The clinical consequences of the absorption, distribution, metabolism and excretion of amlodipine.

abstract：:A 19-year-old girl developed generalised anhidrosis following typhoid fever. Elaborate investigations disclosed nothing abnormal. A skin biopsy revealed the presence of atrophic as well as normal eccrine glands. This appears to be the third case of its kind in the English literature. It is postulated that typhoid feve...

journal_title：Postgraduate medical journal

authors： Raveenthiran V

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF THE STUDY:To explore which factors increase the likelihood of being deemed appointable to core anaesthesia training in the UK and whether those factors subsequently predict performance in postgraduate training. STUDY DESIGN:Observational study linking UK medical specialty recruitment data with postgraduate ...

journal_title：Postgraduate medical journal

authors： Aslet M,Paton LW,Gale T,Tiffin PA

更新日期：2020-01-01 00:00:00

abstract：:The effect of graded exercise on the secretion of cortisol, testosterone, prolactin, growth hormone, thyroid stimulating hormone (TSH), luteinizing hormone and follicle stimulating hormone (FSH) is reported. While cortisol, prolactin, growth hormone and testosterone rise during the period of exercise, a rise in lutein...

journal_title：Postgraduate medical journal

authors： Gawel MJ,Park DM,Alaghband-Zadeh J,Rose FC

更新日期：1979-06-01 00:00:00

abstract：:Twenty-four hour intragastric acidity was measured in nine volunteer subjects in a single-blind placebo-controlled cross-over study comparing the effects of famotidine with ranitidine. The volunteer subjects received famotidine (40 mg at night), famotidine (20 mg at night), ranitidine (300 mg at night) or placebo in a...

journal_title：Postgraduate medical journal

authors： Santana IA,Lanzon-Miller S,Pounder RE

更新日期：1986-01-01 00:00:00

abstract：:The authors present the case report of a child with abdominal epilepsy who had suffered from abdominal pain for several months under the label of psychogenic pain. The important historical clues were pallor and cold sweating during the paroxysm, followed by lethargy and prolonged sleep. An abnormal electroencephalogra...

journal_title：Postgraduate medical journal

authors： Singhi PD,Kaur S

更新日期：1988-04-01 00:00:00

abstract：:Long lists of causes of peripheral neuropathy make peripheral nerve disease a dry and uninspiring subject. A simple scheme based on the answers to just six questions should enable the clinician to recognise characteristic patterns, investigate relevant subgroups appropriately, and identify treatable disorders quickly:...

journal_title：Postgraduate medical journal

authors： Overell JR

更新日期：2012-02-01 00:00:00

abstract：:The marked decline in coronary heart disease mortality in the United States since the late 1960s is most likely due in large part to successful efforts at primary prevention, attributable in turn to improved eating habits, better control of blood pressure and a reduction in smoking. Another part of the decline can pro...

journal_title：Postgraduate medical journal

authors： Epstein FH

更新日期：1984-01-01 00:00:00

abstract：:A patient with alcoholic cardiomyopathy is described in whom cardiovascular function capacity and radiological heart size fluctuated widely with periods of heavy drinking and abstinence. On two occasions, cessation of drinking resulted in clinical recovery from severe degrees of congestive failure and in complete reve...

journal_title：Postgraduate medical journal

authors： Kupari M

更新日期：1984-02-01 00:00:00

abstract：:A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious dise...

journal_title：Postgraduate medical journal

authors： Fernandez-Miranda C,Mateo S,Gonzalez-Gomez C,Ballestin C

更新日期：1994-07-01 00:00:00

abstract：:Five patients with apparent adverse cardiovascular effects of disopyramide are reveiwed. Attention is drawn to the following problems. (1) A vagolytic effect may produce a sinus tachycardia with wide QRS complexes due to aberrant conduction or intraventricular block superficially resembling a ventricular tachycardia, ...

journal_title：Postgraduate medical journal

authors： Warrington SJ,Hamer J

更新日期：1980-04-01 00:00:00

abstract：:Two patients, one of whom was pregnant, developed superior vena caval thrombosis while receiving central parenteral nutrition. They were successfully treated with recombinant tissue plasminogen activator (t-PA). ...

journal_title：Postgraduate medical journal

authors： Barclay GR,Allen K,Pennington CR

更新日期：1990-05-01 00:00:00

abstract：:Fifteen patients who had undergone a 14 inches X 4 inches jejuno-ileal bypass operation for obesity, 3 to 4 years earlier, were investigated by iliac bone biopsy, radiology and routine biochemistry, including 25-hydroxy-vitamin D and parathyroid hormone estimations. Two patients had histological osteomalacia which was...

journal_title：Postgraduate medical journal

authors： Gilmore IT,Eastwood JB,Ellis WR,Luck VA,Fenton S,O'Grady AJ,Harris E,Murray-Lyon IM

更新日期：1983-05-01 00:00:00

abstract：:We describe the case of an acromegalic woman with primary infertility who was treated with clomiphene, and subsequently developed pituitary apoplexy. ...

journal_title：Postgraduate medical journal

authors： Walker AB,Eldridge PR,MacFarlane IA

更新日期：1996-03-01 00:00:00

abstract：:Herniation of a thoracic disc in an acromegalic giant is reported. Degenerative changes in the spine in association with dorsal kyphosis, and the additional strain, resulted in the disc prolapse. ...

journal_title：Postgraduate medical journal

authors： Chhang WH,Sharma BS,Dash RJ,Kak VK

更新日期：1989-07-01 00:00:00

abstract：:Both the quality and the quantity of food ingested are relevant to the genesis of risk factors for coronary heart disease and the two are inseparable. Nevertheless they have a major common pathway through hypertension, which may well be the most important consequence of a high-protein, high-carbohydrate, high-fat, hig...

journal_title：Postgraduate medical journal

authors： Brook CG

更新日期：1978-03-01 00:00:00

abstract：:Evidence is now accumulating on both clinical and experimental grounds that the retina is an a priori source of inflammatory activity. Reactive inflammation in the retina may produce many of the clinical signs previously ascribed to uveal inflammation. Autoimmune mechanisms are probably responsible for the majority of...

journal_title：Postgraduate medical journal

authors： Sanders MD,Graham EM

更新日期：1988-07-01 00:00:00

abstract：:Mathematical techniques are well suited to analysis of growth data. In the past there has been much emphasis on the mathematical description of shape and changes of shape as exemplified by the allometric equation. More recently these methods have been less popular and shape analysis has been handled largely by modern ...

journal_title：Postgraduate medical journal

authors： Preece MA

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Aortic dissection is a life-threatening cardiovascular disease with high mortality. Little is known about comparisons of the clinical characteristics or the factors that influence the long-term prognosis of Chinese patients with aortic dissection with and without Marfan syndrome (MFS). METHODS:The authors s...

journal_title：Postgraduate medical journal

authors： Linggen G,Lin Z,Xiaohan F,Haiying W,Xianliang Z,Rutai H

更新日期：2011-05-01 00:00:00

abstract：:A 12-year-old boy presented with typical features of short incubation tetanus. Spastic paraparesis with a mid-thoracic sensory level was present from the time of the initial examination. X-rays of the spine and lumbar myelogram were normal. The paraparesis improved rapidly and within a month the patient was free of ne...

journal_title：Postgraduate medical journal

authors： Bahemuka M

更新日期：1981-07-01 00:00:00

abstract：:As a tertiary referral centre of spinal surgery, the Royal National Orthopaedic Hospital (RNOH) handles hundreds of spinal cases a year, often with complex pathology and complex care needs. Despite this, issues were raised at the RNOH following lack of sufficient documentation of preoperative and postoperative clinica...

journal_title：Postgraduate medical journal

authors： Pace V,Farooqi O,Kennedy J,Park C,Cowan J

更新日期：2018-05-01 00:00:00

abstract：:New-onset seizures are frequent manifestations of central nervous system disorders in patients infected with human immunodeficiency virus (HIV). Seizures are more common in advanced stages of the disease, although they may occur early in the course of illness. In the majority of patients, seizures are of the generalis...

journal_title：Postgraduate medical journal

authors： Garg RK

更新日期：1999-07-01 00:00:00

abstract：:This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis. ...

journal_title：Postgraduate medical journal

authors： D'Costa DF,Vania AK,Millac PA

更新日期：1990-10-01 00:00:00

abstract：:A patient is described in whom the presenting feature of hypopituitarism was the development of palmar xanthomata associated with type III hyperlipoproteinaemia. Treatment of her secondary hypothyroidism with thyroxine caused resolution of the xanthomata and hyperlipidaemia, but the underlying compositional abnormalit...

journal_title：Postgraduate medical journal

authors： Carr D,Thornes HM,Rutter AC,Finney RD,Turner PR

更新日期：1987-12-01 00:00:00

abstract：:A patient is described who developed acute peripheral neuropathy of Guillain-Barré type occurring shortly after commencement of captopril for moderately severe hypertension and resolving after discontinuation of the drug. ...

journal_title：Postgraduate medical journal

authors： Chakraborty TK,Ruddell WS

更新日期：1987-03-01 00:00:00

abstract：:In a cross-over study, 10 healthy adult volunteers received 1 g cefaclor and 1 g cephalexin orally 1 hour after a standard breakfast. Serum levels of cefaclor rose somewhat faster and were higher than those of cephalexin in the first 60 minutes. At the end of the second hour the serum concentration of cephalexin was 5...

journal_title：Postgraduate medical journal

authors： Simon C,Gatzemeier U

更新日期：1979-01-01 00:00:00

abstract：:Forty patients with seasonal rhinitis and a proven sensitivity to pollens were studied for 2 weeks during the pollen season of 1982. The study was carried out according to a double-blind, double-dummy design. All patients received 100 micrograms beclomethasone dipropionate (BDP) into each nostril twice daily (400 micr...

journal_title：Postgraduate medical journal

authors： Dunn AM,Wilson RS,Baggott PJ

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:Large population studies now demonstrate that frailty is prevalent in all adult age groups. Limited data exist on the association between frailty and surgical outcome in younger patients. The aim of the study was to explore the agreement between frailty identification tools and collect pilot data on their predi...

journal_title：Postgraduate medical journal

authors： Dale MacLaine T,Baker O,Burke D,Howell SJ

更新日期：2021-01-12 00:00:00

abstract：:The clinical significance of the abnormalities seen at left ventriculography in ischaemic heart disease is discussed. Aneurysms may be recognized when left ventriculography is combined with coronary arteriography to show the characteristic obliteration of the supplying artery. Localized areas of abnormal contraction s...

journal_title：Postgraduate medical journal

authors： Khattri HN,Raphael MJ,Sharma B,Steiner RE,Goodwin JF

更新日期：1978-01-01 00:00:00

abstract：:Rectal (both digital and rigid sigmoidoscopic) examination is an important part of the clinical examination. The aim of this study was to find out the opinions of the patients to this routine examination at the time of referral by their general practitioner and during their first hospital interview. Assessment of the ...

journal_title：Postgraduate medical journal

authors： Ng DP,Mayberry JF,McIntyre AS,Long RG

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. METHODS:Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to...

journal_title：Postgraduate medical journal

authors： Mackay DF,Irfan MO,Haw S,Pell JP

更新日期：2011-04-01 00:00:00