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On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents.

Abstract：

:ATP-dependent Ca2+ sequestration by rat liver microsomes was assayed using three different methods, and characterized with regard to the effect of various inhibitors. When glucose and hexokinase were added in combination to deplete ATP in the incubation, Ca2+ uptake was followed by rapid release of Ca2+ from the microsomes. Ca2+ sequestration was inhibited by reagents that cause alkylation (e.g. p-chloromercuribenzoate) or oxidation (e.g. diamide) of protein sulfhydryl groups. Moreover, pretreatment of the microsomes with cystamine, which causes formation of mixed disulfides with protein thiols, also resulted in the inhibition of Ca2+ sequestration. It is concluded that microsomal Ca2+ sequestration is critically dependent on protein sulfhydryl groups, and that modification of protein thiols may be an important mechanism for the inhibition of microsomal Ca2+ sequestration by a variety of toxic agents.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Thor H,Hartzell P,Svensson SA,Orrenius S,Mirabelli F,Marinoni V,Bellomo G

doi

10.1016/0006-2952(85)90236-9

subject

Has Abstract

pub_date

1985-10-15 00:00:00

pages

3717-23

issue

20

eissn

0006-2952

issn

1873-2968

pii

0006-2952(85)90236-9

journal_volume

34

pub_type

杂志文章

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