Abstract：
PURPOSE:The purpose of this study was to test the response of the mouse eye to two methods for the induction of experimental myopia. METHODS:Growth patterns of eyes were determined by axial length measurements from birth to adult in eyes of both sexes of normal mice examined on post-natal day 1 to 6 months and at 1 year. For the induction of experimental myopia, Balb/cJ mice were prepared with either unilateral lid suture or by a -10D spectacle lens placed over one eye at post-natal day 10. Other mice received a plano lens as a control for lens wear. Refraction was carried out at post-natal days of 28, 42 and 56 in lid suture and spectacle lens wear group by streak retinoscopy. Axial length was measured by a combination of video image photography, digital caliper, or Optical Low Coherence Interferometry (OLCI). Corroborative optical modeling of the mouse eye was carried out using ZEMAX ray tracing software. RESULTS:Axial length (AL) increased linearly between post-natal day 1 to day 56, plateauing at about 140 days. After 18 days of unilateral lid suture initiated 10 days after birth, the AL of experimental eyes was 3.032+/-0.003 mm, while AL in contra-lateral control eyes was 2.981+/-0.005 mm (mean+/-sem, p<0.05, n=40), after 32 days, the AL of experimental eyes was 3.290+/-0.004 mm, and the AL of control eyes was 3.104+/-0.002 mm (p<0.001, n=60). After 46 days of lid closure AL of experimental eyes was 3.592+/-0.003 mm, while AL of control eyes was 3.363+/-0.003 mm (p<0.001, n=80). Spectacle lens wear of 46 days duration increased AL in experimental eyes to 3.721+/-0.002 mm, while AL in control eyes was 3.354+/-0.003 mm (p<0.001, n=100). Refraction and ray tracing analysis substantiated the dimensional changes to be consistent with increased AL. CONCLUSIONS:Two procedures to induce experimental myopia, initiated at eye opening, produced significant myopic shifts corresponding to increases in axial lengths after 32 and 46 days of lid suture and after 46 days wearing a -10D spectacle lens.
journal_name
Vision Resjournal_title
Vision researchauthors
Barathi VA,Boopathi VG,Yap EP,Beuerman RWdoi
10.1016/j.visres.2008.01.004subject
Has Abstractpub_date
2008-03-01 00:00:00pages
904-16issue
7eissn
0042-6989issn
1878-5646pii
S0042-6989(08)00023-0journal_volume
48pub_type
杂志文章相关文献
VISION RESEARCH文献大全abstract：:In human far peripheral vision, drifting stimuli of particular periodicities appear to move in the opposite direction from their true direction of motion. This "reverse motion illusion" is a consequence of spatial undersampling of the retinal image. The illusion occurs for spatial frequencies an order of magnitude low...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(90)90031-f
更新日期：1990-01-01 00:00:00
abstract：:The aim of the study was to determine the age-dependence of the accommodative force on the lens in order to make it clear whether the causes of presbyopia are due to lenticular or extralenticular changes. A finite element model of the lens of an 11-, 29- and 45-year-old human eye was constructed to represent the fully...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2007.10.017
更新日期：2008-01-01 00:00:00
abstract：:A major factor underlying the prolonged postnatal improvement of visual acuity in primates is an increase in the sampling limit imposed by the photoreceptor mosaic, which may be as much as 5-fold. Further factors operating peripheral to neurons of the lateral geniculate nucleus, which might include changes in neural c...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(88)90104-6
更新日期：1988-01-01 00:00:00
abstract：:A simple electrophysiological method is described for determining the effective optical density of the intracellular pupil mechanism of insect photoreceptor cells. The method depends on the fact that the photoreceptors can not only be illuminated in the normal, orthodromic way, but also antidromically, i.e. from the b...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(90)90178-n
更新日期：1990-01-01 00:00:00
abstract：:Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and ca...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2009.10.013
更新日期：2010-03-31 00:00:00
abstract：:A task-irrelevant stimulus can distort recall from visual short-term memory (VSTM). Specifically, reproduction of a task-relevant memory item is biased in the direction of the irrelevant memory item (Huang & Sekuler, 2010a). The present study addresses the hypothesis that such effects reflect the influence of neural a...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2013.12.016
更新日期：2014-03-01 00:00:00
abstract：:Saleh and Bonnet [Fechner Day 98, p. 344] have shown that, upon parafoveal stimulation and up to 6.5 c/deg, reaction time (RT) is a function of grating contrast multiplied by grating period. The present experiments extend these findings to foveal stimulation within a wider spatial-frequency (SF) range and to stimuli o...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(01)00300-5
更新日期：2002-03-01 00:00:00
abstract：:We present a method for recording eye-head movements with the magnetic search coil technique in a small external magnetic field. Since magnetic fields are typically non-linear, except in a relative small region in the center small field frames have not been used for head-unrestrained experiments in oculomotor studies....
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2010.03.017
更新日期：2010-06-18 00:00:00
abstract：:Age related changes in the dynamics of accommodation (far to near focus) and disaccommodation (near to far focus) are reported in this study. Dynamic responses to step stimulus demands from 1D to 6D, in 1D steps, were recorded with a PowerRefractor in 66 subjects in the age range 14-45 years. The accommodative and dis...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2005.11.012
更新日期：2006-04-01 00:00:00
abstract：:Most humans seem to demonstrate astonishingly high levels of skill in face processing if one considers the sophisticated level of fine-tuned discrimination that face recognition requires. However, numerous studies now indicate that the ability to process faces is not as fundamental as once thought and that performance...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2016.07.007
更新日期：2016-10-01 00:00:00
abstract：:When our eyes are tracking a target that is moving in front of a structured background, global motion of equal speed is induced in the opposite direction. This effect has been termed reafference, which, astonishingly, does not significantly affect the execution of such pursuit eye movements. Employing brief and unexpe...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(01)00050-5
更新日期：2001-06-01 00:00:00
abstract：:We have found evidence for ultraviolet visual capabilities in a Lake Malawi cichlid fish, Metriaclima zebra. Microspectrophotometry of single cones revealed a visual pigment with peak sensitivity at 368+/-4 nm. M. zebra also expresses a putative ultraviolet opsin gene whose sequence is closely related to the SWS-1 ops...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(99)00238-2
更新日期：2000-01-01 00:00:00
abstract：:Most laboratory visual search tasks involve many searches for the same target, while in the real world we typically change our target with each search (e.g. find the coffee cup, then the sugar). How quickly can the visual system be reconfigured to search for a new target? Here observers searched for targets specified ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2003.11.024
更新日期：2004-06-01 00:00:00
abstract：:It is generally held that protanopes and deuteranopes see only regions of blues and yellows in the visible spectrum, with an achromatic point, called the neutral point, separating these regions. Considerations of a zone model of color vision for the dichromatic observer led us to predict that a reduced form of red/gre...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(87)90013-7
更新日期：1987-01-01 00:00:00
abstract：:Prior research has suggested that two types of fast eye movements (FEMs) can be distinguished behaviorally. Foveating saccades respond to salient peripheral targets by directing the target image to the fovea. Non-foveating saccades include other FEMs such as nystagmus quick phase, saccades without visual stimuli and v...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(91)90173-3
更新日期：1991-01-01 00:00:00
abstract：:It was hypothesized that egg-laying Papilio butterflies could use polarizational colours as a cue to detect leaf orientation and to discriminate between shiny and matt leaves. These hypotheses would be supported if the following general questions were answered positively: (1) Can surface orientation be unambiguously c...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2004.05.004
更新日期：2004-01-01 00:00:00
abstract：:A long-wavelength background can affect the appearance of an increment of light superimposed upon it in two ways. It can change the visual system's sensitivity to the increment, and it can change the appearance of the increment by directly adding redness to it. Through selective retinal-image stabilization, we evoked ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(93)90155-p
更新日期：1993-01-01 00:00:00
abstract：:Primate eyes display considerable oblique off-axis astigmatism which could provide information on the sign of defocus that is needed for emmetropization. The pattern of peripheral astigmatism is not known in the chicken eye, a common model of myopia. Peripheral astigmatism was mapped out over the horizontal visual fie...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2015.02.002
更新日期：2015-04-01 00:00:00
abstract：:Chromatic induction from patterned backgrounds depends on the spatial as well as the chromatic aspects of the background light. Color appearance with patterned and uniform backgrounds was compared using chromaticities distinguished by only the S cones; all backgrounds were equivalent to equal-energy white in terms of ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2003.11.004
更新日期：2004-04-01 00:00:00
abstract：:It is commonly believed that objects viewed in certain contexts may be more or less salient. Measurements of salience have usually relied on asking observers "How much does this object stand out against the background?". In this study, we measured the salience of objects by assessing the distraction they produce for s...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2005.01.013
更新日期：2005-06-01 00:00:00
abstract：:We determined the effect upon accommodative responses of tinted lenses prescribed for the relief of visual discomfort in a group of five long term lens wearers. Static and dynamic responses were measured under four viewing conditions (1) prescribed tinted lens (2) neutral density filter (3) tinted lens of complementar...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(00)00291-1
更新日期：2001-04-01 00:00:00
abstract：:We report a series of nine experiments which show that a single roll-tilted line in darkness induces changes of the orientation perceived as vertical (VPV) that are similar in magnitude and direction to those measured by Witkin and Asch (1948a) [Studies in space orientation. I. Perception of the upright with displaced...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2005.01.014
更新日期：2005-07-01 00:00:00
abstract：:When a vernier stimulus is presented for a short time and followed by a grating comprising five straight lines, the vernier remains invisible but may bequeath its offset to the grating (feature inheritance). For more than seven grating elements, the vernier is rendered visible as a shine-through element. However, shin...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(01)00122-5
更新日期：2001-08-01 00:00:00
abstract：:Seven models of human visual recognition from cognitive psychology, visual psychophysics and connectionism were compared. They were used to predict psychophysical classification data obtained via supervised learning with parametrised grey-level patterns (compound Gabor signals). Four sets of learning patterns, as well...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/s0042-6989(97)00396-9
更新日期：1998-08-01 00:00:00
abstract：:We hypothesized that it is the conflict between various cues to distance that have produced results purportedly showing that vergence eye movements induced by disparity change are not an effective cue for depth. Single and compound stimuli were used to examine the perceived motion in depth (MID) produced by simulated ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2009.11.005
更新日期：2010-01-01 00:00:00
abstract：:Qualitative defects and resistances in 94 used gold foil electrodes were examined. The electrodes were divided into four groups of varying resistances and gold coating defects. Ten were randomly selected from each group to measure standard photopic electroretinograms (ERGs) in a normal subject. Ten new electrodes were...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(95)00046-3
更新日期：1995-10-01 00:00:00
abstract：:Stereoscopic depth is most useful when it comes from relative rather than absolute disparities. However, the depth perceived from relative disparities can vary with stimulus parameters that have no connection with depth or are irrelevant to the task. We investigated observers' ability to judge the stereo depth of task...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/j.visres.2018.08.007
更新日期：2019-05-01 00:00:00
abstract：:In adult golden hamsters (Mesocricetus auratus), the optic nerve was bilaterally sectioned with one side grafted with the sciatic nerve to make a bridge to the ipsilateral superior colliculus. Shuttle-box avoidance was tested using light as the conditioned stimulus. Three of the five transplanted animals revealed stat...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(93)90070-d
更新日期：1993-05-01 00:00:00
abstract：:The sensitivity of X- and Y-cells in the dorsal lateral geniculate nucleus of the cat to small, temporally modulated displacements of grating stimuli was measured at 0.175, 0.25, 0.50, 1.00, and 2.00 c/deg. For every cell, two threshold measures were determined: first, a contrast threshold with a counterphase grating ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(86)90037-4
更新日期：1986-01-01 00:00:00
abstract：:The eyespots in cells of streptomycin-bleached strains and of dark-grown cultures of Euglena gracilis, were examined by means of fluorescence microscopy and microspectrophotometry. When viewed with light in the region of 380-500 nm, the stigma appeared as a dark spot. Adjacent to this was a second spot, not seen with ...
journal_title：Vision research
pub_type： 杂志文章
doi：10.1016/0042-6989(92)90151-8
更新日期：1992-09-01 00:00:00
