Enhanced Ih depresses rat entopeduncular nucleus neuronal activity from high-frequency stimulation or raised Ke+.

Abstract:

:High-frequency stimulation (HFS) is used to treat a variety of neurological diseases, yet its underlying therapeutic action is not fully elucidated. Previously, we reported that HFS-induced elevation in [K(+)](e) or bath perfusion of raised K(e)(+) depressed rat entopeduncular nucleus (EP) neuronal activity via an enhancement of an ionic conductance leading to marked depolarization. Herein, we show that the hyperpolarization-activated (I(h)) channel mediates the HFS- or K(+)-induced depression of EP neuronal activity. The perfusion of an I(h) channel inhibitor, 50 microM ZD7288 or 2 mM CsCl, increased input resistance by 23.5 +/- 7% (ZD7288) or 35 +/- 10% (CsCl), hyperpolarized cells by 3.4 +/- 1.7 mV (ZD7288) or 2.3 +/- 0.9 mV (CsCl), and decreased spontaneous action potential (AP) frequency by 51.5 +/- 12.5% (ZD7288) or 80 +/- 13.5% (CsCl). The I(h) sag was absent with either treatment, suggesting a block of I(h) channel activity. Inhibition of the I(h) channel prior to HFS or 6 mM K(+) perfusion not only prevented the previously observed decrease in AP frequency, but increased neuronal activity. Under voltage-clamp conditions, I(h) currents were enhanced in the presence of 6 mM K(+). Calcium is also involved in the depression of EP neuronal activity, since its removal during raised K(e)(+) application prevented this attenuation and blocked the I(h) sag. We conclude that the enhancement of I(h) channel activity initiates the HFS- and K(+)-induced depression of EP neuronal activity. This mechanism could underlie the inhibitory effects of HFS used in deep brain stimulation in output basal ganglia nuclei.

journal_name

J Neurophysiol

authors

Shin DS,Carlen PL

doi

10.1152/jn.01065.2007

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

2203-19

issue

5

eissn

0022-3077

issn

1522-1598

pii

01065.2007

journal_volume

99

pub_type

杂志文章
  • Interpreting the electrophysiological power spectrum.

    abstract::Recent experimental findings suggest that there may be rich physiological information embedded within the power spectrum of neurophysiological recordings, which, in addition to power in specific oscillatory frequencies, can be extracted with the appropriate model. This article reviews previous empirical and modeling r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00722.2015

    authors: Gao R

    更新日期:2016-02-01 00:00:00

  • Effects of occipital lobectomy upon eye movements in primate.

    abstract::1. Eye movements were recorded before and after bilateral occipital lobectomy in six rhesus monkeys trained to fixate and to follow small targets. Striate cortex was completely removed in two animals; small islands islands remained in the others. In all animals portions of extrastriate cortex were also removed but the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.4.883

    authors: Zee DS,Tusa RJ,Herdman SJ,Butler PH,Gücer G

    更新日期:1987-10-01 00:00:00

  • Heterogeneity of voltage- and chemosignal-activated response profiles in vomeronasal sensory neurons.

    abstract::Liolaemus lizards were explored to ascertain whether they would make an amenable model to study single-cell electrophysiology of neurons in the vomeronasal organ (VNO). Despite a rich array of chemosensory-related behaviors chronicled for this genus, no anatomical or functional data exist for the VNO, the organ mediat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00490.2005

    authors: Labra A,Brann JH,Fadool DA

    更新日期:2005-10-01 00:00:00

  • Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.

    abstract::Long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn may be relevant to pathological pain. Our previous work has shown that the late phase of the spinal LTP is protein synthesis-dependent. Considerable evidence has accumulated that dopamine D1/D5 receptors are important for late-phase ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01324.2004

    authors: Yang HW,Zhou LJ,Hu NW,Xin WJ,Liu XG

    更新日期:2005-08-01 00:00:00

  • Repetition suppression in monkey inferotemporal cortex: relation to behavioral priming.

    abstract::In tasks requiring judgments about visual stimuli, humans exhibit repetition priming, responding with increased speed when a stimulus is repeated. Repetition priming might depend on repetition suppression, a phenomenon first observed in monkey inferotemporal cortex (IT) whereby, when a stimulus is repeated, the streng...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01042.2006

    authors: McMahon DB,Olson CR

    更新日期:2007-05-01 00:00:00

  • Corticotrophin-releasing factor augments the I(H) in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro.

    abstract::The goal of this study was to characterize the effects of corticotrophin-releasing factor (CRF) on rat paraventricular nucleus (PVN) putative parvocellular neurons using whole cell patch-clamp recordings and single-cell reverse transcription-multiplex polymerase chain reaction (single-cell RT-mPCR) techniques. Under c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01325.2004

    authors: Qiu DL,Chu CP,Shirasaka T,Tsukino H,Nakao H,Kato K,Kunitake T,Katoh T,Kannan H

    更新日期:2005-07-01 00:00:00

  • Two intra-amygdaloid pathways to the central amygdala exhibit different mechanisms of long-term potentiation.

    abstract::Synaptic plasticity in the amygdala is thought to underlie aversive or rewarding learning and emotional memories. In this study, different mechanisms were found to underlie synaptic plasticity in lateral (LA) and basolateral (BLA) amygdala pathways to the primary output nucleus of the amygdala, the central amygdala (C...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00871.2004

    authors: Fu Y,Shinnick-Gallagher P

    更新日期:2005-05-01 00:00:00

  • Identification of two forebrain structures that mediate execution of memorized sequences in the pigeon.

    abstract::The execution of action sequences is the basis of most behavior. However, little is known about the neural foundation of visuomotor sequence execution in birds, although pigeons are a classic model animal to study sequence learning and production. Recently, we identified two structures in the pigeon brain, the nidopal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00763.2012

    authors: Helduser S,Cheng S,Güntürkün O

    更新日期:2013-02-01 00:00:00

  • Opposing mechanisms underlying differential changes in brain oxygen and temperature induced by intravenous morphine.

    abstract::Morphine remains widely used in clinical settings due to its potent analgesic properties. However, one of the gravest risks of all opioids is their ability to induce respiratory depression and subsequent brain hypoxia that can lead to coma and death. Due to these life-threatening effects, our goal was to examine the e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00445.2018

    authors: Solis E Jr,Afzal A,Kiyatkin EA

    更新日期:2018-11-01 00:00:00

  • Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampus.

    abstract::In the hippocampus, the calcium-binding protein parvalbumin (PV) is expressed in interneurons that innervate perisomatic regions. PV in GABAergic synaptic terminals was proposed to limit repetitive GABA release by buffering of "residual calcium." We assessed the role of presynaptic PV in Ca(2+)-dependent GABA release ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00576.2002

    authors: Vreugdenhil M,Jefferys JG,Celio MR,Schwaller B

    更新日期:2003-03-01 00:00:00

  • Quantifying the spatial extent of the corollary discharge benefit to transsaccadic visual perception.

    abstract::Extraretinal information, such as corollary discharge (CD), is hypothesized to help compensate for saccade-induced visual input disruptions. However, support for this hypothesis is largely for one-dimensional transsaccadic visual changes, with little comprehensive information on the spatial characteristics. Here we sy...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00657.2015

    authors: Jayet Bray LC,Bansal S,Joiner WM

    更新日期:2016-03-01 00:00:00

  • Mechanosensitive potassium channels in rat colon sensory neurons.

    abstract::Single-channel recording techniques were used to characterize mechanosensitive channels in identified (1.1'-dioctadecyl-3,3,3', 3'-tetramethylindocarbocyanine methanesulfonate labeled) colon sensory neurons dissociated from adult S1 dorsal root ganglia. Channels were found in 30% (7/23) of patches in a cell-attached c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.2.836

    authors: Su X,Wachtel RE,Gebhart GF

    更新日期:2000-08-01 00:00:00

  • Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients.

    abstract::Facial flushing in rosacea is often induced by trigger events. However, trigger causation mechanisms are currently unclear. This study tested the central hypothesis that rosacea causes sympathetic and axon reflex-mediated alterations resulting in trigger-induced symptomatology. Twenty rosacea patients and age/sex-matc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00458.2015

    authors: Metzler-Wilson K,Toma K,Sammons DL,Mann S,Jurovcik AJ,Demidova O,Wilson TE

    更新日期:2015-09-01 00:00:00

  • Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain.

    abstract::The tail and paws in rodents are heat exchangers involved in the maintenance of core body temperature (T(core)). They are also the most widely used target organs to study acute or chronic "models" of pain. We describe the fluctuations of vasomotor tone in the tail and paws in conditions of thermal neutrality and the c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00721.2013

    authors: El Bitar N,Pollin B,Karroum E,Pincedé I,Mouraux A,Le Bars D

    更新日期:2014-11-01 00:00:00

  • Two neuropeptides colocalized in a command-like neuron use distinct mechanisms to enhance its fast synaptic connection.

    abstract::In many neurons more than one peptide is colocalized with a classical neurotransmitter. The functional consequence of such an arrangement has been rarely investigated. Here, within the feeding circuit of Aplysia, we investigate at a single synapse the actions of two modulatory neuropeptides that are present in a choli...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00358.2003

    authors: Koh HY,Vilim FS,Jing J,Weiss KR

    更新日期:2003-09-01 00:00:00

  • Physiology of neuronal subtypes in the respiratory-vocal integration nucleus retroamigualis of the male zebra finch.

    abstract::Learned vocalizations, such as bird song, require intricate coordination of vocal and respiratory muscles. Although the neural basis for this coordination remains poorly understood, it likely includes direct synaptic interactions between respiratory premotor neurons and vocal motor neurons. In birds, as in mammals, th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00257.2005

    authors: Kubke MF,Yazaki-Sugiyama Y,Mooney R,Wild JM

    更新日期:2005-10-01 00:00:00

  • Developmental alteration of endocannabinoid retrograde signaling in the hippocampus.

    abstract::Endocannabinoids are lipid derivatives that mediate paracrine and juxtacrine signaling between cells. In the hippocampal CA1 region, a retrograde endocannabinoid signal suppresses GABA release by acting on presynaptic cannabinoid receptor-1 (CB1) and can be functionally manifested as depolarization-induced suppression...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00327.2009

    authors: Zhu PJ,Lovinger DM

    更新日期:2010-02-01 00:00:00

  • Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem.

    abstract::Cardiovascular function is regulated by a dynamic balance composed of sympathetic and parasympathetic activity. Sympathoexcitatory presympathetic neurons (PSNs) in the rostral ventrolateral medulla project directly to cardiac and vasomotor sympathetic preganglionic neurons in the spinal cord. In proximity to the PSNs ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01054.2012

    authors: Dergacheva O,Boychuk CR,Mendelowitz D

    更新日期:2013-08-01 00:00:00

  • Two-dimensional saccade-related population activity in superior colliculus in monkey.

    abstract::The two-dimensional distribution of population activity in the superior colliculus (SC) during saccadic eye movements in the monkey was estimated using radial basis functions. To make these ensemble activity estimates, cells in the deeper layers of the SC were recorded over much of the rostrocaudal (caudal to 3.8 mm f...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.2.798

    authors: Anderson RW,Keller EL,Gandhi NJ,Das S

    更新日期:1998-08-01 00:00:00

  • Fictive rhythmic motor patterns induced by NMDA in an in vitro brain stem-spinal cord preparation from an adult urodele.

    abstract::An in vitro brain stem-spinal cord preparation from an adult urodele (Pleurodeles waltl) was developed in which two fictive rhythmic motor patterns were evoked by bath application of N-methyl-D-aspartate (NMDA; 2.5-10 microM) with D-serine (10 microM). Both motor patterns displayed left-right alternation. The first pa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.2.1074

    authors: Delvolvé I,Branchereau P,Dubuc R,Cabelguen JM

    更新日期:1999-08-01 00:00:00

  • Superior colliculus signals decisions rather than confidence: analysis of single neurons.

    abstract::Recent findings indicate that monkeys can report their confidence in perceptual decisions and that this information is encoded in neurons involved in making decisions, including the lateral intraparietal area (LIP) and the supplementary eye field (SEF). A key issue to consider when studying confidence is that decision...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00152.2018

    authors: Grimaldi P,Cho SH,Lau H,Basso MA

    更新日期:2018-11-01 00:00:00

  • Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition.

    abstract::N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia patients, reduces ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00809.2012

    authors: Bolton AD,Phillips MA,Constantine-Paton M

    更新日期:2013-10-01 00:00:00

  • Prestimulus hemodynamic activity in dorsal attention network is negatively associated with decision confidence in visual perception.

    abstract::Attention is thought to improve most aspects of perception. However, we recently showed that, somewhat surprisingly, endogenous attention can also lead to low subjective perceptual ratings (Rahnev et al., 2011). Here we investigated the neural basis of this effect and tested whether spontaneous fluctuations of the att...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00184.2012

    authors: Rahnev DA,Bahdo L,de Lange FP,Lau H

    更新日期:2012-09-01 00:00:00

  • Sound-level-dependent representation of frequency modulations in human auditory cortex: a low-noise fMRI study.

    abstract::Recognition of sound patterns must be largely independent of level and of masking or jamming background sounds. Auditory patterns of relevance in numerous environmental sounds, species-specific vocalizations and speech are frequency modulations (FM). Level-dependent activation of the human auditory cortex (AC) in resp...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00187.2001

    authors: Brechmann A,Baumgart F,Scheich H

    更新日期:2002-01-01 00:00:00

  • Cholinergic modulation of synaptic inhibition in the guinea pig hippocampus in vitro: excitation of GABAergic interneurons and inhibition of GABA-release.

    abstract::1. The effect of cholinergic receptor activation on gamma-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission was investigated in voltage-clamped CA1 pyramidal neurons (HPNs) in the guinea pig hippocampal slice preparation. 2. The cholinergic agonist carbachol (1-10 microM) induced a prominent and susta...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.2.626

    authors: Behrends JC,ten Bruggencate G

    更新日期:1993-02-01 00:00:00

  • Tactile sensory coding during development: signaling capacities of neurons in kitten dorsal column nuclei.

    abstract::The functional maturation of cuneate neurons was studied using reproducible tactile stimulation procedures and quantitative assessment of coding capacities in anesthetized (N2O/O2 plus barbiturate infusion) or decerebrate cats from six different age groups; neonatal (1-5 days), 10-15, 25-30, 55-63, and 83-90 days, and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.52.1.86

    authors: Connor KM,Ferrington DG,Rowe MJ

    更新日期:1984-07-01 00:00:00

  • Structural modularity and grid activity in the medial entorhinal cortex.

    abstract::Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question. Fundamental similarities in micro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00574.2017

    authors: Naumann RK,Preston-Ferrer P,Brecht M,Burgalossi A

    更新日期:2018-06-01 00:00:00

  • Activation of a lobster motor rhythm-generating network by disinhibition of permissive modulatory inputs.

    abstract::Rhythm generation by the gastric motor network in the stomatogastric ganglion (STG) of the lobster Homarus gammarus is controlled by modulatory projection neurons from rostral commissural ganglia (CoGs); blocking action potential conduction in these inputs to the STG of a stomatogastric nervous system in vitro rapidly...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.5.2776

    authors: Faumont S,Simmers J,Meyrand P

    更新日期:1998-11-01 00:00:00

  • Swimming rhythm generation in the caudal hindbrain of the lamprey.

    abstract::The spinal cord has been well established as the site of generation of the locomotor rhythm in vertebrates, but studies have suggested that the caudal hindbrain in larval fish and amphibians can also generate locomotor rhythms. Here, we investigated whether the caudal hindbrain of the adult lamprey ( Petromyzon marinu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00851.2017

    authors: Buchanan JT

    更新日期:2018-05-01 00:00:00

  • Remapping in human visual cortex.

    abstract::With each eye movement, stationary objects in the world change position on the retina, yet we perceive the world as stable. Spatial updating, or remapping, is one neural mechanism by which the brain compensates for shifts in the retinal image caused by voluntary eye movements. Remapping of a visual representation is b...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00189.2006

    authors: Merriam EP,Genovese CR,Colby CL

    更新日期:2007-02-01 00:00:00