Abstract:
OBJECTIVE:To evaluate the possibility of using heparin-bonded polycaprolactone grafts to replace small-diameter arteries. METHODS:Polycaprolactone was bonded with heparin. The activated partial thromboplastin time of heparin-bonded polycaprolactone grafts was determined in vitro. Small-diameter grafts were electrospun with heparin-bonded polycaprolactone and polycaprolactone and were implanted in dogs to substitute part of the femoral artery. Angiography was used to investigate the patency and aneurysm of the grafts after transplantation. After angiography, the patent grafts were explanted for histology analysis. The degradation of the grafts and the collagen content of the grafts were measured. RESULTS:Activated partial thromboplastin time tests in vitro showed that heparin-bonded polycaprolactone grafts exhibit obvious anticoagulation. Arteriography showed that two heparin-bonded polycaprolactone and three polycaprolactone grafts were obstructed. Other grafts were patent, without aneurysm formation. Histological analysis showed that the tested grafts degraded evidently over the implantation time and that the luminal surface of the tested grafts had become covered by endothelial cells. Collagen deposition in heparin-bonded polycaprolactone increased with time. There were no calcifications in the grafts. Gel permeation chromatography showed the heparin-bonded polycaprolactone explants at 12 weeks lose about 32% for Mw and 24% for Mn. The collagen content on the heparin-bonded polycaprolactone grafts increased over time. CONCLUSION:This preliminary study demonstrates that heparin-bonded polycaprolactone is a suitable graft for small artery reconstruction. However, heparin-bonded polycaprolactone degrades more rapidly than polycaprolactone in vivo.
journal_name
Vascularjournal_title
Vascularauthors
Duan HY,Ye L,Wu X,Guan Q,Yang XF,Han F,Liang N,Wang ZF,Wang ZGdoi
10.1177/1708538114550737subject
Has Abstractpub_date
2015-08-01 00:00:00pages
358-65issue
4eissn
1708-5381issn
1708-539Xpii
1708538114550737journal_volume
23pub_type
杂志文章相关文献
Vascular文献大全abstract::Popliteal artery aneurysms are relatively uncommon but potentially limb-threatening lesions that can thrombose or cause distal embolization. Identification of these aneurysms, especially in patients with abdominal aortic aneurysms, is imperative, and prophylactic treatment with either surgical exclusion and bypass or ...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2006.00049
更新日期:2006-09-01 00:00:00
abstract::Heparin is the predominant anticoagulant used in cardiac and vascular surgery. Heparin-induced thrombocytopenia (HIT) is one of the most serious and life-threatening adverse drug reactions associated with heparin use. In addition to the development of thrombocytopenia, HIT is associated with a high risk (40-50%) of th...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:
更新日期:2008-03-01 00:00:00
abstract::Carotid artery stenting (CAS) is a validated option in the treatment of selected extracranial carotid artery stenosis. Carotid artery dissection during CAS is a rare but potentially devastating complication. We report a case of acute dissection and thrombosis of the left internal carotid artery during filter tip wire ...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538113478774
更新日期:2013-08-01 00:00:00
abstract::Arterial pseudoaneurysms associated with osteochondromas are rare and most publications on this topic are case reports. The management of this double entity is not standardized. We wanted to update it. Literature searches on MEDLINE and EMBASE were performed using the keywords "artery pseudoaneurysm" and "osteochondro...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.1177/1708538116634532
更新日期:2016-12-01 00:00:00
abstract::Autogenous vein and arterial grafts, such as great saphenous veins and internal mammary and radial arteries, remain the gold standard conduits for vascular reconstruction. Expanded polytetrafluoroethylene (PTFE) grafts, which exhibit little inflammatory and thrombogenic reactivity, are the most commonly used material ...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2007.00053
更新日期:2007-11-01 00:00:00
abstract::Systemic anticoagulation with heparin or its unfractionated derivatives followed by warfarin therapy has been the mainstay of treatment in patients with lower extremity deep venous thrombosis (DVT). Although heparin is an effective treatment modality in preventing thrombus propagation, it provides minimal therapeutic ...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2007.00070
更新日期:2007-09-01 00:00:00
abstract::Commercially available aortic stent grafts differ in construction and clinical advantage such that creating hybrid endografts by combining components from different manufacturers is sometimes useful. We describe a multicenter experience using hybrid endografts to treat patients with challenging anatomy. Hospital recor...
journal_title:Vascular
pub_type: 杂志文章,多中心研究
doi:10.1258/rsmvasc.12.2.106
更新日期:2004-03-01 00:00:00
abstract::Objectives The relationship between preoperative medical consultations and postoperative complications has not been extensively studied. Thus, we investigated the impact of preoperative consultation on postoperative morbidity following elective abdominal aortic aneurysm repair. Methods A retrospective review was condu...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538116685946
更新日期:2017-08-01 00:00:00
abstract::An arterial pseudoaneurysm is a cavity which does not consist of three layers of arterial wall and is generally seen at femoral and radial artery sites due to bone fractures, arterial injuries and iatrogenic reasons such as catheterization. The treatment choice may be either surgical or conservative. Patients with pse...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1258/vasc.2010.cr0238
更新日期:2011-06-01 00:00:00
abstract::The increase in prevalence of certain cardiovascular risk factors increases susceptibility to vascular disease, which may create demand for surgical intervention. In our study, data collected by the American Association of Medical Colleges Physician Specialty Databook of 2012, the United States Census Bureau, and othe...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538115596652
更新日期:2016-08-01 00:00:00
abstract::Mycotic pseudoaneurysms of the peripheral arteries are rare and can occur as an extension of localized infection or from systemic sepsis. In some cases, no obvious source of infection may be identified. Both endovascular and open surgical management options are available for this important condition. We report a mycot...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2008.00060
更新日期:2009-05-01 00:00:00
abstract::Percutaneous transluminal angioplasty and stenting is being employed with increasing frequency for stenosis involving the brachiocephalic circulation. However, the efficacy of these procedures is limited by intimal hyperplasia and subsequent re-stenosis. Long-term results for treating lesions of the subclavian or inno...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538113478759
更新日期:2014-06-01 00:00:00
abstract::Several guidelines recommend carotid endarterectomy for patients with severe asymptomatic carotid stenosis to reduce the risk of a future cerebrovascular event, as long as the perioperative stroke/death rate is <3%. Based on improvements in best medical treatment, it was argued that currently best medical treatment al...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538114560463
更新日期:2015-02-01 00:00:00
abstract::Objectives Major and minor amputations are associated with significant rates of mortality. However, little is known about the impact of unplanned redo-amputation during the same hospitalization on outcomes. The objectives of this study were to identify the risk factors associated with in-hospital mortality after both ...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538117736677
更新日期:2018-06-01 00:00:00
abstract::Patients diagnosed with steal syndrome after hemodialysis access surgery have a few options for symptom relief while maintaining vascular access. These include fistula lengthening, banding, distal revascularization with interval ligation (DRIL), revision using distal inflow (RUDI) or proximalization of the arterial in...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2007.00047
更新日期:2007-07-01 00:00:00
abstract::May-Thurner syndrome is a rare clinical entity involving venous obstruction of the left lower extremity. Obstruction occurs secondary to compression of the left common iliac vein between the right common iliac artery and the underlying vertebral body. Current management largely involves endovascular therapy. A review ...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2009.00027
更新日期:2009-11-01 00:00:00
abstract::We evaluated the incidence, risk factors, and clinical consequences of renal microembolic events following endovascular aneurysm repair using suprarenal or infrarenal fixation. Pre- and postoperative (1 month) computed tomographic angiograms were reviewed for new renal perfusion defects. Suprarenal aortic and infraren...
journal_title:Vascular
pub_type: 杂志文章
doi:10.2310/6670.2007.00006
更新日期:2007-01-01 00:00:00
abstract::We present a 68-year-old female who developed multiple pseudo-aneurysms (PSAs) following cardiac catheterization via the right groin. During subsequent thrombin injection of PSAs, the patient developed acute occlusion of the popliteal artery. A covered stent was placed to obliterate the PSAs and allow for successful e...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538113499328
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:Carotid stenosis with crescendo-transient-ischemic-attack (cTIA) requires a prompt intervention to reduce the stroke risk. Few data are reported in literature about cTIA suggesting a different perioperative risk compared with patients with single TIA (sTIA). This study aimed to compare the outcome of carotid ...
journal_title:Vascular
pub_type: 杂志文章,多中心研究
doi:10.1177/1708538118799225
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to investigate the durability and clinical efficacy of profundoplasty as a sole procedure in patients presenting with critical limb ischaemia associated with profunda femoral artery disease and superficial femoral artery occlusion. METHODS:Retrospective analysis of outcomes from all...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538120963901
更新日期:2020-10-14 00:00:00
abstract::Objective This study evaluated the concept of percutaneous closure of insufficient veins using the VeinScrew principle. Methods The VeinScrew is designed to place a spring-shaped implant that contracts and clamps around the vein. The ability of the device to occlude adequately was tested in a bench model experiment. T...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538116644117
更新日期:2017-02-01 00:00:00
abstract::This present study investigated the influence of combined preoperative clopidogrel and aspirin (ASA) administration on adverse postoperative outcomes and bleeding risk in patients undergoing carotid endarterectomy (CEA). A retrospective cohort study of all consecutive patients undergoing isolated CEA (n = 1488) betwee...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538113478763
更新日期:2013-08-01 00:00:00
abstract::Objectives There is paucity of information regarding critical limb ischemia-related readmission rates in patients admitted with critical limb ischemia. We studied 30-day critical limb ischemia-related readmission rate, its predictors, and clinical outcomes using a nationwide real-world dataset. Methods We did a second...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538117727955
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Centralisation of vascular surgery services has coincided with a move towards endovascular repair of ruptured abdominal aortic aneurysms with the goal to improve patient outcomes. The aim of this study was to assess the effect of rural presentation and transfer times on survival from ruptured abdominal aorti...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538115599315
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Aneurysms associated with human immunodeficiency virus (HIV) are pseudo-aneurysms and the pathology is unique to HIV vasculopathy. We report outcomes of endovascular therapy for HIV iliac artery aneurysms in a series of patients to augment the sparse literature on these aneurysms. METHODS:The records from Ja...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538114560457
更新日期:2015-12-01 00:00:00
abstract::Objectives Treatment options for venous insufficiency are rapidly evolving in the office setting and include venography, intravascular ultrasound, and venous stenting. Non-thrombotic iliac vein lesions assessment and treatment in an office setting is currently an area of interest. The purpose of this study is to demon...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538117721624
更新日期:2018-02-01 00:00:00
abstract::In the past decade, carbon monoxide has lost its reputation as a toxic gas and has gained a following of scientists who now appreciate its potential therapeutic utility as an anti-inflammatory and cytoprotective agent. Its vasoprotective properties have also gained a tremendous amount of attention, especially its abil...
journal_title:Vascular
pub_type: 杂志文章,评审
doi:10.2310/6670.2008.00090
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Preoperative consultation is usually not performed before insertion of a totally implantable venous access device (TIVAD). In our experience, an incomplete preoperative assessment, a predictable medical condition contraindicating surgery, or no-show patients the day of surgery led to several surgery cancella...
journal_title:Vascular
pub_type: 杂志文章
doi:10.1177/1708538120930470
更新日期:2020-12-01 00:00:00
abstract::Proteomics is evolving as an important research technique in cardiovascular disease. We present exploratory research for a systemic biomarker of abdominal aortic aneurysm (AAA) in serum. Forty patients, 20 with large AAAs and 20 matched controls, were prospectively recruited. Serum was harvested, enriched, and mined f...
journal_title:Vascular
pub_type: 杂志文章
doi:10.2310/6670.2010.00046
更新日期:2010-09-01 00:00:00
abstract::Hypothenar hammer syndrome (HHS) is a rather rare condition and is a term used to describe an aneurysm or thrombosis of the ulnar artery. It is considered an occupational or recreational injury and is usually a result of a repetitive trauma to the hypothenar region where the unique anatomy of the Guyon canal allows ar...
journal_title:Vascular
pub_type: 杂志文章
doi:10.2310/6670.2008.00002
更新日期:2008-09-01 00:00:00