Abstract:
:Intravesical BCG (bacillus Calmette-Guérin) instillation is a first-line treatment for superficial transitional cell carcinoma of the bladder. A rare but severe complication of BCG immunotherapy is the development of disseminated BCG disease, which can result in miliary pneumonitis, granulomatous hepatitis, soft tissue infections, bone marrow involvement, and sepsis. Symptoms can present as early as a few hours or as late as several months following the BCG therapy. The key finding in disseminated BCG disease is the formation of caseating granulomas in distant organs; detection of BCG organisms from tissue samples can be difficult. Recommended treatment for disseminated BCG disease includes a combination of antituberculous medications (with the exception of pyrazinamide, to which BCG is typically resistant) and a tapering course of steroids. We present the cases of four patients who developed granulomatous infection consistent with disseminated disease after intravesical BCG treatment and provide a summary of current clinical management recommendations.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Nadasy KA,Patel RS,Emmett M,Murillo RA,Tribble MA,Black RD,Sutker WLdoi
10.1097/SMJ.0b013e31815d4047subject
Has Abstractpub_date
2008-01-01 00:00:00pages
91-5issue
1eissn
0038-4348issn
1541-8243pii
00007611-200801000-00029journal_volume
101pub_type
杂志文章abstract::Of ten patients with anterior diaphragmatic hernia treated by operation, only three had shortness of breath and chest pain. The remainder of the patients were referred to us because of a roentgenographic abnormality. All patients have had follow-up of between six months and 11 years without recurrence. Surgical repair...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198203000-00008
更新日期:1982-03-01 00:00:00
abstract:OBJECTIVE:To compare mobile health (mHealth) usage by residents of West Virginia with national estimates. METHODS:Pew Research Center data from its Internet and American Life Project were accessed for secondary data analysis. These data, available to the public, are a probability sample of Internet use in the United S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000879
更新日期:2018-10-01 00:00:00
abstract::Hearing and/or balance disorders are symptoms that may be associated with tumors of the cerebellopontine angle (CPA). Between March 1988 and May 1995, 22 patients had diagnosis or evaluation of CPA tumors at Cleveland Clinic Florida. The most common presenting signs or symptoms included unilateral low-frequency tinnit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199705000-00010
更新日期:1997-05-01 00:00:00
abstract::The use of psychotropic medication is often associated with weight gain. We provide documentation for this effect and review the mechanisms possibly responsible for it in the case of neuroleptic agents, lithium carbonate, monoamine oxidase inhibitors, and amitriptyline. We also enumerate the undesirable medical conseq...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198311000-00021
更新日期:1983-11-01 00:00:00
abstract::Pressure modes of invasive mechanical ventilation generate a tidal breath by delivering pressure over time. Pressure control ventilation (PC) is the prototypical pressure mode and is patient- or time-triggered, pressure-limited, and time-cycled. Other pressure modes include pressure support ventilation (PSV), pressure...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e31822da7fa
更新日期:2011-10-01 00:00:00
abstract::A 66-year-old woman with a subacute onset of mild dementia and headaches was discovered to have multiple large, hyperdense lesions on cranial CT scan. Biopsy showed poorly differentiated adenocarcinoma with necrosis and dystrophic calcification, which represented an unusual initial manifestation of metastatic breast c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198602000-00030
更新日期:1986-02-01 00:00:00
abstract::Presented in a case in which calcification of the adrenal gland was roentgenographically evident on the first day of life. The earliest previously reported case of adrenal calcification was at 8 days of age and was attributed to an intrapartum hemorrhage. It is proposed that an intrauterine third trimester insult was ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197903000-00045
更新日期:1979-03-01 00:00:00
abstract::We describe a patient with pseudotumor cerebri for which a lumboperitoneal (LP) shunt was placed. After a pseudomeningocele was noted at the lumbar incision site, an LP shunt revision was done, at which time migration of the catheter into the thecal sac was noted. Three months later, radiologic studies revealed crania...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199606000-00019
更新日期:1996-06-01 00:00:00
abstract::A case of nephrotic syndrome due to minimal change renal disease was associated with minimally symptomatic nodular sclerosing Hodgkin's disease in a 15-year-old girl. Although minimal renal disease is the most frequently described biopsy finding in this paraneoplastic syndrome, the combination of nodular sclerosing Ho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00027
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVES:Endothelial dysfunction (ED) has been reported in patients with autosomal-dominant polycystic kidney disease (ADPKD). Coronary flow velocity reserve (CFVR) is a noninvasive test showing endothelial function of epicardial coronary arteries and coronary microcirculatory function. The aim of this study was to i...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181d80cae
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:The US Bureau of Primary Health Care has promoted collaboration between federally funded community health centers and neighborhood religious congregations, yet little is known about how such organizations currently interact in underserved neighborhoods. METHODS:Semistructured interviews were conducted with l...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000168338.87518.cc
更新日期:2005-12-01 00:00:00
abstract::A 64-year-old woman had the syndrome of inappropriate ADH secretion (SIADH) after surgical repair of a ruptured aneurysm of the anterior communicating artery. SIADH began while the intracranial pressure was elevated, and resolved when the pressure returned to normal. Whether this syndrome was caused by direct hypothal...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00030
更新日期:1980-07-01 00:00:00
abstract::Phenytoin has traditionally been used for both prophylaxis and acute treatment of alcohol withdrawal seizures. With the exception of a well defined subgroup of withdrawing patients, this may not be appropriate. Chronic anticonvulsant therapy is not indicated without evidence of another underlying seizure diathesis. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197809000-00015
更新日期:1978-09-01 00:00:00
abstract::To understand fully a physician's role in society, and to deal successfully with the current sense of crisis, the medical profession must evolve a world-view that appropriately relates a physician to the patient, to the practice environment, to the base of knowledge, and to the physician's own sense of self. Such a wo...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198812000-00022
更新日期:1988-12-01 00:00:00
abstract::Sepsis due to Pseudomonas aeruginosa continues to be an important source of morbidity and mortality in hospitalized patients. Early recognition of this condition is of paramount importance in choosing specific therapy at the earliest possible moment. We present three cases in which P aeruginosa bacteremia was manifest...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199402000-00017
更新日期:1994-02-01 00:00:00
abstract::A review of 228 cholecystectomies done over a two-year period revealed 15 cases (6.6%) in which gallstones were absent. These 15 patients were all characterized by colicky abdominal pain in the right upper quadrant, with a mean duration of eight months. Ultrasonographic examination was falsely positive for gallstones ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198811000-00005
更新日期:1988-11-01 00:00:00
abstract::Ovarian vein thrombophlebitis is often misdiagnosed because of vague symptoms leading to unnecessary surgery, morbidity, and mortality. CT findings in such a case are very useful in making a definite diagnosis of ovarian vein thrombophlebitis. We consider CT the preferred method for evaluating pain in the right lower ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198911000-00022
更新日期:1989-11-01 00:00:00
abstract::A 74-year-old man was admitted with rhabdomyolysis after undergoing initial treatment for gastrointestinal cancer with irinotecan. The syndrome partially resolved after the discontinuation of all of his usual medications, including his chronic selective serotonin reuptake inhibitor (SSRI). The rhabdomyolysis was exace...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000084311.35864.D6
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Among patients with pulmonary disease due to Mycobacterium avium complex (MAC) seen recently at our center, a substantial number have had extensive calcified mediastinal, hilar, and peribronchial lymphadenopathy, a finding historically inconsistent with pulmonary MAC disease. METHOD:We retrospectively studi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199906000-00005
更新日期:1999-06-01 00:00:00
abstract::We prospectively studied preoperative and postoperative grip and pinch strength in 21 patients having 30 consecutive median nerve decompressions for carpal tunnel syndrome. All procedures were done by one surgeon. Each hand operated on served as its own control and was studied by the same therapist preoperatively and ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199209000-00009
更新日期:1992-09-01 00:00:00
abstract::We report a rare case of Candida glabrata liver abscess and fungemia complicating severe calculus cholecystitis in a 64-year-old female patient who had no history of immunosuppression or diabetes mellitus. The patient underwent cholecystectomy, resection of liver abscess, and systemic antifungal therapy using micafung...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c9803b
更新日期:2010-03-01 00:00:00
abstract::This review assessed the overall effectiveness of repeated treatments with botulinum toxin type A (BoNTA) across different conditions, as documented in the published literature. Forty-four original research articles reporting on 16 different conditions were identified that included data on the duration or efficacy of ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000220888.88722.ab
更新日期:2006-08-01 00:00:00
abstract::Catheter emboli are a significant risk to patient well-being. With a 49% complication rate for indwelling catheter emboli, the consensus is that these foreign bodies should be removed. Preferably, the emboli are removed by percutaneous extraction; however, if the emboli are in the heart or central vasculature and perc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199607000-00013
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of laparoscopic Nissen fundoplication for esophageal reflux in a community hospital. METHODS:One hundred nineteen patients (76%) of 157 patients having laparoscopic fundoplication for symptomatic reflux disease completed a questionnaire. All patients were evaluated with esophagoscopy,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000146585.51335.76
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:In 2010, the American Heart Association unveiled a strategic plan to reduce cardiovascular deaths by targeting seven components of ideal cardiovascular health. Although education is a sensible first step, it is not known whether awareness correlates with healthy behavior. The objective of the study was to ex...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0000000000000013
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most frequent infections in intensive care units (ICUs), and nearly 50% of patients with VAP develop septic shock. Septic shock is an independent predictor for mortality in these patients. OBJECTIVE:To investigate the predictors for septic shock in VAP pat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181827891
更新日期:2008-12-01 00:00:00
abstract::To our knowledge, this is the first known case of a patient with leptospirosis and very elevated CSF, which caused hydrocephalus. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181a0ae80
更新日期:2009-05-01 00:00:00
abstract::The objective of this study was to determine the effect(s) of pregnancy and of advancing gestation on maternal serum amylase and lipase levels. Thus, serum amylase and lipase concentrations were quantitated in three groups of women. Groups included (1) 118 pregnant women whose serum amylase and lipase levels were meas...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007611-199602000-00008
更新日期:1996-02-01 00:00:00
abstract::An example of a blind-ending branch of a bifid ureter in a woman presenting with a urinary tract infection is reported. Definition, diagnosis, and treatment of this anomaly are discussed. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00031
更新日期:1979-07-01 00:00:00
abstract:OBJECTIVES:Adhesive capsulitis is characterized by a progressive and painful loss of shoulder motion of unknown etiology. Previous studies have found the prevalence of adhesive capsulitis to be slightly greater than 2% in the general population. However, the relationship between adhesive capsulitis and diabetes mellitu...
journal_title:Southern medical journal
pub_type: 杂志文章,多中心研究
doi:10.1097/SMJ.0b013e3181705d39
更新日期:2008-06-01 00:00:00