Pigment gallstones form as a composite of bacterial microcolonies and pigment solids.

Abstract:

:Although previous studies have suggested that bacteria may contribute to pigment gallstone formation, the current experiments provide evidence that bacteria have a central role in this process. The studies included scanning electron microscopy (SEM) of gallstones, measurements of bacterial adherence to gallstones in vitro, and determination of glycocalyx elaboration by biliary bacteria. Gallstones from 85 patients were studied under SEM. Twenty-five (78%) of 32 pigment stones had evidence of bacterial microcolonies throughout the interior of the stones. Bacteria were absent from the interior of all 35 cholesterol stones studied. Composite stones (stones with separate pigment and cholesterol portions) showed evidence of bacteria within the pigment portions in 14 (78%) of 18 cases. Biliary bacteria adhered to the surface of pigment gallstones in vitro in 35 (90%) of 39 cases, compared with three (8%) of 39 cholesterol stones. Glycocalyx was elaborated by bacteria isolated from nine (82%) of 11 patients with either pigment or composite gallstones. One (33%) of three bacterial species from patients with cholesterol gallstone disease produced glycocalyx. These studies indicate that most pigment gallstones obtained from patients in Western cultures form as a composite of bacteria, bacterial glycocalyx, and pigment solids. Bacteria were found in the majority of black as well as brown pigment stones. These findings serve as the basis of a new theory of pigment stone formation in which bacteria and glycocalyx are postulated to be responsible for the precipitation and subsequent agglomeration of bilirubin pigment. These results also suggest that sepsis is more common in pigment gallstone disease because the stones can serve as a sanctuary for bacteria.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Stewart L,Smith AL,Pellegrini CA,Motson RW,Way LW

doi

10.1097/00000658-198709000-00002

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

242-50

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

206

pub_type

杂志文章
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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.sla.0000124298.74199.e5

    authors: Demetriou AA,Brown RS Jr,Busuttil RW,Fair J,McGuire BM,Rosenthal P,Am Esch JS 2nd,Lerut J,Nyberg SL,Salizzoni M,Fagan EA,de Hemptinne B,Broelsch CE,Muraca M,Salmeron JM,Rabkin JM,Metselaar HJ,Pratt D,De La Mata M,Mc

    更新日期:2004-05-01 00:00:00

  • Endoscopic harvesting device type and outcomes in patients undergoing coronary artery bypass surgery.

    abstract:OBJECTIVE:To evaluate angiographic and clinical outcomes associated with open and closed dissection tunnel endoscopic vein harvesting (EVH) devices. BACKGROUND:A previous PREVENT-IV (PRoject of Ex-vivo Vein graft ENgineering via Transfection IV) analysis reported that EVH for coronary artery bypass graft surgery was a...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000377

    authors: van Diepen S,Brennan JM,Hafley GE,Reyes EM,Allen KB,Ferguson TB,Peterson ED,Williams JB,Gibson CM,Mack MJ,Kouchoukos NT,Alexander JH,Lopes RD

    更新日期:2014-08-01 00:00:00

  • A Study of Clinical Coding Accuracy in Surgery: Implications for the Use of Administrative Big Data for Outcomes Management.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000851

    authors: Nouraei SA,Hudovsky A,Frampton AE,Mufti U,White NB,Wathen CG,Sandhu GS,Darzi A

    更新日期:2015-06-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200008000-00011

    authors: Orozco H,Mercado MA,Chan C,Guillén-Navarro E,López-Martínez LM

    更新日期:2000-08-01 00:00:00

  • The Linton splenorenal shunt in the management of the bleeding complications of portal hypertension.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198212001-00008

    authors: Ottinger LW

    更新日期:1982-12-01 00:00:00

  • Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases.

    abstract:OBJECTIVE:To determine overall survival and disease-free survival in selected patients with nonresectable liver-only colorectal cancer receiving liver transplantation. BACKGROUND:Patients with nonresectable colorectal cancer receiving palliative chemotherapy has a 5-year overall survival of about 10%. Liver transplant...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003404

    authors: Dueland S,Syversveen T,Solheim JM,Solberg S,Grut H,Bjørnbeth BA,Hagness M,Line PD

    更新日期:2020-02-01 00:00:00

  • Middle aortic syndrome. Effectiveness and durability of complex arterial revascularization techniques.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198609000-00012

    authors: Messina LM,Reilly LM,Goldstone J,Ehrenfeld WK,Ferrell LD,Stoney RJ

    更新日期:1986-09-01 00:00:00

  • Incidence and outcome of biliary strictures after pancreaticoduodenectomy.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000216285.07069.fc

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    更新日期:2006-05-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000482

    authors: Talsma AK,Lingsma HF,Steyerberg EW,Wijnhoven BP,Van Lanschot JJ

    更新日期:2014-08-01 00:00:00

  • Microwave ablation for hepatic malignancies: a multiinstitutional analysis.

    abstract:OBJECTIVE:This study hypothesized that tumor size, number of tumors, surgical approach, and tumor histology significantly affected microwave ablation (MWA) success and recurrence-free survival. BACKGROUND:Although many hepatobiliary centers have adopted MWA, the factors that influence local control are not well descri...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000234

    authors: Groeschl RT,Pilgrim CH,Hanna EM,Simo KA,Swan RZ,Sindram D,Martinie JB,Iannitti DA,Bloomston M,Schmidt C,Khabiri H,Shirley LA,Martin RC,Tsai S,Turaga KK,Christians KK,Rilling WS,Gamblin TC

    更新日期:2014-06-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318248bdb5

    authors: Graat LJ,Bosma E,Roukema JA,Heisterkamp J

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197908000-00009

    authors: Funch-Jensen P,Csendes A,Kruse A,Oster MJ,Amdrup E

    更新日期:1979-08-01 00:00:00

  • Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003094

    authors: O'Donnell TFX,Boitano LT,Deery SE,Schermerhorn ML,Schanzer A,Beck AW,Green RM,Takayama H,Patel VI

    更新日期:2020-05-01 00:00:00

  • Readmission after colectomy for cancer predicts one-year mortality.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181d3d27c

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    更新日期:2010-04-01 00:00:00

  • Comparison of four provocative tests for the diagnosis of gastrinoma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198305000-00015

    authors: Romanus ME,Neal JA,Dilley WG,Leight GS,Linehan WM,Santen RJ,Farndon JR,Jones RS,Wells SA Jr

    更新日期:1983-05-01 00:00:00

  • Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trial.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200210000-00004

    authors: Tran K,Van Eijck C,Di Carlo V,Hop WC,Zerbi A,Balzano G,Jeekel H

    更新日期:2002-10-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197807000-00012

    authors: Lobe TE,Martin EW Jr,Cooperman M,Vasko J,Evans WE

    更新日期:1978-07-01 00:00:00

  • Preoperative and long-term cardiac risk assessment. Predictive value of 23 clinical descriptors, 7 multivariate scoring systems, and quantitative dipyridamole imaging in 360 patients.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199208000-00010

    authors: Lette J,Waters D,Bernier H,Champagne P,Lassonde J,Picard M,Cerino M,Nattel S,Boucher Y,Heyen F

    更新日期:1992-08-01 00:00:00

  • Gastric carcinoma following operation for peptic ulcer disease.

    abstract::Gastric carcinoma following operation for benign peptic ulcer disease has been considered rare but nine patients have been seen during the past five years. All were male patients, the average time interval from prior ulcer operation to development of cancer was 17 years, but was a short as ten years. The symptoms of c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197803000-00007

    authors: Eberlein TJ,Lorenzo FV,Webster MW

    更新日期:1978-03-01 00:00:00

  • "Keyhole" coronary artery bypass surgery.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199610000-00004

    authors: Landreneau RJ,Mack MJ,Magovern JA,Acuff TA,Benckart DH,Sakert TA,Fetterman LS,Griffith BP

    更新日期:1996-10-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197609000-00010

    authors: Paulson DL,Reisch JS

    更新日期:1976-09-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826578fb

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    更新日期:2012-09-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199708000-00008

    authors: Law S,Fok M,Chu KM,Wong J

    更新日期:1997-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-200202000-00008

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198705000-00015

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    更新日期:2008-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-197902000-00016

    authors: Moss GS,Das Gupta TK,Brinkman R,Sehgal L,Newsom B

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    pub_type: 杂志文章

    doi:10.1097/00000658-197409000-00008

    authors: McDermott WV Jr,Hensle TW

    更新日期:1974-09-01 00:00:00

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    doi:10.1097/00000658-197809000-00013

    authors: Wells SA Jr,Baylin SB,Gann DS,Farrell RE,Dilley WG,Preissig SH,Linehan WM,Cooper CW

    更新日期:1978-09-01 00:00:00