Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling.

Abstract:

:Orexin-producing neurons are clearly essential for the regulation of wakefulness and sleep because loss of these cells produces narcolepsy. However, little is understood about how these neurons dynamically interact with other wake- and sleep-regulatory nuclei to control behavioral states. Using survival analysis of wake bouts in wild-type and orexin knockout mice, we found that orexins are necessary for the maintenance of long bouts of wakefulness, but orexin deficiency has little impact on wake bouts <1 min. Since orexin neurons often begin firing several seconds before the onset of waking, this suggests a surprisingly delayed onset (>1 min) of functional effects. This delay has important implications for understanding the control of wakefulness and sleep because increasing evidence suggests that different mechanisms are involved in the production of brief and sustained wake bouts. We incorporated these findings into a mathematical model of the mouse sleep/wake network. Orexins excite monoaminergic neurons and we hypothesize that orexins increase the monoaminergic inhibition of sleep-promoting neurons in the ventrolateral preoptic nucleus. We modeled orexin effects as a time-dependent increase in the strength of inhibition from wake- to sleep-promoting populations and the resulting simulated behavior accurately reflects the fragmented sleep/wake behavior of narcolepsy and leads to several predictions. By integrating neurophysiology of the sleep/wake network with emergent properties of behavioral data, this model provides a novel framework for investigating network dynamics and mechanisms associated with normal and pathologic sleep/wake behavior.

journal_name

J Neurophysiol

authors

Diniz Behn CG,Kopell N,Brown EN,Mochizuki T,Scammell TE

doi

10.1152/jn.01243.2007

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

3090-103

issue

6

eissn

0022-3077

issn

1522-1598

pii

01243.2007

journal_volume

99

pub_type

杂志文章
  • On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli.

    abstract::Understanding neural responses with natural stimuli has increasingly become an essential part of characterizing neural coding. Neural responses are commonly characterized by a linear-nonlinear (LN) model, in which the output of a linear filter applied to the stimulus is transformed by a static nonlinearity to determin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01397.2007

    authors: Sharpee TO,Miller KD,Stryker MP

    更新日期:2008-05-01 00:00:00

  • Effect of cerebellar inactivation by lidocaine microdialysis on the vestibuloocular reflex in goldfish.

    abstract::Vestibuloocular reflex performance and adaptation were examined during vestibulocerebellar inactivation by localized lidocaine microdialysis or injection in goldfish. In the light, eye velocity perfectly compensated for head velocity (Vis-VOR) during sinusoidal yaw rotation (1/8 Hz +/- 20 degrees). In the dark, the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1286

    authors: McElligott JG,Beeton P,Polk J

    更新日期:1998-03-01 00:00:00

  • Enhanced Ih depresses rat entopeduncular nucleus neuronal activity from high-frequency stimulation or raised Ke+.

    abstract::High-frequency stimulation (HFS) is used to treat a variety of neurological diseases, yet its underlying therapeutic action is not fully elucidated. Previously, we reported that HFS-induced elevation in [K(+)](e) or bath perfusion of raised K(e)(+) depressed rat entopeduncular nucleus (EP) neuronal activity via an enh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01065.2007

    authors: Shin DS,Carlen PL

    更新日期:2008-05-01 00:00:00

  • Similar kinematic properties for ocular following and smooth pursuit eye movements.

    abstract::Ocular following (OFR) is a short-latency visual stabilization response to the optic flow experienced during self-motion. It has been proposed that it represents the early component of optokinetic nystagmus (OKN) and that it is functionally linked to the vestibularly driven stabilization reflex during translation (tra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01020.2004

    authors: Adeyemo B,Angelaki DE

    更新日期:2005-03-01 00:00:00

  • N-type voltage-dependent calcium channels mediate the nicotinic enhancement of GABA release in chick brain.

    abstract::The role of voltage-dependent calcium channels (VDCCs) in the nicotinic acetylcholine receptor (nAChR)-mediated enhancement of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) was investigated in chick brain slices. Whole cell recordings of neurons in the lateral spiriform (SpL) and ventral lateral genic...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.2.447

    authors: Tredway TL,Guo JZ,Chiappinelli VA

    更新日期:1999-02-01 00:00:00

  • Contribution of supragranular layers to sensory processing and plasticity in adult rat barrel cortex.

    abstract::Contribution of supragranular layers to sensory processing and plasticity in adult rat barrel cortex. J. Neurophysiol. 80: 3261-3271, 1998. In mature rat primary somatic sensory cortical area (SI) barrel field cortex, the thalamic-recipient granular layer IV neurons project especially densely to layers I, II, III, and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.6.3261

    authors: Huang W,Armstrong-James M,Rema V,Diamond ME,Ebner FF

    更新日期:1998-12-01 00:00:00

  • Multiple modes of action potential initiation and propagation in mitral cell primary dendrite.

    abstract::The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00057.2002

    authors: Chen WR,Shen GY,Shepherd GM,Hines ML,Midtgaard J

    更新日期:2002-11-01 00:00:00

  • Neuroplasticity induced by tooth pulp stimulation in trigeminal subnucleus oralis involves NMDA receptor mechanisms.

    abstract::We have recently demonstrated that application of the mustard oil (MO), a small-fiber excitant and inflammatory irritant, to the rat maxillary molar tooth pulp induces significant increases in jaw muscle electromyographic (EMG) activity and neuroplastic changes in trigeminal (V) subnucleus caudalis. Since subnucleus o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.5.1836

    authors: Park SJ,Chiang CY,Hu JW,Sessle BJ

    更新日期:2001-05-01 00:00:00

  • Diaphragm electromyographic activity following unilateral midcervical contusion injury in rats.

    abstract::Contusion-type injuries to the spinal cord are characterized by tissue loss and disruption of spinal pathways. Midcervical spinal cord injuries impair the function of respiratory muscles and may contribute to significant respiratory complications. This study systematically assessed the impact of a 100-kDy unilateral C...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00727.2016

    authors: Rana S,Sieck GC,Mantilla CB

    更新日期:2017-02-01 00:00:00

  • The two-dimensional spatial structure of simple receptive fields in cat striate cortex.

    abstract::1. A reverse correlation (6, 8, 25, 35) method is developed that allows quantitative determination of visual receptive-field structure in two spatial dimensions. This method is applied to simple cells in the cat striate cortex. 2. It is demonstrated that the reverse correlation method yields results with several desir...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.6.1187

    authors: Jones JP,Palmer LA

    更新日期:1987-12-01 00:00:00

  • Path perturbation detection tasks reduce MSTd neuronal self-movement heading responses.

    abstract::We presented optic flow and real movement heading stimuli while recording MSTd neuronal activity. Monkeys were alternately engaged in three tasks: visual detection of optic flow heading perturbations, vestibular detection of real movement heading perturbations, and auditory detection of brief tones. Push-button RTs we...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00958.2016

    authors: Page WK,Duffy CJ

    更新日期:2018-01-01 00:00:00

  • Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study.

    abstract::Using near-infrared spectroscopy (NIRS) and multichannel probes, we studied hemoglobin (Hb) concentration changes when single-pulse transcranial magnetic stimulation (TMS) was applied over the left hemisphere primary motor cortex (M1). Seventeen measurement probes were centered over left M1. Subjects were studied in b...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00980.2011

    authors: Furubayashi T,Mochizuki H,Terao Y,Arai N,Hanajima R,Hamada M,Matsumoto H,Nakatani-Enomoto S,Okabe S,Yugeta A,Inomata-Terada S,Ugawa Y

    更新日期:2013-03-01 00:00:00

  • Deep brain stimulation of the ventral striatal area for poststroke pain syndrome: a magnetoencephalography study.

    abstract::Poststroke pain syndrome (PSPS) is an often intractable disorder characterized by hemiparesis associated with unrelenting chronic pain. Although traditional analgesics have largely failed, integrative approaches targeting affective-cognitive spheres have started to show promise. Recently, we demonstrated that deep bra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00830.2017

    authors: Gopalakrishnan R,Burgess RC,Malone DA,Lempka SF,Gale JT,Floden DP,Baker KB,Machado AG

    更新日期:2018-06-01 00:00:00

  • Frequency organization of delay-sensitive neurons in the auditory cortex of the FM bat, Myotis lucifugus.

    abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.366

    authors: Paschal WG,Wong D

    更新日期:1994-07-01 00:00:00

  • Pattern of convergence of the receptors of the barnacle's three ocelli onto second-order cells.

    abstract::The giant barnacle, Balanus nubilus, has three simple eyes, two lateral and one median. We have studied the convergence of the receptors of these ocelli by recording from the second-order cell (I-cell) and from the receptors' terminals. The I-cell's responses to illumination of the median and lateral eyes are similar ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.55.5.882

    authors: Oland LA,Stuart AE

    更新日期:1986-05-01 00:00:00

  • Noninvasive brain stimulation can elucidate and interact with the mechanisms underlying motor learning and retention: implications for rehabilitation.

    abstract::Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor lear...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00766.2013

    authors: Hinder MR,Reissig P,Fujiyama H

    更新日期:2014-03-01 00:00:00

  • Enhancement of cortical plasticity by behavioral training in acetylcholine-depleted adult rats.

    abstract::Trimming all whiskers except two on one side of an adult rat's face results in cortical plasticity in which the spared whiskers, D2 and one D-row surround whisker (either D1 or D3), evoked responses containing more spikes than the response evoked by the cut whisker (called whisker pairing plasticity). Previously we ha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.4.1971

    authors: Sachdev RN,Egli M,Stonecypher M,Wiley RG,Ebner FF

    更新日期:2000-10-01 00:00:00

  • Tissue resistance changes and the profile of synchronized neuronal activity during ictal events in the low-calcium model of epilepsy.

    abstract::Population spikes vary in size during prolonged epileptic ("ictal") discharges, indicating variations in neuronal synchronization. Here we investigate the role of changes in tissue electrical resistivity in this process. We used the rat hippocampal slice, low-Ca(2+) model of epilepsy and measured changes in pyramidal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00123.2004

    authors: Fox JE,Bikson M,Jefferys JG

    更新日期:2004-07-01 00:00:00

  • Mixed slip-trip perturbation training for improving reactive responses in people with chronic stroke.

    abstract::This study determined the effect of mixed (slip- and trip-like stance perturbation) training on reactive responses in people with chronic stroke (PwCS) and examined modulation of their reactive responses on higher intensity perturbations posttraining (scaling). Twelve PwCS were exposed to consecutive blocks of treadmi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00671.2019

    authors: Dusane S,Bhatt T

    更新日期:2020-07-01 00:00:00

  • Preferential representation of instructed target location versus limb trajectory in dorsal premotor area.

    abstract::The dorsal premotor area (PMd) of monkeys has been implicated in processes relating to movement preparation and movement selection. In the present study, we sought to determine whether PMd neurons that are activated during a delayed reaching task have directional responses that reflect either the target (i.e., the goa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.3.1195

    authors: Shen L,Alexander GE

    更新日期:1997-03-01 00:00:00

  • Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain.

    abstract::The tail and paws in rodents are heat exchangers involved in the maintenance of core body temperature (T(core)). They are also the most widely used target organs to study acute or chronic "models" of pain. We describe the fluctuations of vasomotor tone in the tail and paws in conditions of thermal neutrality and the c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00721.2013

    authors: El Bitar N,Pollin B,Karroum E,Pincedé I,Mouraux A,Le Bars D

    更新日期:2014-11-01 00:00:00

  • SA1 and RA receptive fields, response variability, and population responses mapped with a probe array.

    abstract::Twenty-four slowly adapting type 1 (SA1) and 26 rapidly adapting (RA) cutaneous mechanoreceptive afferents in the rhesus monkey were studied with an array of independently controlled, punctate probes that covered an entire fingerpad. Each afferent had a receptive field (RF) on a single fingerpad and was studied at 73 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.6.2701

    authors: Vega-Bermudez F,Johnson KO

    更新日期:1999-06-01 00:00:00

  • Mechanisms underlying burst and regular spiking evoked by dendritic depolarization in layer 5 cortical pyramidal neurons.

    abstract::Apical dendrites of layer 5 pyramidal cells in a slice preparation of rat sensorimotor cortex were depolarized focally by long-lasting glutamate iontophoresis while recording intracellularly from their soma. In most cells the firing pattern evoked by the smallest dendritic depolarization that evoked spikes consisted o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.3.1341

    authors: Schwindt P,Crill W

    更新日期:1999-03-01 00:00:00

  • Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.

    abstract::Previous studies have demonstrated that locally administered cannabinoids attenuate allodynia and hyperalgesia through activation of peripheral cannabinoid receptors (CB(1) and CB(2)). However, it is currently unknown if cannabinoids alter the response properties of nociceptors. In the present study, correlative behav...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90809.2008

    authors: Potenzieri C,Brink TS,Pacharinsak C,Simone DA

    更新日期:2008-11-01 00:00:00

  • Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans.

    abstract::N-methyl-d-aspartate (NMDA) receptors play crucial roles in glutamate-mediated synaptic transmission and plasticity and are involved in a variety of brain functions. Specific single nucleotide polymorphisms (SNPs) in the genes encoding NMDA receptor subunits have been associated with some neuropsychiatric disorders in...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00318.2011

    authors: Mori F,Ribolsi M,Kusayanagi H,Siracusano A,Mantovani V,Marasco E,Bernardi G,Centonze D

    更新日期:2011-10-01 00:00:00

  • The dynamics of sensorimotor calibration in reaching-to-grasp movements.

    abstract::Reach-to-grasp movements require information about the distance and size of target objects. Calibration of this information could be achieved via feedback information (visual and/or haptic) regarding terminal accuracy when target objects are grasped. A number of reports suggest that the nervous system alters reach-to-...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00112.2013

    authors: Bingham GP,Mon-Williams MA

    更新日期:2013-12-01 00:00:00

  • Birdsong decreases protein levels of FoxP2, a molecule required for human speech.

    abstract::Cognitive and motor deficits associated with language and speech are seen in humans harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are thought to reside in structural abnormalities distributed across systems important for language and motor learning including the cerebral cortex, basal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90415.2008

    authors: Miller JE,Spiteri E,Condro MC,Dosumu-Johnson RT,Geschwind DH,White SA

    更新日期:2008-10-01 00:00:00

  • Robustness of muscle synergies underlying three-dimensional force generation at the hand in healthy humans.

    abstract::Previous studies using advanced matrix factorization techniques have shown that the coordination of human voluntary limb movements may be accomplished using combinations of a small number of intermuscular coordination patterns, or muscle synergies. However, the potential use of muscle synergies for isometric force gen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00173.2011

    authors: Roh J,Rymer WZ,Beer RF

    更新日期:2012-04-01 00:00:00

  • Modifications of locomotor pattern underlying escape behavior in the lamprey.

    abstract::Two forms of undulatory locomotion in the lamprey (a lower vertebrate) have been described earlier: fast forward swimming (FFS) used for long distance migrations and slow backward swimming (SBS) used for escape from adverse tactile stimuli. In the present study, we describe another form of escape behavior: slow forwar...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00903.2007

    authors: Islam SS,Zelenin PV

    更新日期:2008-01-01 00:00:00

  • Fatigue and motor redundancy: adaptive increase in finger force variance in multi-finger tasks.

    abstract::We studied the effects of fatigue of the index finger on indices of force variability in discrete and rhythmic accurate force production tasks performed by the index finger and by all four fingers pressing in parallel. An increase in the variance of the force produced by the fatigued index finger was expected. We hypo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00077.2010

    authors: Singh T,Varadhan SK,Zatsiorsky VM,Latash ML

    更新日期:2010-06-01 00:00:00