Radiation-induced sarcoma of bone: clinical and radiographic findings in 43 patients irradiated for soft tissue neoplasms.

Abstract:

:Sarcomas rarely follow irradiation of benign lesions of bone as the dangers of this form of therapy is well recognised. Forty-three patients with soft tissue neoplasms - mainly carcinoma - were irradiated and developed sarcomas in the radiation field. Twenty-four of these patients were seen at this centre in the last decade, a considerable increase compared to earlier years. Radiation osteitis may indicate the nature of the tumour but was only present in 50%. A purely lytic or purely sclerotic pattern was commoner than a mixed lytic and sclerotic appearance. CT scan, bone scan and angiography were helpful in delineating disease but did not assist in diagnosing the type of tumour. A tumour arising within the irradiated field is an indication for biopsy. Prognosis of radiation-induced sarcoma (RIS) remains poor, only five of the 43 patients survived 5 years.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Smith J

doi

10.1016/s0009-9260(82)80065-2

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

205-21

issue

2

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(82)80065-2

journal_volume

33

pub_type

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