Abstract:
:Networks synthesized through thiol-acrylate photopolymerization or Michael-type addition step growth reactions contain esters with neighboring sulfide groups. Previous work has demonstrated that these esters are readily hydrolyzable at physiological pH. Here, the influence of the distance between the sulfide and ester, as well as the water concentration, on ester hydrolysis was characterized. These preliminary results indicate that reducing the number of carbons between the sulfide and the ester from 2 to 1 increased the rate of ester hydrolysis from 0.022+/-0.001 to 0.08+/-0.015days(-1). Increases in ester hydrolysis rates were also observed as hydrophilicity increased for oligomers prepared from a trithiol, tetrathiol and dithiol monomer (0.012+/-0.003, 0.032+/-0.004, and 0.091+/-0.003days(-1), respectively). Additionally, in bulk-eroding polymeric biomaterials, variations in pH impacted the ester hydrolysis rate. This work confirms that small variations in buffer pH predictably alter the mass loss profile of a thiol-acrylate photopolymer. More specifically, as buffer pH was changed from 7.4 to 8.0, the rate of ester hydrolysis increased from 0.074+/-0.003 to 0.28+/-0.005days(-1). The magnitude of this observed change in ester hydrolysis rate was correlated to the increase in hydroxide ion concentration that accompanied this pH change.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Rydholm AE,Anseth KS,Bowman CNdoi
10.1016/j.actbio.2006.12.001subject
Has Abstractpub_date
2007-07-01 00:00:00pages
449-55issue
4eissn
1742-7061issn
1878-7568pii
S1742-7061(06)00159-0journal_volume
3pub_type
杂志文章abstract::Tissue engineering is an ideal therapeutic strategy for the development of functional tendon replacement tissue for tendon repair in the clinic. Currently, the synergistic roles of mechano-chemical factors and the mechanisms involved in tendon repair and regeneration are not fully understood. In this study, we develop...
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journal_title:Acta biomaterialia
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doi:10.1016/j.actbio.2007.10.010
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journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
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