Treatment of symptomatic lower extremity acute deep venous thrombosis: role of mechanical thrombectomy.

Abstract:

:Systemic anticoagulation with heparin or its unfractionated derivatives followed by warfarin therapy has been the mainstay of treatment in patients with lower extremity deep venous thrombosis (DVT). Although heparin is an effective treatment modality in preventing thrombus propagation, it provides minimal therapeutic effect in dissolving preexisting venous thrombus. The clinical consequence of DVT, owing in part to loss of venous endothelial and valvular function, is postphlebitic syndrome or chronic venous insufficiency. Current advances in endovascular therapy have resulted in various endovascular thrombectomy systems that can effectively remove a large venous thrombus burden, which may represent a potential advantage of preserving venous valvular function and thereby reduce the likelihood of postphlebitic syndrome. In this article, we review a variety of surgical and interventional methods in venous thrombus removal. Current treatment modalities using mechanical thrombectomy devices and pharmacomechancial thrombectomy strategy are also discussed.

journal_name

Vascular

journal_title

Vascular

authors

Biuckians A,Meier GH 3rd

doi

10.2310/6670.2007.00070

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

297-303

issue

5

eissn

1708-5381

issn

1708-539X

journal_volume

15

pub_type

杂志文章,评审

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