Apigenin: a promising molecule for cancer prevention.

abstract：:The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic interconversion-tri...

journal_title：Pharmaceutical research

authors： McGee JP,Shaw PN

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:For the assessment of bioequivalence it is assumed that drug clearance in each subject on each of the study days is the same and any observed differences in AUC and/or Cmax between a brand and generic formulation are due to differences in bioavailability. We hypothesized that this assumption was invalid for hig...

journal_title：Pharmaceutical research

authors： Tsang YC,Pop R,Gordon P,Hems J,Spino M

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To investigate the influence of nanocarrier molecular size and shape on breast duct retention in normal rats using a non-invasive optical imaging method. METHODS:Fluorescein-labeled PEG nanocarriers of different molecular weights and shapes (linear, two-arm, four-arm, and eight-arm) were intraductally administ...

journal_title：Pharmaceutical research

authors： Singh Y,Gao D,Gu Z,Li S,Rivera KA,Stein S,Love S,Sinko PJ

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:To describe a computational tool to calculate molecular descriptors of potential application in ADME virtual screening of antitumor Pt(II) drug candidates. METHODS:The multistep computational procedure consists in (a) building and optimization (PM3) of the 3D structures of the investigated complexes, (b) param...

journal_title：Pharmaceutical research

authors： Caron G,Ravera M,Ermondi G

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:The main goal of this research was to assess the mechanical properties of APIs' polymorphic forms at the single-crystal level (piroxicam, famotidine, nifedipine, olanzapine) in order to predict their bulk deformational attributes, which are critical for some pharmaceutical technology processes. METHODS:The mec...

journal_title：Pharmaceutical research

authors： Egart M,Janković B,Lah N,Ilić I,Srčič S

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to clarify the localization and function of the ATP-binding cassette transporter G2 (ABCG2; BCRP/MXR/ABCP) in retinal capillary endothelial cells, which form the inner blood-retinal barrier, as an efflux transport system. METHODS:The expression was determined by reverse transcript...

journal_title：Pharmaceutical research

authors： Asashima T,Hori S,Ohtsuki S,Tachikawa M,Watanabe M,Mukai C,Kitagaki S,Miyakoshi N,Terasaki T

更新日期：2006-06-01 00:00:00

abstract：:Nucleoside transporters play a critical role in the absorption, disposition, and targeting of therapeutically used nucleosides and nucleoside analogs. This review is focused on the Na(+)-dependent, concentrative nucleoside transporters which are found in a variety of cells including renal, intestinal and hepatic epith...

journal_title：Pharmaceutical research

authors： Wang J,Schaner ME,Thomassen S,Su SF,Piquette-Miller M,Giacomini KM

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:The purpose of this work was to investigate the mechanisms of cocrystal formation during cogrinding and storage of solid reactants, and to establish the effects of water by cogrinding with hydrated form of reactants and varying RH conditions during storage. METHODS:The hydrogen bonded 1:1 carbamazepine-sacchar...

journal_title：Pharmaceutical research

authors： Jayasankar A,Somwangthanaroj A,Shao ZJ,Rodríguez-Hornedo N

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:We examined the subcellular distribution of the basic drugs, chlorpromazine (CPZ), imipramine (IMP) and biperiden (BP), in rat liver, and evaluated the contribution of lysosome (Lys) to their intracellular distribution in comparison with that of mitochondria (Mit). METHODS:In an in vivo distribution, the conce...

journal_title：Pharmaceutical research

authors： Ishizaki J,Yokogawa K,Hirano M,Nakashima E,Sai Y,Ohkuma S,Ohshima T,Ichimura F

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:Adjuvants are required to ensure the efficacy of subunit vaccines. Incorporating molecular immunopotentiators within particles could overcome drawbacks of molecular adjuvants (such as solubility and toxicity), and improve adjuvanticity of particles, achieving stronger adjuvant activity. Aim of this study is to ...

journal_title：Pharmaceutical research

authors： Zhang W,Wang L,Yang T,Liu Y,Chen X,Liu Q,Jia J,Ma G

更新日期：2015-09-01 00:00:00

abstract：:The limitations of traditional gas adsorption models for describing water vapor sorption by amorphous pharmaceutical solids are described and an alternative approach based on polymer solution theories is proposed. The approach is tested by comparing a priori predicted isotherms with literature data for the poly(vinylp...

journal_title：Pharmaceutical research

authors： Hancock BC,Zografi G

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:Oral bioavailability for antisense oligonucleotides has recently been reported but the mechanistic details are not known. The proposed oral delivery of nucleic acids will, therefore, require an understanding of the membrane binding interactions, cell uptake and transport of oligonucleotides across the human gas...

journal_title：Pharmaceutical research

authors： Beck GF,Irwin WJ,Nicklin PL,Akhtar S

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:The purpose of this human intestinal perfusion study was to investigate the transport and metabolism of R/S-verapamil in the human jejunum (in vivo). METHODS:A regional single-pass perfusion of the jejunum was performed using a Loc-I-Gut perfusion tube in 12 healthy volunteers. Each perfusion lasted for 200 mi...

journal_title：Pharmaceutical research

authors： Sandström R,Karlsson A,Knutson L,Lennernäs H

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The objective of this study was to investigate the possible influence of probenecid on morphine transport across the blood-brain barrier (BBB) in rats. METHODS:Microdialysis probes, calibrated using retrodialysis by drug, were placed into the striatum and jugular vein of seven Sprague-Dawley rats. Morphine was...

journal_title：Pharmaceutical research

authors： Tunblad K,Jonsson EN,Hammarlund-Udenaes M

更新日期：2003-04-01 00:00:00

abstract：:Various diesters of 9-[(1,3-dihydroxy-2-propoxy)-methyl]guanine (DHPG) were screened in order to identify a derivative with improved oral absorption. The solubilities and dissolution rates decreased with increasing chain length and branching of the ester group. However, the dipropionate ester showed an anomalously fas...

journal_title：Pharmaceutical research

authors： Benjamin EJ,Firestone BA,Bergstrom R,Fass M,Massey I,Tsina I,Lin YY

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:The cause of antibody positive pure red cell aplasia associated with the subcutaneous administration of EPREX to patients with chronic kidney failure has been determined to be due to the leaching of weakly adjuvant compounds from the uncoated rubber stoppers that were formerly used in prefilled syringes. Other ...

journal_title：Pharmaceutical research

authors： Villalobos AP,Gunturi SR,Heavner GA

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Evista (raloxifene HCl) is a nonsteroidal selective estrogen receptor modulator that displays estrogen agonist effects on bone and lipid metabolism but estrogen antagonist effects on the breast and endometrium. The potential for drug-drug interaction between raloxifene and warfarin was assessed in 15 healthy po...

journal_title：Pharmaceutical research

authors： Miller JW,Skerjanec A,Knadler MP,Ghosh A,Allerheiligen SR

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Desmopressin acetate (DDAVP) is used parenterally and intranasally in the control of several diseases. Oral administration of DDAVP, while most desirable, is not practical presently due to low bioavailability. The objective of the present study was to explore the feasibility for employing oil-in-water MucoAdhes...

journal_title：Pharmaceutical research

authors： Ilan E,Amselem S,Weisspapir M,Schwarz J,Yogev A,Zawoznik E,Friedman D

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:The objective of the work was to evaluate the potential of hyaluronan-based nanoparticles as tumor-targeting nano-systems for CD44-overexpressed cancer therapy. METHODS:The synthesized amphiphilic cholesteryl succinoyl hyaluronan (Chol-Suc-HA) conjugates self-assembled into docetaxel(DTX)-loaded nanoparticles ...

journal_title：Pharmaceutical research

authors： Song S,Qi H,Xu J,Guo P,Chen F,Li F,Yang X,Sheng N,Wu Y,Pan W

更新日期：2014-11-01 00:00:00

abstract：:Antibody drug conjugates (ADCs) are a class of therapeutics that combine the target specificity of an antibody with the potency of a chemotherapeutic. This therapeutic strategy can significantly expand the therapeutic index of a chemotherapeutic by minimizing the systemic exposure and associated toxicity of the chemot...

journal_title：Pharmaceutical research

authors： Lin K,Tibbitts J

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:To develop a semi-mechanistic population pharmacokinetic model based on gastric emptying function for acetaminophen plasma concentration in critically ill patients tolerant and intolerant to enteral nutrition before and after prokinetic therapy. METHODS:Acetaminophen plasma concentrations were available from a...

journal_title：Pharmaceutical research

authors： Ogungbenro K,Vasist L,Maclaren R,Dukes G,Young M,Aarons L

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To evaluate organic anion transporter-mediated drug-drug interaction (DDI) potential for individual active components of Danshen (Salvia miltiorrhiza) vs. combinations using in vitro and in silico approaches. METHODS:Inhibition profiles for single Danshen components and combinations were generated in stably-ex...

journal_title：Pharmaceutical research

authors： Wang L,Venitz J,Sweet DH

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Since the molecular mechanism of the cell cycle was established, various theoretical models of this process have been developed. A recent study revealed significant variability in cell cycle duration between mother and daughter cells, but this observation has not been incorporated into the theoretical models. ...

journal_title：Pharmaceutical research

authors： Bae H,Go YH,Kwon T,Sung BJ,Cha HJ

更新日期：2019-02-22 00:00:00

abstract：PURPOSE:For determination of the transit time through various parts of the gastrointestinal (GI) tract, we developed a method that provides the location of disintegration and drug release. This method involves GI magnetomarkergraphy (GIMG) using a 129-channel Shimadzu vector biomagnetic measurement system (BMS). METHO...

journal_title：Pharmaceutical research

authors： Hu Z,Mawatari S,Shibata N,Takada K,Yoshikawa H,Arakawa A,Yosida Y

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:We have shown that the three human prostate xenograft tumors, i.e. the androgen-dependent CWR22 tumor, and the androgen-resistant CWR22R and CWR91 tumors, are comparable to patient tumors in their expression of prostate specific antigen, multidrug resistance p-glycoprotein, p53 and Bcl-2 and in their sensitivit...

journal_title：Pharmaceutical research

authors： Gan Y,Au JL,Lu J,Wientjes MG

更新日期：1998-11-01 00:00:00

abstract：:Prinomide tromethamine, a nonsteroidal antiinflammatory drug, was orally administered at doses of 250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers. The pharmacokinetic behavior of prinomide and its primary plasma metabolite displayed nonlinear characteristics, while those of free prinomide and ...

journal_title：Pharmaceutical research

authors： Kochak GM,Pai S,Iannucci R,Honc F,Kachmar D,Perrino P,Egger H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Multidrug and toxin extrusion proteins (MATEs) are multispecific organic cation transporters mediating the efflux of various cationic drugs into the urine. The present study aimed at identifying endogenous compounds in human plasma and urine specimens as biomarkers to evaluate drug interactions involving MATEs ...

journal_title：Pharmaceutical research

authors： Kato K,Mori H,Kito T,Yokochi M,Ito S,Inoue K,Yonezawa A,Katsura T,Kumagai Y,Yuasa H,Moriyama Y,Inui K,Kusuhara H,Sugiyama Y

更新日期：2014-01-01 00:00:00

abstract：:The crystal growth kinetics of theophylline monohydrate from aqueous buffered supersaturated solutions were investigated at 10, 20, 30, and 40 degrees C. Crystallization experiments were carried out isothermally at pH 6. During growth the crystal count and size distributions were monitored in situ. The growth rate was...

journal_title：Pharmaceutical research

authors： Rodríguez-Hornedo N,Wu HJ

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:Cell-based permeability screens are widely used to identify drug-P-glycoprotein (PGP) interaction in vitro. However, their reliability in predicting the impact of PGP on human drug pharmacokinetics is poorly defined. The aim was to determine whether a quantitative relationship exists between PGP-mediated altera...

journal_title：Pharmaceutical research

authors： Collett A,Tanianis-Hughes J,Hallifax D,Warhurst G

更新日期：2004-05-01 00:00:00

abstract：:To clarify the mechanism by which basic drugs accumulate in the lung, the binding selectivity of drugs to different subcellular structures of the perfused rat lung was examined. Imipramine, quinine, and metoclopramide were used as examples of basic drugs. The accumulation of basic drugs was highest in the mitochondria...

journal_title：Pharmaceutical research

authors： Yoshida H,Okumura K,Hori R

更新日期：1987-02-01 00:00:00