect of a thiazide diuretic on arterial pressure and renal fluid excretion in rats receiving a chronic intravenous infusion of angiotensin ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200109000-00012

    authors: Ballew JR,Fink GD

    更新日期:2001-09-01 00:00:00

  • Spectral analysis of the systolic blood pressure signal in secondary hypertension: a method for the identification of phaeochromocytoma.

    abstract:OBJECTIVE:To seek in hypertensive patients rhythmic variations of the systolic blood pressure signal obtained by ambulatory blood pressure monitoring of any inherent cycle of intermediate value between 1 and 24 h. DESIGN:Subjects (62 hypertensive, 39 normotensive) were evaluated by 24-h ambulatory blood pressure monit...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Meisel SR,Mor-Avi V,Rosenthal T,Akselrod S

    更新日期:1994-03-01 00:00:00

  • Loss of maximum attenuation and receptor reserve for isoprenaline at the beta 2-adrenoceptors of the portal veins of hypertensive rats.

    abstract:OBJECTIVE:To test the hypothesis that vascular beta 2-adrenoceptor hyporesponsiveness in spontaneously hypertensive rats (SHR) is not induced by increased blood pressure or venous hypertrophy. DESIGN:We compared the attenuating effects or isoprenaline, sodium nitroprusside and verapamilon the portal veins from Wistar-...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199509000-00013

    authors: Doggrell SA,Surman AJ

    更新日期:1995-09-01 00:00:00

  • Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.

    abstract:OBJECTIVE:This study tests the hypothesis that the transient receptor potential vanilloid subtype 1 channel induced neuropeptide secretion and depressor response are mediated by, at least in part, activation of endoplasmic reticulum associated Ca release receptors, leading to increased cytosolic Ca in dorsal root gangl...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328309eff9

    authors: Huang W,Wang H,Galligan JJ,Wang DH

    更新日期:2008-10-01 00:00:00

  • Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects.

    abstract:BACKGROUND:There are no studies that relate BsmI polymorphism of the vitamin D receptor (VDR) gene and with vitamin D to blood pressure (BP). OBJECTIVE:To analyze if this polymorphism and 25-hydroxyvitamin D levels (25OHD3) influence BP in a population of healthy subjects. DESIGN:Transversal study on healthy populati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000098139.70956.21

    authors: Muray S,Parisi E,Cardús A,Craver L,Fernández E

    更新日期:2003-11-01 00:00:00

  • The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism?

    abstract::Use of the aldosterone-to-renin ratio has controversially suggested that approximately 10% of hypertensives have primary aldosteronism, and most of these individuals are thought to have idiopathic hyperaldosteronism. The usual renin-angiotensin system control is intact in these individuals and is similar to that in lo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-200201000-00003

    authors: Lim PO,Struthers AD,MacDonald TM

    更新日期:2002-01-01 00:00:00

  • Blood pressure variability in subacute stage and risk of major vascular events in ischemic stroke survivors.

    abstract:BACKGROUND:We aimed to investigate whether blood pressure (BP) in the subacute stage of ischemic stroke affects subsequent vascular events after acute ischemic stroke. METHODS:From a prospective stroke registry database, consecutive ischemic stroke patients arriving within 48 h of onset were identified. The mean and S...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002126

    authors: Kang J,Kim BJ,Yang MH,Jang MS,Han MK,Lee JS,Gorelick PB,Lee J,Bae HJ

    更新日期:2019-10-01 00:00:00

  • Serum ionized calcium and pH: effects of blood storage, some physiological influences and a comparison between normotensive and hypertensive subjects.

    abstract::The effects on serum ionized calcium (ICa) and pH of different storage conditions of blood or serum, and of physiological influences such as over-ventilation, food intake and dietary sodium intake have been investigated. Temperature and time-related changes in ICa occurred with storage and were minimized by immediate ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Shore AC,Booker J,Sagnella GA,Markandu ND,MacGregor GA

    更新日期:1987-08-01 00:00:00

  • Night-time heart rate nondipping: clinical and prognostic significance in the general population.

    abstract:AIM:Studies addressing the association between a reduced drop of heart rate (HR) at night with subclinical organ damage and cardiovascular events in the general population are scanty. We evaluated this issue in individuals enrolled in the Pressioni Monitorate E Loro Associazioni study. METHODS:At entry, 2021 individua...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001703

    authors: Cuspidi C,Facchetti R,Bombelli M,Sala C,Tadic M,Grassi G,Mancia G

    更新日期:2018-06-01 00:00:00

  • Hypertension caused by chronic intermittent hypoxia--influence of chemoreceptors and sympathetic nervous system.

    abstract:BACKGROUND:The sleep apnea syndrome (SAS) is a common health problem with a 30% prevalence among patients with so-called essential hypertension. OBJECTIVE:Prompted by this epidemiologic link we tried to find out whether there is a cause-effect relationship between SAS and systemic hypertension. DESIGN:We developed an...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715120-00060

    authors: Lesske J,Fletcher EC,Bao G,Unger T

    更新日期:1997-12-01 00:00:00

  • Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries.

    abstract:BACKGROUND AND OBJECTIVES:Although 24-h urinary measure to estimate sodium and potassium excretion is the gold standard, it is not practical for large studies. We compared estimates of 24-h sodium and potassium excretion from a single morning fasting urine (MFU) using three different formulae in healthy individuals. M...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000122

    authors: Mente A,O'Donnell MJ,Dagenais G,Wielgosz A,Lear SA,McQueen MJ,Jiang Y,Xingyu W,Jian B,Calik KB,Akalin AA,Mony P,Devanath A,Yusufali AH,Lopez-Jaramillo P,Avezum A Jr,Yusoff K,Rosengren A,Kruger L,Orlandini A,Rangar

    更新日期:2014-05-01 00:00:00

  • Accutracker II (version 30/23) ambulatory blood pressure monitor: clinical validation using the British Hypertension Society and Association for the Advancement of Medical Instrumentation standards.

    abstract:OBJECTIVE:To assess the Accutracker II (version 30/23) ambulatory blood pressure monitor by nationally agreed protocols in order to resolve previous conflicting assessments, and to examine the feasibility of combining these protocols into one study. DESIGN:The protocols of the Association for the Advancement of Medica...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Taylor R,Chidley K,Goodwin J,Broeders M,Kirby B

    更新日期:1993-11-01 00:00:00

  • Kinetic study of the Ca2+ pump in erythrocytes from essential hypertensive patients.

    abstract::Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

    更新日期:1990-03-01 00:00:00

  • Exaggerated blood pressure response to exercise is associated with carotid atherosclerosis in apparently healthy men.

    abstract:OBJECTIVE:Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sec...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000222758.54111.e2

    authors: Jae SY,Fernhall B,Heffernan KS,Kang M,Lee MK,Choi YH,Hong KP,Ahn ES,Park WH

    更新日期:2006-05-01 00:00:00

  • Red blood cell Na content, Na, Li-countertransport, family history of hypertension and blood pressure in school children.

    abstract::This study focuses on the relationship between some aspects of intra-erythrocytic sodium metabolism (intra-erythrocytic Na content, Na,Li-countertransport), blood pressure, and family history of hypertension, in a group of 84 randomly selected school children (45 males, 39 females). Na,Li-countertransport was signific...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198803000-00007

    authors: Trevisan M,Strazzullo P,Cappuccio FP,Di Muro MR,De Colle S,Franzese A,Iacone R,Krogh V

    更新日期:1988-03-01 00:00:00

  • Effects of prolonged and brief infusions of noradrenaline on arterial pressure and on the plasma concentrations of active renin, angiotensin II, aldosterone and potassium.

    abstract::Conscious male beagle dogs were given constant intravenous infusions of noradrenaline for 14 days, four receiving 125 ng/kg/min and four 250 ng/kg/min. Before, during and after these infusions dose-response studies were done in which additional noradrenaline was infused at 500, 1000 and 2000 ng/kg/min, each rate for 1...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Casals-Stenzel J,Tree M,Brown JJ,Fraser R,Lever AF,Millar JA,Morton JJ,Robertson JI,Reid JL,Hamilton C

    更新日期:1983-06-01 00:00:00