Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction.

Abstract:

OBJECTIVES:The aim of this work was to investigate the immunohistochemical expression of nestin, a member of the intermediate filament family, in adenohypophysial vasculature during development and progression of pituitary infarction. METHODS:Forty-five nontumorous adenohypophyses and 34 pituitary adenomas of various types, all exhibiting acute or healing infarcts, were examined immunohistochemically using the streptavidin-biotin-peroxidase complex method. RESULTS:In both adenohypophyses and pituitary adenomas without infarction, nestin was expressed in only a few capillaries and endothelial cells. In acute infarcts without a vascular response, no nestin was demonstrable within necrotic capillaries (50 cases). In organizing infarcts, newly formed vessels spreading into necrotic zones showed nestin expression in all capillaries and practically every endothelial cell (25 cases). In the hypocellular, fibrotic scar phase, only a few vessels (4) were apparent, and immunoreactivity was focal and mild. CONCLUSIONS:Nestin is strongly expressed in newly formed capillaries and is downregulated when infarcts transform to fibrous tissue. Nestin expression may provide valuable insight into the process of pituitary angiogenesis.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Salehi F,Kovacs K,Cusimano MD,Horvath E,Bell CD,Rotondo F,Scheithauer BW

doi

10.3171/JNS/2008/108/01/0118

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

118-23

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

108

pub_type

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