Abstract:
UNLABELLED:Our objective was to assess current knowledge regarding PAPNET (Neuromedical Systems, Inc.) automated cervical cytology screening methods and to assess the performance of this automated system in comparison with manual screening. To this goal, studies published in the English language regarding the PAPNET system, identified from a MEDLINE search through August 1998 were selected. Performance of the PAPNET system was assessed with various meta-analysis techniques, using the method of Mantel-Haenszel. In the primary screening modality, meta-analysis of the performance of the PAPNET system indicates that when compared with manual screening, the odds of obtaining a positive result were significantly greater. The Mantel-Haenszel odds ratio for combined studies was 1.19 (95 percent CI = 1.13 to 1.26, P < .001), corresponding to 20 percent greater odds of positive or suspicious slides with PAPNET system. The PAPNET system performs with almost two-fold less false-negative results. The Mantel-Haenszel odds ratio for combined studies was 0.41 (95 percent CI = 0.25 to 0.67, P < .005). Applied as a quality control modality rescreening all consecutive previously manually screened negative slides, depending on study design, the PAPNET system reclassified as abnormal between 0.1 and 5 percent. However, when the PAPNET system was used to rescreen known false-negative slides, PAPNET system rescreening can correctly identify between 20 and 90 percent of manually screened false-negative slides with an average reduction of 33 percent of the manually screened false-negative slides. We conclude that compared with manual screening, PAPNET identifies 20 percent more abnormal, has two-fold less false-negative, and reclassifies as abnormal one third of manually screened false-negative slides. TARGET AUDIENCE:Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES:After completion of this article, the reader will be able to understand how the PAPNET system works and what is its approved use by the FDA, and to understand the associated benefits and shortcomings of the PAPNET system when compared with the traditional screening method.
journal_name
Obstet Gynecol Survjournal_title
Obstetrical & gynecological surveyauthors
Abulafia O,Sherer DMdoi
10.1097/00006254-199904000-00022subject
Has Abstractpub_date
1999-04-01 00:00:00pages
253-64issue
4eissn
0029-7828issn
1533-9866journal_volume
54pub_type
杂志文章,meta分析abstract:UNLABELLED:Depression is common in reproductive age women, and continued pharmacologic treatment of depression during pregnancy may be necessary to prevent relapse, which could be harmful for both the fetus and the mother. Although data on drug safety are imperfect and incomplete, the benefits of antidepressant therapy...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e3181676be8
更新日期:2008-04-01 00:00:00
abstract:UNLABELLED:Human reproduction provides unique opportunities for the transmission of infectious agents. Furthermore, the mother and her offspring have distinct susceptibilities to infection at each stage of reproduction, from conception and gestation to parturition and the neonatal period. The impact of pathogens on rep...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e3181c9e7a1
更新日期:2010-01-01 00:00:00
abstract:UNLABELLED:Imbalances in bone metabolism result in bone mass loss and skeletal fragility in postmenopausal women and older men. Most osteoporosis treatments decrease bone metabolism and prevent the progression of bone loss and architectural damage to the skeleton. Analogs of parathyroid hormone stimulate the formation ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.ogx.0000146584.12831.c9
更新日期:2004-12-01 00:00:00
abstract::The objective of this review is to estimate the risk of severe thrombocytopenia at birth and minor or major morbidity for the infant of a pregnancy complicated by immune thrombocytopenic purpura. English language publications on immune thrombocytopenic purpura in pregnancy from January 1980 to December 1990 were used....
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199312000-00003
更新日期:1993-12-01 00:00:00
abstract::This review first makes some general comments about prophylactic antibiotics: animal models for antimicrobial prophylaxis, bacterial flora of the female genital tract, timing and duration of prophylactic antibiotic administration, and drug of choice for prophylaxis. Subsequent sections cover the following: prophyla...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-198409000-00001
更新日期:1984-09-01 00:00:00
abstract:UNLABELLED:Thromboembolism in pregnancy is a major contributor to pregnancy morbidity and mortality with potentially serious adverse effects for both mother and fetus. The purposes of this article are to explore the impact of heritable and acquired thrombophilias on pregnancy and to determine the appropriateness of scr...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.ogx.0000165116.96026.4e
更新日期:2005-06-01 00:00:00
abstract::Maternal hemodynamic adaptation to pregnancy consists of profound changes in various interdependent systems. Of crucial importance in the early adaptation of the volume homeostatic mechanisms to pregnancy is the resetting of the volume and osmoreceptors. This resetting may be induced by a reduction in vascular tone an...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199412000-00007
更新日期:1994-12-01 00:00:00
abstract:UNLABELLED:The year 2007 marks the fifteenth anniversary year of the founding of a landmark effort in drug safety risk management, the formation of the first monitoring effort of an antiretroviral (ARV) drug in pregnancy which has become the Antiretrovirals in Pregnancy Registry, the APR. This multicompany, multi-natio...
journal_title:Obstetrical & gynecological survey
pub_type: 历史文章,杂志文章
doi:10.1097/01.ogx.0000253377.14647.80
更新日期:2007-02-01 00:00:00
abstract::Obstetrician/gynecologists are taking on more primary care responsibilities and thus are expected to have a wider base of medical knowledge on a variety of women's health issues. The Collaborative Ambulatory Research Network (CARN) was created in 1990 to investigate issues pertinent to women's health and to the practi...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/01.ogx.0000143775.07827.bb
更新日期:2004-11-01 00:00:00
abstract:UNLABELLED:This review aims to summarize existing information concerning visual disturbances in (pre) eclampsia that have been described in the literature. Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality worldwide. Visual disturbances in (pre)eclampsia seem to be frequent phenome...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e318250a457
更新日期:2012-04-01 00:00:00
abstract::The various phenomena of toxemia of pregnancy both in primiparous and multiparous women may be explained by postulating a defect in the calcium transport mechanism, both in the smooth muscle of the uterus and vascular smooth muscle as well as a similar defect in platelets. The involvement of prostaglandin E has not be...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/00006254-198005000-00028
更新日期:1980-05-01 00:00:00
abstract::Metformin is a common treatment for women who have insulin resistance manifesting as type 2 diabetes or polycystic ovarian syndrome (PCOS). With an increasing number of these patients conceiving, it is expected that the use of metformin in and around the time of pregnancy will increase. This article reassesses the mec...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.OGX.0000109224.52893.B8
更新日期:2004-02-01 00:00:00
abstract:Importance:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women. Women with PCOS are at increased risk of developing several metabolic and reproductive abnormalities, including metabolic syndrome. Underlying the combined metabolic and reproductive dysfunction is lipotoxicity, de...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/OGX.0000000000000661
更新日期:2019-04-01 00:00:00
abstract:UNLABELLED:To assess the impact of dengue infection during pregnancy on birth outcomes, we conducted a systematic review of 30 published studies (19 case reports, 9 case series, and 2 comparison studies). Studies were identified by searching computerized databases using dengue and dengue hemorrhagic fever, cross-refere...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e3181cb8fbc
更新日期:2010-02-01 00:00:00
abstract:Importance:Real-time electrohysterography (EHG)-based technologies have recently become available for uterine monitoring during term labor. Therefore, obstetricians need to be familiar with the diagnostic value, advantages, and limitations of using EHG. Objective:The aims of this study were to determine the diagnostic...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000560
更新日期:2018-05-01 00:00:00
abstract:Importance:Women with a history of preeclampsia have a 2- to 5-fold increased risk of cardiovascular diseases, which represent almost half of mortality in the female population worldwide. Objective:To summarize the current evidence concerning women's future cardiovascular risk after pregnancies complicated by preeclam...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/OGX.0000000000000846
更新日期:2020-11-01 00:00:00
abstract::Historically, hysterectomy is one of the oldest gynecologic operations, dating back to the 1840s. Currently, it is the most common gynecologic operation performed and is associated with marked improvement in the patients' quality of life. It is widely considered a safe procedure with an extremely low mortality rate (<...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.ogx.0000120166.84206.dd
更新日期:2004-04-01 00:00:00
abstract::Approximately one in four women will experience a miscarriage during her lifetime. For more than 50 years, the standard management of early pregnancy failure has been a dilatation and curettage (D & C). Typically, the procedure is performed in an operating room, which significantly increases cost. There is little obje...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200102000-00024
更新日期:2001-02-01 00:00:00
abstract::Mature cystic teratomas (MCT), commonly called dermoid cysts, are the most common benign germ cell tumors of the ovary in women of reproductive age. Future fertility is of major concern among these women; therefore, the surgical management must focus on preserving ovarian tissue and minimizing adhesion formation. Pati...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200012000-00004
更新日期:2000-12-01 00:00:00
abstract::The use of blood products has come under closer scrutiny over the past decade because of the autoimmune deficiency syndrome. Newer technology has led to the use of component therapy in most situations. The use of fresh-frozen plasma has been overstated in the older literature, and fresh-frozen plasma should be used in...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199105000-00015
更新日期:1991-05-01 00:00:00
abstract::The use of an extraamniotic catheter balloon, inflated above the internal cervical os, has been advocated as a nonpharmacological, mechanical method of cervical ripening before induction of labor. Additional measures may include applying traction on the catheter, or the infusion of normal saline (1 ml/min) via the cat...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199610000-00022
更新日期:1996-10-01 00:00:00
abstract::Porencephaly may result from either a developmental anomaly or an antepartum intraparenchymal insult. Pre- and postnatal ultrasonography can demonstrate characteristic images of porencephaly. There is minimal literature on diagnosis and outcome of antenatally diagnosed porencephaly. There are two types of porencephaly...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199509000-00023
更新日期:1995-09-01 00:00:00
abstract:Importance:Globally, more than 125 million women each year are at risk of malaria during pregnancy. Endemic regions carry the greatest burden; however, with globalization, providers in nonendemic regions are encountering increasing numbers of women exposed to or infected with malaria. Objectives:The aim of this articl...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000704
更新日期:2019-09-01 00:00:00
abstract::This article reviews the literature that evaluates pruritic urticarial papules and plaques of pregnancy, herpes gestationis, and intrahepatic cholestasis of pregnancy and their impact on the fetus. Using MEDLINE years 1966 to 1999, a literature search was performed using the terms pregnancy, dermatology, pruritic urti...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200107000-00022
更新日期:2001-07-01 00:00:00
abstract::Brain abscess is a potentially life-threatening complication that is only rarely associated with pregnancy. Although predispositions such as a preexisting infection, foreign body, or immunosuppression are often present, up to 30% of individuals could have no risk factors. Presenting symptoms are often nonspecific but ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.ogx.0000115861.54002.8b
更新日期:2004-03-01 00:00:00
abstract::A variegated group of autoimmune disorders tend to occur in women during childbearing years. Autoantibodies, often of IgG type, directed against the mother's (self) antigens has been well characterized in a number of these disorders. Transplacental transfer of IgG autoantibodies has been frequently demonstrated withou...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
abstract::Oxytocin, elevated estrogen-progesterone ratio, fetal corticosteroids, prostaglandins, catecholamines, and changes in uterine blood flow have all been implicated as triggers of labor. In approximately one-third of cases of threatened premature labor contractions stop spontaneously. Thus placebo-controlled randomized t...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/00006254-197808000-00001
更新日期:1978-08-01 00:00:00
abstract::The purpose of this review is to provide the obstetrician/gynecologist with a comprehensive review of the open Burch procedure including operative technique and modifications, complications, and success rates. A computerized search of English-language articles was performed on the MEDLINE database. Additional sources ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199901000-00024
更新日期:1999-01-01 00:00:00
abstract::All available English, French, and German literature published prior to January 1978 in which post-sterilization tubal pregnancy was reported was surveyed. From 1957 on, the Index Medicus or Current List of Medical Literature was surveyed for reported sterilization failures. Additional references cited in the litera...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-197907010-00029
更新日期:1979-07-01 00:00:00
abstract::Ectopic pregnancy accounts for 2 percent of all pregnancies in the United States, and contributes substantially to maternal morbidity and mortality. Risk factors for the development of ectopic pregnancy are described, but less than 50 percent of women with ectopic pregnancy actually give a history of such risk factors...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199805000-00024
更新日期:1998-05-01 00:00:00