Thrombophilia screening in pregnancy.

Abstract:

UNLABELLED:Thromboembolism in pregnancy is a major contributor to pregnancy morbidity and mortality with potentially serious adverse effects for both mother and fetus. The purposes of this article are to explore the impact of heritable and acquired thrombophilias on pregnancy and to determine the appropriateness of screening for thrombophilias in pregnancy. In determining the appropriateness of screening, attention was given to the changes that occur in the coagulation and fibrinolytic systems during normal pregnancy. The impact of different heritable and acquired thrombophilias on maternal venous thromboembolism, fetal loss, and its impact on certain obstetric conditions are then explored. Guidelines and conclusions are made as to the appropriateness of screening. TARGET AUDIENCE:Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES:After completion of this article, the reader should be able to list the various thrombophilias associate with pregnancy, to describe the impact of thrombophilias on pregnancy, and to outline the appropriate screening guidelines for thrombophilias during pregnancy.

journal_name

Obstet Gynecol Surv

authors

Jordaan DJ,Schoon MG,Badenhorst PN

doi

10.1097/01.ogx.0000165116.96026.4e

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

394-404

issue

6

eissn

0029-7828

issn

1533-9866

pii

00006254-200506000-00026

journal_volume

60

pub_type

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