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Prognostic value of dipyridamole stress cardiovascular magnetic resonance imaging in patients with known or suspected coronary artery disease.

Abstract：

OBJECTIVES:We evaluated the prognostic value of dipyridamole stress cardiovascular magnetic resonance imaging (CMR) in patients with chest pain and known or suspected coronary artery disease. BACKGROUND:Stress perfusion CMR has been incorporated in daily practice. Data on its prognostic value are preliminary. METHODS:Dipyridamole stress CMR was performed in 420 patients with chest pain and known or suspected coronary artery disease. The extent (number of segments according to the 17-segment model) of abnormal wall motion at rest (AWM-rest), abnormal wall motion with dipyridamole (AWM-D), perfusion deficit (at stress first-pass perfusion imaging), and delayed enhancement (at late enhancement imaging) were analyzed. RESULTS:During a median follow-up of 420 days, 41 major adverse cardiac events (MACE), including 9 cardiac deaths, 14 nonfatal myocardial infarctions, and 18 readmissions for unstable angina with documented abnormal angiography, were documented. The MACE were more frequent in patients with significant (>1 segment) AWM-rest (22% vs. 5%), AWM-D (21% vs. 4%), perfusion deficit (17% vs. 5%), and delayed enhancement (20% vs. 6%; p <0.0001 in all cases). In a multivariate analysis adjusted for baseline characteristics, the extent of AWM-D was independently related to MACE (hazard ratio [HR] 1.15 [95% confidence interval (CI) 1.06 to 1.24] per segment; p = 0.0006) and to major events (cardiac death or nonfatal myocardial infarction; HR 1.15 [95% CI 1.05 to 1.26] per segment; p = 0.002). CONCLUSIONS:Dipyridamole stress CMR is useful for predicting the outcome of patients with known or suspected coronary artery disease.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Bodi V,Sanchis J,Lopez-Lereu MP,Nunez J,Mainar L,Monmeneu JV,Husser O,Dominguez E,Chorro FJ,Llacer A

doi

10.1016/j.jacc.2007.06.016

subject

Has Abstract

pub_date

2007-09-18 00:00:00

pages

1174-9

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(07)02076-1

journal_volume

pub_type

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Prognostic value of dipyridamole stress cardiovascular magnetic resonance imaging in patients with known or suspected coronary artery disease.