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Phase II trial of low-dose N-(phosphonacetyl)-disodium L-aspartic acid and high-dose 24-hour infusional 5-fluorouracil in advanced gastric adenocarcinoma. A Southwest Oncology Group study.

Abstract：

:N-(phosphonacetyl)-disodium L-aspartic acid (PALA) demonstrates a synergistic antitumor effect when combined with 5-Fluorouracil (5-FU) in in vitro studies. In a Phase II trial, 23 eligible patients with unresectable or metastatic adenocarcinoma of the stomach were treated with weekly i.v. bolus PALA (250 mg/M2) followed 24 hours later by a 24-hour infusion of 5-FU (2600 mg/M2) for an initial period of 8 weeks. No objective responses were noted. PALA and 5-FU is inactive against gastric adenocarcinoma at the doses and schedule used in this trial.

journal_name

Invest New Drugs

journal_title

Investigational new drugs

authors

Martino RL,Fleming TR,Morrell LM,Ardalan B,Richman SP,Macdonald JS

doi

10.1007/BF00180821

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

419-21

issue

4

eissn

0167-6997

issn

1573-0646

journal_volume

14

pub_type

临床试验,杂志文章

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