First-order elimination kinetics following baclofen overdose.

Abstract:

:We followed serial plasma baclofen concentrations in a woman who ingested more than 2 g of baclofen in a suicide attempt, the largest ingestion of baclofen reported to date. The plasma clearance of baclofen was characterized by first-order elimination kinetics with a half-life of 8.6 hours. The persistent central nervous system depression noted in our patient after the return of plasma baclofen levels to the therapeutic range is best explained by delayed clearance of baclofen from the CNS. She made a full recovery with supportive care. No evidence of saturable elimination kinetics was found.

journal_name

Ann Emerg Med

authors

Gerkin R,Curry SC,Vance MV,Sankowski PW,Meinhart RD

doi

10.1016/s0196-0644(86)80388-2

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

843-6

issue

7

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(86)80388-2

journal_volume

15

pub_type

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