Abstract：
PURPOSE:To investigate the potential of a novel lipid carrier, comprising beads of alpha-cyclodextrin and soybean oil, for topical drug delivery. Adapalene was chosen as a model drug to explore the ability of the beads to encapsulate and release a highly lipophilic compound. MATERIALS AND METHODS:Adapalene-loaded beads were prepared and characterised. Skin tolerance to unloaded beads was tested on human volunteers, while drug release and delivery into stratum corneum, was evaluated in pig skin ex vivo. RESULTS:The preparation and physical characteristics of the beads were not dependent on whether adapalene had been previously dissolved or dispersed in soybean oil. Drug encapsulation efficiency was high (>96%) and drug loading on the order of a therapeutic level could be achieved in freeze-dried beads prepared from an oily dispersion of adapalene. After application to human skin, unloaded beads induced no adverse reaction and were better tolerated than an alcoholic gel. Tape-stripping the stratum corneum from treated pig skin showed that adapalene release and penetration from the beads was comparable to that from gel and cream formulations available on the market. CONCLUSION:These novel beads may offer a well-tolerated and efficient system for the encapsulation and topical delivery of lipophilic drugs.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Trichard L,Delgado-Charro MB,Guy RH,Fattal E,Bochot Adoi
10.1007/s11095-007-9395-0subject
Has Abstractpub_date
2008-02-01 00:00:00pages
435-40issue
2eissn
0724-8741issn
1573-904Xjournal_volume
25pub_type
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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更新日期：2019-07-31 00:00:00
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更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-03-01 00:00:00
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更新日期：2013-06-01 00:00:00
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journal_title：Pharmaceutical research
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更新日期：2000-01-01 00:00:00
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journal_title：Pharmaceutical research
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