Effect of oral famotidine on 24-hour intragastric acidity.

Abstract:

:Twenty-four hour intragastric acidity was measured in nine volunteer subjects in a single-blind placebo-controlled cross-over study comparing the effects of famotidine with ranitidine. The volunteer subjects received famotidine (40 mg at night), famotidine (20 mg at night), ranitidine (300 mg at night) or placebo in a predetermined random order. Twenty-four hour intragastric acidity was measured after the seventh dose of each drug or placebo. Famotidine (20 mg), famotidine (40 mg) and ranitidine, all caused a significant decrease of intragastric nocturnal acidity when compared with placebo (P less than 0.01), with no effect during the daytime (P greater than 0.05). Treatment with all the drugs caused a significant rise of fasting plasma gastrin concentration compared with placebo (P less than 0.05).

journal_name

Postgrad Med J

authors

Santana IA,Lanzon-Miller S,Pounder RE

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

39-42

eissn

0032-5473

issn

1469-0756

journal_volume

62 Suppl 2

pub_type

临床试验,杂志文章,随机对照试验
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