当前位置： SCI文献检索 > BIOCHEMICAL PHARMACOLOGY期刊下所有文献 > A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).

A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).

Abstract：

:a synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Müller A,Cadenas E,Graf P,Sies H

doi

10.1016/0006-2952(84)90083-2

subject

Has Abstract

pub_date

1984-10-15 00:00:00

pages

3235-9

issue

20

eissn

0006-2952

issn

1873-2968

pii

0006-2952(84)90083-2

journal_volume

33

pub_type

杂志文章

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