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Iron-dependent oxidative stress as a pathogenesis for preterm birth.

Abstract：

PROBLEM:Preterm birth (PTB) is an oxidative stress-related disease that lacks effective therapies partly because of the poor understanding of disease pathogenesis. The aim of this manuscript was to review molecular pathways that could be responsible for the pathogenesis of PTB. Genomic and proteomic studies have started to delineate the wide array of mediators involved in this disorder. Understanding the mechanisms of the development of PTB and elucidating pathogenesis and pathophysiology are intrinsic to prevention and effective therapies for this disorder. METHOD OF STUDY:This article reviews the English language literature for pathogenesis and pathophysiological studies on PTB. Several recent genomic and proteomic studies are discussed in the context of PTB biology. RESULTS:Decidual hemorrhage has been identified histologically in the placentas of patients with PTB, which may result in high levels of free heme and iron. Several important PTB-specific genes and proteins overlap with those known to be regulated by iron. Others were genes involved in oxidative stress and detoxification. Free iron oxidatively modifies lipid and protein, leading to DNA and cell damage. This signaling pathway of PTB will be discussed as it provides new insights into regulation of inflammation, oxidative stress, and detoxification. CONCLUSION:This review summarizes recent advances in heme/iron-mediated signaling, the target genes thereof, and the potential challenges to the understanding of pathogenesis and pathophysiology of PTB. A novel model is proposed. Collectively, decidual hemorrhage and inflammation are considered to be major contributors to the pathogenesis of PTB. TARGET AUDIENCE:Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES:After completion of this article, the reader should be able to paraphrase the role of oxidative stress in pathogenesis of preterm birth, explain the idea of preterm birth as a "syndrome," and summarize the potential role of early uterine bleeding in pathophysiology of preterm birth.

journal_name

Obstet Gynecol Surv

journal_title

Obstetrical & gynecological survey

authors

Sakata M,Sado T,Kitanaka T,Naruse K,Noguchi T,Yoshida S,Shigetomi H,Onogi A,Oi H,Kobayashi H

doi

10.1097/OGX.0b013e318181a79f

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

651-60

issue

eissn

0029-7828

issn

1533-9866

pii

0006254-200810000-00021

journal_volume

pub_type

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Iron-dependent oxidative stress as a pathogenesis for preterm birth.