Abstract:
:The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic interconversion-trilostane producing ketotrilostane and ketotrilostane generating trilostane. This result means that trilostane is conserved in the body by interconversion--being metabolized to ketotrilostane and then subsequently back to the "parent" drug, trilostane.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
McGee JP,Shaw PNdoi
10.1023/a:1015828027060subject
Has Abstractpub_date
1992-04-01 00:00:00pages
464-8issue
4eissn
0724-8741issn
1573-904Xjournal_volume
9pub_type
杂志文章abstract::The release of lithium carbonate incorporated into polymethylmethacrylate, polyvinyl chloride, hydrogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-rel...
journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2007-06-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:1996-07-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2004-10-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2006-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2009-10-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 临床试验,杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00