Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.

Abstract:

:The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Rennert RC,Hoshide RR,Signorelli JW,Amaro D,Sack JA,Brennan CW,Chen CC

doi

10.3171/2016.4.JNS153052

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

1472-1478

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

126

pub_type

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