Abstract:
:Intravesical BCG (bacillus Calmette-Guérin) instillation is a first-line treatment for superficial transitional cell carcinoma of the bladder. A rare but severe complication of BCG immunotherapy is the development of disseminated BCG disease, which can result in miliary pneumonitis, granulomatous hepatitis, soft tissue infections, bone marrow involvement, and sepsis. Symptoms can present as early as a few hours or as late as several months following the BCG therapy. The key finding in disseminated BCG disease is the formation of caseating granulomas in distant organs; detection of BCG organisms from tissue samples can be difficult. Recommended treatment for disseminated BCG disease includes a combination of antituberculous medications (with the exception of pyrazinamide, to which BCG is typically resistant) and a tapering course of steroids. We present the cases of four patients who developed granulomatous infection consistent with disseminated disease after intravesical BCG treatment and provide a summary of current clinical management recommendations.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Nadasy KA,Patel RS,Emmett M,Murillo RA,Tribble MA,Black RD,Sutker WLdoi
10.1097/SMJ.0b013e31815d4047subject
Has Abstractpub_date
2008-01-01 00:00:00pages
91-5issue
1eissn
0038-4348issn
1541-8243pii
00007611-200801000-00029journal_volume
101pub_type
杂志文章abstract::The effectiveness of a screening device for urinary tract infection (Microstix**) was compared to routine laboratory cultures, sensitivities, and colony counts. The Microstix were highly effective in determining the presence or absence of urinary tract infections. In addition, they could be subcultured to provide mean...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract::One goal of primary care training programs is to provide "continuity experiences" for residents. Although programs funded by the Health Resources Administration are mandated to provide and evaluate such experiences, a wide variety may exist in both the concept and the evaluation of continuity in these training program...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198306000-00025
更新日期:1983-06-01 00:00:00
abstract::Women discharged from a municipal emergency department with the diagnosis of pelvic inflammatory disease were surveyed by telephone about their compliance with a standard 10-day regimen of doxycycline. Of the 386 women who completed the survey, 31% reported complete compliance; 28% reported that they did not fill thei...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199411000-00006
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To compare mobile health (mHealth) usage by residents of West Virginia with national estimates. METHODS:Pew Research Center data from its Internet and American Life Project were accessed for secondary data analysis. These data, available to the public, are a probability sample of Internet use in the United S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000879
更新日期:2018-10-01 00:00:00
abstract::Giant cell arteritis has been thought to occur only in white patients. There have been several recent reports of this disorder to blacks, however, and this case of biopsy-proven giant cell arteritis in a black patient indicates the diagnosis should be considered in any elderly patient with typical symptoms regardless ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00045
更新日期:1979-09-01 00:00:00
abstract::Atopic dermatitis (AD) is a common diagnosis seen in both children and adults, and it is often the first manifestation of atopic disease. Research has shown a strong correlation between serum IgE levels, the severity of atopic dermatitis, and co-existing asthma and/or allergic rhinitis. Omalizumab (Xolair, East Hanove...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181de0cf6
更新日期:2010-06-01 00:00:00
abstract::Arsenic poisonings occur in Mississippi despite public education campaigns to prevent poisonings in the home. We reviewed 44 Mississippi cases of arsenic exposures occurring from January 1986 to May 1990. We compared the epidemiologic differences between unintentional and intentional poisonings. Cases were found and c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199104000-00012
更新日期:1991-04-01 00:00:00
abstract::We compared a "cardiac profile" test with standard creatine kinase (CK) and lactic dehydrogenase (LD) electrophoresis in 798 cases of possible acute myocardial infarction (MI). The cardiac profile enzyme screen (CK-B, CK, LD) used on 495 patients who came to the emergency department with chest pain suggestive of acute...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:To compare grayscale and color Doppler ultrasound (CDUS) findings to that of multidetector computed tomography (MDCT) portography in the evaluation of portal hypertension in children. METHODS:Thirty children (mean age, 11.4 years) with definitive clinical and laboratory diagnoses of portal hypertension were...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31823cfae2
更新日期:2012-01-01 00:00:00
abstract::A unique case of Sheehan's syndrome is characterized by deficiencies of growth hormone, prolactin, thyrotropin, and ACTH. Clinically, it was manifested by adrenal and thyroid insufficiency with regular cyclical menses. Normal menstrual cycles do not preclude extensive hypothalamic-pituitary destruction. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198308000-00040
更新日期:1983-08-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common complication in patients with cirrhosis of the liver. The organisms most commonly involved in this infection are gram-negative bacteria like Escherichia coli and Klebsiella pneumoniae, and gram-positive bacteria like Streptococcus pneumoniae and Staphylococcus aureus...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-10-01 00:00:00
abstract::Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities. Six patients had relief of pain within five days of initiation of therapy. One patient had no pain relief despite mood alteration. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::A case of perforation and bleeding from a diverticulum of the second portion of the duodenum in a patient with recurrent pancreatitis is presented. Upper gastrointestinal roentgenogram revealed an abnormal tract and retroperitoneal air arising from the diverticulum. The fistulous tract communicated with pancreas. Blee...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197706000-00037
更新日期:1977-06-01 00:00:00
abstract::Chronic myelomonocytic leukemia (CMML) is a relatively rare, heterogeneous syndrome classified as a myelodysplastic syndrome according to the French-American-British classification system. The patient's presenting symptom was a pigmented skin nodule that, although common for cases of acute monoblastic leukemia, is pec...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000054224.50737.4C
更新日期:2003-07-01 00:00:00
abstract::Symptoms of hyperphosphatemia usually relate to the associated hypocalcemia. In a 33-year-old patient accidental infusion of a bolus of potassium phosphate (5 ml intravenously) was immediately followed by cardiac arrest. During CPR, clinically important hypocalcemia or hyperkalemia was not detected, but serum phosphor...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVES:To explore factors that might contribute to misattribution of mental status changes to psychiatric illness when an elderly patient actually has a delirium (mental status changes due to a medical condition). METHODS:Records of 900 elderly patients referred to a Veterans Affairs psychiatric inpatient unit and...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c99423
更新日期:2010-02-01 00:00:00
abstract::Blastomycosis in children is relatively infrequent. Further, osteomyelitis of the frontal bone, which prior to the antibiotic era occurred more frequently and was mostly due to pyogenic cocci, is rare today. We described a case of frontal osteomyelitis in a child due to blastomycosis which occurred in the absence of f...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197802000-00028
更新日期:1978-02-01 00:00:00
abstract::Transfusion in the pediatric age group requires careful consideration of the patient's weight and age because of potential problems with intravascular volume and difficulty with administration of the blood product. Different age groups have varied disease processes that require specific blood components. A correct dia...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract::Seventeen patients with Crohn's disease requiring emergency operative procedures disclosed important factors leading to successful outcome. In seven of the ten patients not known to have Crohn's disease, the history strongly suggested this diagnosis. Two patients died; three others had major complications, including t...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197810000-00010
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:This study was done to determine the accuracy of the 2 x 2 cm pocket identifying low amniotic fluid (AF) volume in singleton and twin pregnancies. METHODS:The AF volume was evaluated by ultrasonography for the presence of a 2 x 2 cm pocket before amniocentesis. The actual AF volume was then determined by a ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199908000-00011
更新日期:1999-08-01 00:00:00
abstract::Chemotherapy with radiation has become more popular than radiotherapy alone for patients with locally advanced head and neck cancer because of the successful results associated with it. We report the case of a 67-year-old man with hypopharyngeal cancer invading the prevertebral fascia who became free of disease after ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000125170.34916.FB
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:In 2014, 726 bicyclists were killed and an additional 50,000 were injured in crashes with motor vehicles. The number of cyclists in the United States is increasing, and as a result there has been a call for more bike lanes. We examined the difference in the severity of injury of bicyclists involved in motor ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000665
更新日期:2017-07-01 00:00:00
abstract::Treatment of the adult respiratory distress syndrome requires an understanding of the current concepts of the pathogenesis of this syndrome. The clinical features and pathophysiology are briefly discussed. Differential diagnosis requires the exclusion of pulmonary infection and left heart failure. Therapy is aimed at ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-197811000-00028
更新日期:1978-11-01 00:00:00
abstract::This report describes a 9-year-old girl with pigmented villonodular synovitis of the right knee. She presented with a chronic bloody effusion of the knee. The diagnosis of pigmented villonodular synovitis was suggested by the findings on magnetic resonance imaging and confirmed at the time of arthroscopic synovectomy....
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000104842.97001.88
更新日期:2004-01-01 00:00:00
abstract::Among natural disasters, lightning is a leading cause of morbidity and mortality throughout the world. A well-informed bystander and an astute physician can make the difference between an outcome of death or lifelong disability versus complete or near-complete recovery. What is done in the first few minutes after such...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199907000-00010
更新日期:1999-07-01 00:00:00
abstract::Recent investigations of outbreaks of Salmonella enteritidis gastroenteritis among humans, especially in the northeastern United States, implicate grade A shell chicken eggs as the likely vehicle of transmission. In April 1991 we investigated an outbreak of S enteritidis infections after a wedding anniversary celebrat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199312000-00005
更新日期:1993-12-01 00:00:00
abstract::We reviewed the operative complications in 333 living related donor nephrectomies done at our institution over the past 12 years. The overall complication rate was 17.1%; only three patients (0.9%) had major complications, and none died. The major complications were a delayed splenectomy because of bleeding, an adrena...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199401000-00013
更新日期:1994-01-01 00:00:00
abstract::During the last 50 years, it has become evident that atherosclerosis originates in childhood. Although cardiovascular disease (CVD) events are rare in children, autopsy data and imaging studies have documented subclinical disease in association with measurable risk factors during childhood. When present at a young age...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000219
更新日期:2015-01-01 00:00:00
abstract::A man who received therapeutic irradiation to limited areas of each lung for intrapulmonary Hodgkin's disease developed bronchioalveolar carcinoma in the same areas more than 20 years later. This is the first report of a malignant process developing in areas of the lung that had been previously irradiated for treatmen...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198305000-00046
更新日期:1983-05-01 00:00:00
abstract::During the spring term of 1975, rubella was diagnosed in 23 students at Georgetown University in Washington, DC. The cases were concentrated among students from the School of Foreign Service and their close contacts; outbreaks did not appear in other divisions of the university. Rubella immunization of susceptible fem...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-08-01 00:00:00