Abstract:
:During pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic systems that appears to have evolved to sustain this metabolic regulation is mediated by peroxisome proliferator-activated receptors (PPARs). In clinical pregnancy-specific disorders, including preeclampsia, gestational diabetes, and intrauterine growth restriction, aberrant regulation of components of the PPAR system parallels dysregulation of metabolism, inflammation and angiogenesis. This review summarizes current knowledge on the role of PPARs in regulating human trophoblast invasion, early placental development, and also in the physiology of clinical pregnancy and its complications. As increasingly indicated in the literature, pregnancy disorders, such as preeclampsia and gestational diabetes, represent potential targets for treatment with PPAR ligands. With the advent of more specific PPAR agonists that exhibit efficacy in ameliorating metabolic, inflammatory, and angiogenic disturbances, further studies of their application in pregnancy-related diseases are warranted.
journal_name
PPAR Resjournal_title
PPAR researchauthors
Wieser F,Waite L,Depoix C,Taylor RNdoi
10.1155/2008/527048subject
Has Abstractpub_date
2008-01-01 00:00:00pages
527048eissn
1687-4757issn
1687-4765journal_volume
2008pub_type
杂志文章相关文献
PPAR Research文献大全abstract::Inflammation is a major component in the pathology of chronic lung diseases, including asthma. Anti-inflammatory treatment with corticosteroids is not effective in all patients. Thus, new therapeutic options are required to control diverse cellular functions that are currently not optimally targeted by these drugs in ...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/14983
更新日期:2007-01-01 00:00:00
abstract::Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 ma...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2011/647017
更新日期:2011-01-01 00:00:00
abstract::INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor gamma modulator (SPPARM) currently in Phase 2 clinical trials for treatment of type-2 diabetes mellitus (T2DM). This new chemical entity represents a second generation SPPARM approach d...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/936906
更新日期:2008-01-01 00:00:00
abstract::Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a poss...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2018/6738703
更新日期:2018-01-15 00:00:00
abstract::Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of g...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/461981
更新日期:2008-01-01 00:00:00
abstract::It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/PPAR/2006/96341
更新日期:2006-01-01 00:00:00
abstract::Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. Ho...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/245410
更新日期:2008-01-01 00:00:00
abstract::Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose effects result predominantly from its modulation of the transcriptional activity of peroxisome proliferator-activated-receptor-gamma (PPARγ). Pio is used to treat human insulin-resistant diabetes and also frequently considered for treatment...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2020/3817573
更新日期:2020-09-10 00:00:00
abstract::PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark o...
journal_title:PPAR research
pub_type: 杂志文章,评审
doi:10.1155/2020/3608315
更新日期:2020-08-13 00:00:00
abstract::Cells can shift their metabolism between glycolysis and oxidative phosphorylation to enact their cell fate program in response to external signals. Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2020/3785137
更新日期:2020-02-01 00:00:00
abstract::Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the effect of fenofibrate, a PPAR-α agonist, on serum irisin in type 2 diabetes patients with hypertriglyceridemia. Th...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2015/924131
更新日期:2015-01-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is a ubiquitous nuclear DNA-binding protein whose function is dependent on its cellular location. Extracellular HMGB1 is regarded as a delayed mediator of proinflammatory cytokines for initiating and amplifying inflammatory responses, whereas nuclear HMGB1 has been found to prevent ca...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2014/541394
更新日期:2014-01-01 00:00:00
abstract::Improvements in our understanding of the functions of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) subtypes as pleiotropic regulators of biological responses, including lipid, lipoprotein, glucose homeostasis, inflammation, differentiation and proliferation of various cancer cells, and memory...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/689859
更新日期:2008-01-01 00:00:00
abstract::Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties called glioma stem cells (GSCs). Therefore, new therapeutic strategies GSC-targete...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2016/7175067
更新日期:2016-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agoni...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2011/840194
更新日期:2011-01-01 00:00:00
abstract::Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/49671
更新日期:2007-01-01 00:00:00
abstract::The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie at the heart of these developments have enabled the design of a new class of PPARγ ligands, capab...
journal_title:PPAR research
pub_type: 杂志文章,评审
doi:10.1155/2020/9657380
更新日期:2020-07-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In additi...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/614852
更新日期:2008-01-01 00:00:00
abstract::The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has...
journal_title:PPAR research
pub_type: 杂志文章,评审
doi:10.1155/2016/2308249
更新日期:2016-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, prolif...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/254108
更新日期:2008-01-01 00:00:00
abstract::Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and f...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2011/261584
更新日期:2011-01-01 00:00:00
abstract::The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis. In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARdelta, triggers a transcriptio...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/172676
更新日期:2008-01-01 00:00:00
abstract::Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into adipocytes. We hypothesize that protein farnesylation is required fo...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/81654
更新日期:2007-01-01 00:00:00
abstract::PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...
journal_title:PPAR research
pub_type: 杂志文章,收录出版
doi:10.1155/2007/48242
更新日期:2007-01-01 00:00:00
abstract::The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipoge...
journal_title:PPAR research
pub_type: 杂志文章,评审
doi:10.1155/2015/358029
更新日期:2015-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This implies modulation of female sex steroid hormones by PPARγ. It is not clear if...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2009/101857
更新日期:2009-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of reproductive age. Familial clustering of PCOS has been consistently reported suggesting that genetic factors play a role in the development of the syndrome although PCOS cases do not exhibit a clear pattern of Mendelian inheritance....
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/49109
更新日期:2007-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-gamma acts as a key regulator of the adipogenesis. Since several cytokines (IL-1, TNF-alpha, TGF-beta) had been known to inhibit ad...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2010/341671
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS:We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS:The PPARα intron 7 G/C po...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2017/7636019
更新日期:2017-01-01 00:00:00
abstract::Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B(4) receptor pathway and the PPARgamma pathway as potential targets for prevention or treatment of this disease. LY293111 was originally designed as a potent ...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/827096
更新日期:2008-01-01 00:00:00