Long-term intraventricular baclofen infusion in beagles.

Abstract:

OBJECT:This study was designed to evaluate the clinical and histopathological effects of long-term (3-month) intraventricular baclofen (IVB) infusion in beagle dogs. METHODS:Catheters were inserted stereotactically into the lateral ventricles of nine dogs and were connected to implanted Synchromed II pumps. Saline solution (control animals) and IVB (experimental animals) were infused continuously. The IVB dosages ranged from 100 to 1000 microg/day. RESULTS:An IVB infusion of 135 microg/day or less throughout a 3-month period was associated with no adverse side effects in any animal. Infusion of 150 microg/day produced overt seizures in one dog and produced adverse side effects in another; a reduction in the dosage given to these animals to 135 microg/day was tolerated with no adverse effects. Infusion of IVB at a dosage of 250, 500, or 1000 microg/day caused lethal toxicity within the first 4 days of infusion. Histopathological specimens obtained at necropsy revealed no ventricular or subependymal changes in animals receiving an IVB dosage of 135 microg/day or less. CONCLUSIONS:Intraventricular baclofen infusion in beagles has dose-related toxicity; however, no clinical or neurological toxicity was evidenced at clinically tolerated dosages (< or =135 microg/day) throughout 3 months of infusion.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Albright AL

doi

10.3171/PED-07/09/225

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

225-7

issue

3 Suppl

eissn

0022-3085

issn

1933-0693

journal_volume

107

pub_type

杂志文章
  • Hemorrhage risk of cerebral dural arteriovenous fistulas following Gamma Knife radiosurgery in a multicenter international consortium.

    abstract:OBJECTIVE:The authors performed a study to evaluate the hemorrhagic rates of cerebral dural arteriovenous fistulas (dAVFs) and the risk factors of hemorrhage following Gamma Knife radiosurgery (GKRS). METHODS:Data from a cohort of patients undergoing GKRS for cerebral dAVFs were compiled from the International Radiosu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.12.JNS182208

    authors: Starke RM,McCarthy DJ,Chen CJ,Kano H,McShane BJ,Lee J,Patibandla MR,Mathieu D,Vasas LT,Kaufmann AM,Wang WG,Grills IS,Cifarelli CP,Paisan G,Vargo J,Chytka T,Janouskova L,Feliciano CE,Sujijantarat N,Matouk C,Chiang

    更新日期:2019-03-15 00:00:00

  • Variations of the extreme-lateral craniocervical approach: anatomical study and clinical analysis of 69 patients.

    abstract:OBJECT:The aim of this study was to describe six variations of the extreme-lateral craniocervical approach, their application, and treatment results. METHODS:During a 4-year period 69 patients underwent surgery in which six variations of the extreme-lateral craniocervical approach were performed. The variations includ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.1999.90.2.0206

    authors: Salas E,Sekhar LN,Ziyal IM,Caputy AJ,Wright DC

    更新日期:1999-04-01 00:00:00

  • The use of clip-suture in thoracic sympathectomy. Technical note.

    abstract::A technique is described for using a clip-suture to expedite handling of the divided sympathetic chain in a deep, small upper-thoracic exposure. No late failures were experienced in 23 patients with hyperhydrosis surgically treated using this technique. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.3.0482

    authors: Beatty RA

    更新日期:1994-09-01 00:00:00

  • Anatomic variations of venous sinuses in the region of the torcular Herophili.

    abstract::In this study of 110 cranial cavities from adult cadavers, the superior sagittal sinus was found to divide into two channels. In most cases, the division was associated with a dural partition. Essentially, the variations as observed in this study could be grouped into three types: Type 1 includes those specimens in wh...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.1.0090

    authors: Bisaria KK

    更新日期:1985-01-01 00:00:00

  • Observations on the blood and perineurial permeability barriers of surviving nerve allografts in immunodeficient and immunosuppressed rats.

    abstract::The authors investigate whether there are any permeability changes in the endoneurial blood-nerve barrier and the perineurium-nerve barrier of surviving nerve allografts. In a normal nerve, the blood-nerve barrier regulates the passage of substances from endoneurial blood vessels into the endoneurium, whereas the peri...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.78.5.0794

    authors: Zalewski AA,Kadota Y,Azzam NA,Azzam RN

    更新日期:1993-05-01 00:00:00

  • Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance.

    abstract:OBJECT:Several methods are used for stereotactically guided implantation of electrodes into the subthalamic nucleus (STN) for continuous high-frequency stimulation in the treatment of Parkinson's disease (PD). The authors present a stereotactic magnetic resonance (MR) method relying on three-dimensional (3D) T1-weighte...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.4.0615

    authors: Bejjani BP,Dormont D,Pidoux B,Yelnik J,Damier P,Arnulf I,Bonnet AM,Marsault C,Agid Y,Philippon J,Cornu P

    更新日期:2000-04-01 00:00:00

  • Destructive procedures for control of cancer pain: the case for cordotomy.

    abstract:OBJECT:Historically, destructive procedures for cancer pain were the main line of treatment therapy. However, the use of high-dose opioids has essentially replaced such procedures. Recognition of the limits of medical therapy to treat cancer pain effectively is growing, while conversely, in regions with limited access ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2010.6.JNS10119

    authors: Raslan AM,Cetas JS,McCartney S,Burchiel KJ

    更新日期:2011-01-01 00:00:00

  • Middle cerebral artery branch occlusion mimicking a saccular aneurysm on 3D digital subtraction angiography.

    abstract::The angiographic appearance of an intracranial arterial occlusion is typically distinct from that of a saccular aneurysm, with only a few reported cases of occlusion simulating aneurysm. At the same time, a small percentage of symptomatic intracranial aneurysms present with a stroke. Accurate diagnosis of these condit...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS.2008.109.12.1123

    authors: Pearl MS,Tamargo R,Gailloud P

    更新日期:2008-12-01 00:00:00

  • Significance of postshunt ventricular asymmetries.

    abstract::Ventricular asymmetries after shunt surgery were studied. Right and left ventricular areas from pre-and postoperative computerized tomography scans were measured with a computer digitizing technique, and the respective areas were expressed as a ratio. Measurements were made from the scans of 15 hydrocephalic children ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.55.2.0183

    authors: Linder M,Diehl JT,Sklar FH

    更新日期:1981-08-01 00:00:00

  • Surgical anatomy of the juxta-dural ring area.

    abstract:OBJECT:The authors report on the surgical anatomy of the juxta-dural ring area of the internal carotid artery to add to the information available about this important structure. METHODS:Twenty sides of cadaver specimens were used in this study. The plane of the dural ring was found to incline in the posteromedial dire...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.2.0250

    authors: Oikawa S,Kyoshima K,Kobayashi S

    更新日期:1998-08-01 00:00:00

  • Endovascular treatment of intracranial aneurysms: comparative evaluation in a terminal bifurcation aneurysm model in dogs.

    abstract:OBJECT:The authors investigated whether HydroCoils decreased coil compaction and aneurysm recanalization in a canine model of a large, wide-necked, high-flow bifurcation aneurysm. METHODS:Eleven experimental aneurysms were created. Two aneurysms were untreated (Group 1); three were treated with standard platinum coils...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.6.0996

    authors: Yoshino Y,Niimi Y,Song JK,Silane M,Berenstein A

    更新日期:2004-12-01 00:00:00

  • Cognitive functioning early after surgery of gliomas in eloquent areas.

    abstract:OBJECT:Patients with gliomas frequently have cognitive deficits, and surgery can exacerbate these deficits. Preoperative assessment is therefore crucial in patients undergoing surgery for glioma in eloquent areas, because the proximity of functional areas increases the risk of permanent postoperative cognitive disturba...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.JNS12263

    authors: Satoer D,Vork J,Visch-Brink E,Smits M,Dirven C,Vincent A

    更新日期:2012-11-01 00:00:00

  • Extended endoscopic endonasal approach for selected pituitary adenomas: early experience.

    abstract:OBJECT:Whereas most pituitary adenomas are removable via the transsphenoidal approach, certain cases, such as dumbbell-shaped or suprasellar adenomas and recurrent and/or fibrous tumors, remain difficult to treat. The authors present their experience with the extended endoscopic endonasal approach to the suprasellar ar...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.9.JNS10262

    authors: Di Maio S,Cavallo LM,Esposito F,Stagno V,Corriero OV,Cappabianca P

    更新日期:2011-02-01 00:00:00

  • Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.

    abstract:OBJECT:Endothelial tight junction (TJ) expression is mostly absent in cerebral cavernous malformations (CMs), which causes increased perilesional erythrocyte and fluid oozing. However, in a subset of CM lesions, foci of preserved TJ staining are observed along endothelial cell contacts. The clinical relevance of this f...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.6.JNS132775

    authors: Jakimovski D,Schneider H,Frei K,Kennes LN,Bertalanffy H

    更新日期:2014-09-01 00:00:00

  • Connectivity of the frontal and anterior insular network: a cortico-cortical evoked potential study.

    abstract::OBJECT The frontal and insular fiber network in humans remains largely unknown. This study investigated the connectivity of the frontal and anterior insular network in humans using cortico-cortical evoked potential (CCEP). METHODS This retrospective analysis included 18 patients with medically intractable focal epilep...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.6.JNS15622

    authors: Enatsu R,Gonzalez-Martinez J,Bulacio J,Mosher JC,Burgess RC,Najm I,Nair DR

    更新日期:2016-07-01 00:00:00

  • Carotid artery end-to-end anastomosis in the rat using the argon laser.

    abstract::Microvascular end-to-end anastomoses of rat common carotid arteries measuring 0.6 to 0.7 mm in diameter were performed using an argon surgical laser system. Vascular bonding with the argon laser was accomplished in all cases. The anastomosed carotid artery segments were evaluated both angiographically and histological...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.5.0771

    authors: Pribil S,Powers SK

    更新日期:1985-11-01 00:00:00

  • Neurocognitive changes in pituitary adenoma patients after Gamma Knife radiosurgery.

    abstract::OBJECTIVEPituitary adenomas and the treatment required for the underlying neuropathology have frequently been associated with cognitive dysfunction. However, the mechanisms for these impairments remain the subject of much debate. The authors evaluated cognitive outcomes in patients treated with or without Gamma Knife ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.7.GKS181595

    authors: Tooze A,Sheehan JP

    更新日期:2018-12-01 00:00:00

  • Efficacy of chymopapain chemonucleolysis. A long-term review of 105 patients.

    abstract::A 9- to 12-year follow-up review was conducted in 105 of 124 patients who were treated with chymopapain chemonucleolysis for herniated lumbar disc. The data were obtained from responses to a questionnaire. Seventy-nine patients (75.2%) reported marked improvement, six (5.7%) had slight improvement, and 20 (19.0%) had ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.5.0662

    authors: Javid MJ

    更新日期:1985-05-01 00:00:00

  • Classification and regression trees (CART) for prediction of function at 1 year following head trauma.

    abstract::A cohort of 514 hospitalized head-injury survivors was identified based on their injury and 448 (87%) of them were followed for 1 year. Comprehensive neurobehavioral testing was performed 1 month and 1 year after injury. The authors developed predictions of six neuropsychological and two psychosocial outcomes 1 year a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.5.0764

    authors: Temkin NR,Holubkov R,Machamer JE,Winn HR,Dikmen SS

    更新日期:1995-05-01 00:00:00

  • A new approach to the surgical treatment of lumbar spondylosis.

    abstract::The authors discuss routine removal of inferior articular processes and their facets during laminectomy, with wide visualization of the lumbar nerve roots, which has proven to be most successful in relief of the symptoms of lumbar spondylosis. No instance of postoperative vertebral instability has been found. In a con...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.2.0148

    authors: Shenkin HA,Hash CJ

    更新日期:1976-02-01 00:00:00

  • Deep brain stimulation for treatment of hemichorea-hemiballism after craniopharyngioma resection: long-term follow-up.

    abstract::Hemichorea-hemiballism is a rare movement disorder that has various causes. In treatment-resistant cases, both thalamic and pallidal functional procedures have been shown to yield beneficial results. Until now it has not been clarified whether the thalamus or the pallidum would yield a superior outcome. After resect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.6.JNS101388

    authors: Capelle HH,Kinfe TM,Krauss JK

    更新日期:2011-11-01 00:00:00

  • Intracranial neurothekeoma (nerve-sheath myxoma). Case report.

    abstract::Neurothekeoma is a benign cutaneous nerve-sheath tumor. The authors describe the case of a 16-year-old girl with a parasellar neurothekeoma that was successfully removed. Magnetic resonance imaging with gadolinium administration revealed bright enhancement of the peripheral portions and nonhomogeneous uptake in the ce...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.2.0280

    authors: Paulus W,Warmuth-Metz M,Sörensen N

    更新日期:1993-08-01 00:00:00

  • Predictive value of positive high-sensitivity troponin T in intubated traumatic brain injury patients.

    abstract::OBJECTIVEThe clinical relevance of high-sensitivity troponin T (HsTnT) in trauma patients is not well explored. In this study, the authors aimed to study the predictive value of serum HsTnT in intubated patients who had sustained traumatic brain injury (TBI).METHODSA retrospective analysis was conducted for all intuba...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.7.JNS17675

    authors: El-Menyar A,Asim M,Latifi R,Bangdiwala SI,Al-Thani H

    更新日期:2018-12-01 00:00:00

  • Vestibular schwannoma surgery in the elderly: a matched cohort study.

    abstract:OBJECT:The authors' objective was 2-fold: 1) to compare outcomes of microsurgical resection for vestibular schwannoma (VS) between patients aged 70 years or older and patients younger than 70 years and 2) to test the hypothesis that symptomatic tumors in elderly patients represent a more aggressive variant of VS than t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.6.JNS122433

    authors: Van Abel KM,Carlson ML,Driscoll CL,Neff BA,Link MJ

    更新日期:2014-01-01 00:00:00

  • Pineal region giant cell astrocytoma associated with tuberous sclerosis: case report.

    abstract::Tuberous sclerosis complex is a genetic disorder characterized by the development of hamartomas in multiple organs including the brain, skin, eye, kidney, and heart. Neurological features include seizures and mental retardation. Cortical tubers and subependymal nodules are the characteristic intracranial lesions of tu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2005.102.3.0322

    authors: Dashti SR,Robinson S,Rodgers M,Cohen AR

    更新日期:2005-04-01 00:00:00

  • Desmoid-type fibromatoses involving the brachial plexus: treatment options and assessment of c-KIT mutational status.

    abstract:OBJECT:Desmoid-type fibromatoses are a locally invasive soft-tissue lesion that is most commonly encountered in abdominal sites. The tumor also affects head and neck areas, particularly the supraclavicular region, where it may encase and distort the brachial plexus and compromise neurovascular structures. Neurosurgeons...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.5.749

    authors: Seinfeld J,Kleinschmidt-Demasters BK,Tayal S,Lillehei KO

    更新日期:2006-05-01 00:00:00

  • Lymphomatoid granulomatosis apparently confined to one temporal lobe. Case report.

    abstract::Lymphomatoid granulomatosis is of uncertain etiology and poses problems with diagnosis and treatment. A case with involvement of the right temporal lobe, but associated with cystoid macular edema of the retina, is described. The unusual mode of presentation, the radiographic, operative, and pathological findings, the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.4.0612

    authors: Kerr RS,Hughes JT,Blamires T,Teddy PJ

    更新日期:1987-10-01 00:00:00

  • Persistent high lactate level as a sensitive MR spectroscopy indicator of completed infarction.

    abstract::Serial proton (1H) and phosphorus-31 (31P) magnetic resonance (MR) spectroscopy of cerebral infarction was performed in rats to assess the sensitivity of these techniques for use in clinical cerebral infarction. In this experimental chronic infarction model, 31P spectroscopy tended to return to a "normal" pattern with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.72.5.0763

    authors: Houkin K,Kwee IL,Nakada T

    更新日期:1990-05-01 00:00:00

  • Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines.

    abstract:OBJECT:Galectin-1 is highly expressed in motile cell lines. The authors investigated whether galectin-1 actually modulates the migration and invasion of human glioblastoma multiforme (GBM) cell lines, and whether its expression with respect to invasion and prognosis is attributable to certain glioma subgroups. METHODS...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/8/0273

    authors: Jung TY,Jung S,Ryu HH,Jeong YI,Jin YH,Jin SG,Kim IY,Kang SS,Kim HS

    更新日期:2008-08-01 00:00:00

  • Disc herniation at T1-2. Report of four cases and literature review.

    abstract::In preparing this paper, the authors reviewed their experiences with four cases of T1-2 disc herniation as well as the medical literature on the subject. Intervertebral thoracic disc herniations are uncommon and high thoracic disc herniations are rare. In the upper third of the thoracic spine, T1-2 is the most common ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1998.88.1.0148

    authors: Morgan H,Abood C

    更新日期:1998-01-01 00:00:00