Abstract：
AIM:To assess efficacy and safety of selective beta-adrenoblockers (BAB) metoprolol succinate and nebivolol in patients with arterial hypertension (AH) and/or IHD associated with bronchoobstructive syndrome (BOS). MATERIAL AND METHODS:Fifty patients suffering from AH and/or IHD associated with BOS in chronic obstructive pulmonary disease (COPD) and/or bronchial asthma (BA) of any severity in remission received BAB. Safety of BAB was evaluated by dynamics of respiratory symptoms and bronchial patency. An antihypertensive effect of BAB was assessed by the data of 24-h monitoring of BP, an antianginal one--by dynamics of clinical symptoms, amount of nitrates taken and exercise tolerance (6-min walk). The results of Holter ECG monitoring and an antiarrhythmic effect of BAB were also studied. RESULTS; Metoprolol succinate and nebivolol did not deteriorate bronchial patency (baseline FEV1--81.08 +/- 22.57%, at the end of the study--84.58 +/- 23.72% and 71.12 +/- 19.95, 73.19 +/- 21.70, respectively) in COPD and/or BA. Both drugs showed high antihypertensive efficacy as monotherapy and in combined therapy. Anginal attacks severity and frequency reduced significantly. The need in nitrosorbide fell noticeably, exercise tolerance increased significantly. Metoprolol succinate and nebivolol have a good anti-arrythmic effect. CONCLUSION:Metoprolol succinate and nebivolol are safe in patients with bronchoobstructive syndrome and AH and/or IHD in the presence of cardiovascular indications; these drugs can be used in patients with severe COPD and BA as well as their exacerbations unrelated to administration of beta-adrenoblocker.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Ovcharenko SI,Litvinova IV,Mikolkin VIsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
12-8issue
9eissn
0040-3660issn
2309-5342journal_volume
79pub_type
杂志文章abstract：AIM:To compare efficacy and tolerability of combined therapy with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) with MTX-monotherapy in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:RA patients (n = 60) who had not been treated with the above drugs were randomized (1:1) to receiv...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-01-01 00:00:00
abstract：:Results of clinical, psychological and psychophysiological examinations of 136 patients with mild essential hypertension indicate that psychorelaxation therapy is more effective in patients with a higher level of BP response to emotional stress and a shorter period of BP recovery after stress. Those patients had a mod...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：AIM:To present systemic vasculitis (SV) diagnostic stages. SUBJECTS AND METHODS:Immunological and hemostatic parameters were determined, vascular scanning, histological and immunomorphological studies were performed in 360 patients. RESULTS:The main diagnostic searching stages were presented, which could reveal the k...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Diphtheria morbidity among adult population of Moscow is growing. The tests of different modes and schemes of heterogeneous antidiphtheria serum administration have found out that the highest efficacy of serotherapy was achieved with a single intravenous dose. Another treatment of diphtheria is hemosorption. Widely us...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The paper discusses current approaches to diagnosing in an internal medicine clinic and to improving diagnostic tactics. It gives prospects for training physicians in current diagnostic approaches in the framework of the continuing medical education system. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:The results of intracoronary thrombolytic therapy with avelysine given to 21 patients with acute myocardial infarction are described. Intracoronary thrombolysis was performed on the average 5 h and 30 min after myocardial infarction onset. Recanalization of the coronary artery was attained in 16 patients, with no leth...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:At present, compelling evidence has been obtained that combined therapy of pulmonary arterial hypertension (PAH) with specific drugs can significantly slow progression of PAH. Therefore, in current guidelines combination therapy is already considered as standard treatment for a significant proportion of patients with ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.26442/terarkh201890372-80
更新日期：2018-04-19 00:00:00
abstract：:The authors provide data obtained during echocardiographic examination of 16 patients with different patterns of alcoholic heart injury primarily at the early stages of alcoholism. The group of patients without heart rhythm abnormality showed a decrease in myocardial contractile function, moderate dilatation of the le...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：AIM:To evaluate the anti-ischemic and anti-anginal efficacy of meldonium (Idrinol) in its short-term use as part of combination therapy in patients with chronic heart failure in the early post-infarction period. SUBJECTS AND METHODS:The investigation enrolled 60 patients (men and women) aged 45 to 75 years at weeks 3-...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-01-01 00:00:00
abstract：:Altogether 29 patients (14 with a characteristic clinical picture of CHD, 6 with probable angina and 9 with nonischemic cardialgia) were investigated by methods of two-dimensional echocardiography (echoCG) at rest and in combination with isometric exercise and left atrial transesophageal pacing test (LATPT) as well as...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A study was made of exercise tolerance and indices of central hemodynamics in 151 patients with "isolated" angina and its combination with cardialgia, arterial hypertension and postinfarctional cardiosclerosis. Daily attacks of angina of effort (III functional class) were noted in all the patients. In patients with "i...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：AIM:To evaluate the presence and the severity of the complaints (headache, dizziness, memory loss, concentration of attention, sleep disturbances, decreased mood, increased anxiety), the state of cognitive functions, emotional status and quality of night sleep in treatment-naïve middle-aged patients with mild to modera...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/terarkh201890915-26
更新日期：2018-09-20 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The content of steroid hormone receptors was measured in 22 men with mammary gland carcinoma. The content of estrogen receptors appeared high in both primary tumor and cancer metastasis. It was not dependent on the process extent or patients' age. In some cases the tumor remained "receptor-positive" after preoperative...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The content of IgA, IgM, IgG and IgE was measured in 55 male patients with uncomplicated essential hypertension (EH) running a labile course (25 patients) and a stable course (30 patients). Analyzing the material, account was taken of aggravated heredity factor as regards arterial hypertension, established according t...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：AIM:To evaluate the effect of sitagliptin in combination with metformin on glucose toxicity and lipotoxicity in patients with type 2 diabetes mellitus. SUBJECTS AND METHODS:. Eighty-two overweight and dyslipidemic patients (mean age 55.3 +/- 9.1 years) who had not achieved the goal levels of glycated hemoglobin (HbA1c...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-01-01 00:00:00
abstract：:Sedacorone (amiodarone) was given to 70 outpatients with coronary heart disease for 1.5-2 years to prevent paroxysms of cardiac arrhythmia after recovery of sinus rhythm. Sedacorone was administered initially in the dose 600 mg/day for 10-12 days, then the dose lowering was adjusted to the tolerance, heart rate and EC...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：AIM:To ascertain a relationship between cholesterol content in circulating immune complexes (CIC) and plasm lipid peroxidation (LPO) in patients with ischemic heart disease (IHD). MATERIALS AND METHODS:Blood samples from 33 IHD patients 23 of which had a history of myocardial infarction and from 8 healthy subjects wer...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:As many as 283 drivers with a history of acute myocardial infarction were examined. In the long-term postinfarction period, the number of the able-bodied accounted for 22.8%, the number of persons with restricted work fitness was 43.3%, that of the disabled amounted to 33.9%. It should be noted that about 60% of the a...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：AIM:To ascertain criteria of aggressive course of juvenile rheumatoid arthritis (JRA) during 6-12 months since the disease onset, to measure the rate of destruction progression, to formulate indications for conduction of early immunosuppressive therapy. MATERIALS AND METHODS:The study included 30 patients (21 girls an...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The state of the renin-angiotensin system (RAS) was studied in 102 patients with chronic glomerulonephritis with the nephrotic syndrome (NS) with relation to a phase of the edematous syndrome and sodium balance. Heterogeneity of patients with NS was shown with regard to RAS activity and the circulating blood volume in...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The effect of the plasma obtained before and after graded submaximal exercise was examined in 10 bronchial asthma patients with the syndrome of asthma of physical effort (APE) by means of fluorescent exploration using the cation probe 4-(p-demethylaminostyryl)-1-methylpyridinum and rat thymocytes as a test system. Fou...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:As many as 30 patients suffering from systemic lupus erythematosus (SLE) with the clinical signs of central nervous system derangement were examined. The mean age of the patients was 31.1 years. Using EIA, antibodies against cardiolipin (a-CL) were detected in 21 patients (70%). A-CL were revealed in all the patients ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Neurological complications were examined in 30 patients with multiple myeloma. The neurological syndromes which play the key role in the clinical picture of the disease were distinguished. The pathogenetic mechanisms of the development of the individual symptoms and the methods for their treatment are discussed. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Peripheral blood erythrocytes of patients with bronchial asthma (BA) and preasthma (PA) were investigated using the following methods: 1) the radiochemical method--the level of specific binding of beta-adrenergic ligands; 2) direct erythrocytometry--erythrocyte diameter; 3) the cytochemical method (paraldehyde fuchsin...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The paper is concerned with 10 cases of multiple myeloma with myeloid (myeloma-myeloid) splenomegaly and myelemia; 4 cases of chronic subleukemic (or aleukemic) lymphocyte plasma cell leukemia with paraproteinemia G which do not differ in the clinical or morphological picture from Waldenström's macroglobulinemia ("Wal...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：AIM:to assess the long-term angiographic and clinical results of percutaneous coronary interventions (PCI) with implantation of the drug-eluting stent (DES) Apollo in patients with stable angina pectoris. SUBJECTS AND METHODS:The study enrolled 48 patients with stable angina who had been implanted with 59 stents. A fo...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2010-01-01 00:00:00
