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Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.

Abstract：

:Twenty-four evaluable patients with epithelial ovarian cancer resistant to primary therapy, or relapsing after response to initial therapy, were treated with acivicin utilizing a daily X 5 schedule. One patient achieved a partial response lasting five months; the remaining 23 patients showed no objective response. Profound and dose-limiting neurological toxicity was seen in 11 patients. Acivicin is inactive in patients with previously treated ovarian cancer and has a poor therapeutic index due to neurologic adverse effects in this patient population. The profound neurotoxicity may be related to prior therapy with cisplatin, to protein binding in ascitic fluid accumulations or to yet undefined parameters.

journal_name

Invest New Drugs

journal_title

Investigational new drugs

authors

McGuire WP,Blessing JA,DiSaia PJ,Buchsbaum HJ

doi

10.1007/BF00172016

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

49-52

issue

1

eissn

0167-6997

issn

1573-0646

journal_volume

4

pub_type

杂志文章

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