Abstract：
:Azathiprine (0.25 mg/100 g body wt.) and cyclophosphamide (0.2 mg/100 g body wt.) were administered to guinea pigs, orally every day during 4 weeks. Azathioprine caused a decrease in total collagen content in skin, liver and bone and decreased hydroxyproline and hydroxylysine concentration in blood serum, and urinary excretion of collagen catabolites. No effect of cyclophosphamide on total collagen in skin and liver was observed. An increase in collagen content in bone in cyclophosphamide-treated guinea pigs was found. A decrease of hydroxyproline and hydroxylysine in blood serum and urine was observed after cyclophosphamide treatment. The results support the view that cytostatic drugs inhibit collagen metabolism, and azathioprine significantly affects collagen biosynthesis, and cyclophosphamide influences inhibition of catabolic processes of collagen.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Drózdz M,Kucharz Esubject
Has Abstractpub_date
1977-01-01 00:00:00pages
773-8issue
6eissn
0004-069Xissn
1661-4917journal_volume
25pub_type
杂志文章abstract：:The production of sheep Pseudomonas immune serum is described. The animals were immunized with Pseudomonas vaccine prepared from strains of Pseudomonas aeruginosa belonging to seven immunotypes of Fisher's schema. Immune sera obtained from hyperimmunized sheep are characterized by a high level of stabel antibodies wit...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:12 children with acute lymphoblastic leukemia remaining in remission for 1-3 years, were studied during levamisol therapy. T-lymphocytes count, phagocytic activity of granulocytes the adherent cell number were investigated. The clinical state of patients before, during and after levamisol treatment was evaluated. The ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesen...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-017-0493-3
更新日期：2018-08-01 00:00:00
abstract：:The KIR2DL4 receptor and its ligand HLA-G are considered important for fetal-maternal immune tolerance and successful pregnancy. The absence of a particular variant of KIR2DL4 might be a bad prognostic factor for pregnancy outcome. However, it could be compensated by the presence of the respective LILRB1 allele. There...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-016-0389-7
更新日期：2016-12-01 00:00:00
abstract：:2538 strains of Shigella sonnei bacilli, isolated from patients in the years 1959-1972, have been tested for drug-resistance. The strains examined came from different regions of Poland. Drug-resistance has been determined by the method of "multi-arm" disks of filter-paper. In investigations 12 chemotherapeutics have b...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Distribution of cytochrome P450 2C19 enzyme gene (CYP2C19) variants affecting metabolism of clopidogrel was determined in 526 Czech patients after percutaneous coronary intervention using MassARRAY genotyping and compared to distribution in other populations of European descent. Fifty-three (10%) patients underwent pa...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-016-0440-8
更新日期：2016-12-01 00:00:00
abstract：:Flow-mediated dilation (FMD) represents a non-invasive marker of endothelial function to evaluate vascular homeostasis, which reflects the effects of several mechanisms, including vessel tone regulation, cell proliferation, and inflammatory responses. Beyond classical atherosclerotic risk factors such as arterial hype...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-017-0465-7
更新日期：2017-12-01 00:00:00
abstract：:Two week old chickens were treated once daily for 5 days with AE8--1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22--bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31--bis(phenylo-diselenide with R3 = CONHC18H37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Sera from 14 of 50 patients suffering from bronchial asthma complicated by suppurative catarrh of the respiratory tract contained antibodies to homologous and heterologous gamma-globulins. The findings were attributed to hyperimmunization causing changed in antigenic properties of antibodies. Antigenically altered ant...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Distribution of esterase D types was studied in a sample of the Polish population numbering 885 subjects. Frequency of EsDl-1 type was 0.810, EsD2-1 -- 0.174, and EsD2-2 -- 0.16. Frequency of the genes EsD1 and EsD2, which determine this system, were 0.897 and 0.103 respectively. A study of 613 mother-child pairs reve...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:There is a strong epidemiologic relationship between chronic hepatitis C virus (HCV) infection and the development of hepatocellular carcinoma, although the cellular and molecular mechanisms of tumor formation remain to be firmly established. Clearly, HCV is associated with the development of chronic hepatitis and cir...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：:The chemotactic activity of elastin-derived peptides (EP) for human polymorphonuclear leukocytes (PMNL) was investigated using the under agarose method. The EP were produced by digesting the bovine ligament elastin with porcine pancreatic elastase. Thus prepared digest had weak chemotactic activity for PMNL. The mean ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Colonization of the gastrointestinal tract with multidrug-resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL(+) and Escherichia coli ESBL(+) gut colonization in the immunocompromised host as a novel...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 信件
doi：10.1007/s00005-016-0387-9
更新日期：2016-06-01 00:00:00
abstract：:The objective of our study was to evaluate the impact of sex and age on the prevalence of sensitization to inhalant allergens. The study was performed as a part of Polish Epidemiology of Allergic Diseases study, and data concerning citizens of Wroclaw were analyzed. The participants were divided into three age groups ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-016-0425-7
更新日期：2017-06-01 00:00:00
abstract：:The influence of ATP and AMP injected into the lateral cerebral ventricle in doses of 50, 100 and 200 mug on behavior in rats was studied. ATP in the doses administered had no effect on behavior of rats. AMP in these doses enhanced motor activity of the rats. Chemical sympathectomy by intracerebral injection of 6-hydr...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:A line of AKR leukemic mouse cells cultured in vitro, designated AKR 87, was established and characterized. Two types of cells were distinguished in this line fibroblasts and lymphoblasts. The lymphoblast-like cells resembled the original tumor cells spontaneous leukemia of AKR mice. In the XC test, cells of this line...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Determinations of the blood serum levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and their soluble receptors (sIL-6R, sTNFR) in denture stomatitis patients (DS) were performed. Serum levels of interleukins and their soluble receptors were measured using the ELISA method. In all examined patien...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Appropriate combinations of immunotherapy and gene therapy promise to be more effective in the treatment of cancer patients than either of these therapeutic approaches alone. One such treatment is based on the application of patients' cytotoxic T cells, which can be activated, expanded, and genetically engineered to r...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-010-0091-0
更新日期：2010-10-01 00:00:00
abstract：:Herpes simplex and zoster are frequent skin diseases of viral origin and the mechanism of their development as well as their course are not yet fully known. Fully effective methods of treating these diseases are not known. The authors evaluated the results of the externally applied ITCL preparation in the form of a 2%...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to d...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-010-0083-0
更新日期：2010-08-01 00:00:00
abstract：:Influenza virus A/USSR/053/74/H3N2 was subjected to the effect of some physico-chemical factors: freezing-thawing, ultrasounds, long-term storage at 4 degrees C, hydrogen ions, formaldehyde. All the preparations were tested for virus infectivity, hemagglutinin titer, neuraminidase activity and ability of altered virus...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:T cell epitope-driven vaccine design employs bioinformatic algorithms to identify potential targets of vaccines against infectious diseases or cancer. Potential epitopes can be identified with major histocompatibility complex (MHC)-binding algorithms, and the ability to bind to MHC class I or class II indicates a pred...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-010-0067-0
更新日期：2010-04-01 00:00:00
abstract：:Impairment of interferon (IFN) system in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) became a basis for searching IFN responses to monitor the disease progression. For detailed investigations 16 HIV+/AIDS patients with at least 4 successively taken blood samples available...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The activity of neutral glucoamylase and alpha-amylase were determined in the myocardium and skeletal muscle after in vivo pharmacologic stimulation of adrenergic receptors. The activity changes of these enzymes were found to not always occur parallelly. The activity of both these enzymes is decreased under beta-agoni...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:32P-cyclophosphamide was found to combine with gamma-globulin fractions of immune sera. Immune sera incubated with 32P-cyclophosphamide retained ability to react specifically with homologous antigen in vitro in the system: MN antigens of human erythrocytes + rabbit anti-MN antibody, and probably reacted selectively w...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER) stress-induced cytotoxicity, and antioxidant activity owing to their activity as free radical scavengers, inhibition of coenzyme Q synthesis, activation of antio...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-017-0459-5
更新日期：2017-08-01 00:00:00
abstract：:Using the serial dilution method in solid media, sensitivity of isolated strains of S. aureus and E. coli to phosphonomycin, streptomycin, penicillin G and ampicillin, and the effect of combined action of phosphonomycin with these antibiotics were studied. Against S. aureus strains, phosphonomycin in combination with ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Tissue distribution of non-Lyt1.1 ("Ly10-like") antigen or antigens encoded by short chromosomal segment differentiating B6-Ly-1a congenic strain from B6 strain of mice was studied by quantitative absorption of (BALB/c X B6)F1 anti B6-Ly-1a antiserum and by direct cytotoxicity of Ly-10-132-12-26 monoclonal antibody on...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Umbilical cord blood transplantation (UCBT) is known to be associated with increased risk of infections, compared to bone marrow or peripheral blood stem cell transplantation. In viral diseases for which specific treatment is available, real-time PCR assays are reliable diagnostic tools for timely initiation of approp...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-010-0096-8
更新日期：2010-12-01 00:00:00
abstract：:The study group consisted of 13 patients, including 5 in complete remission and 8 in incomplete hematologic remission. Six patients had a pause in therapy, and the remaining ones were continuing maintenance therapy. In all cases production of IgG, IgA and IgM immunoglobulins was maintained. Response of lymphocytes to ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
