Abstract:
:Understanding molecular biology can improve the clinical acumen of the practicing obstetrician/gynecologist. An area of basic research now becoming clinically relevant involves the G proteins and G protein-coupled receptors. Clinicians already manipulate G protein-coupled receptors in their daily practice. Examples include the administration of oxytocin (oxytocin receptors), beta-2 tocolytic agents (beta 2-adrenergic receptors), GnRH agonists (GnRH receptors), exogenous gonadotropins (FSH and LH receptors), and bromocriptine (dopamine receptor). Clinically important disorders presenting to the obstetrician/gynecologist include some forms of precocious puberty, delayed puberty, premature ovarian failure, and pituitary adenomas which are due to mutations of G proteins and G protein-coupled receptors. The importance of these proteins is demonstrated by the fact that G protein-related genes comprise about 1 percent of the human genome. Additionally, the knowledge that some G protein gene mutations are present in the germ line, and others are somatic cell in origin (and not heritable), aids in more accurate genetic counseling to patients.
journal_name
Obstet Gynecol Survjournal_title
Obstetrical & gynecological surveyauthors
Cohen DP,Layman LCdoi
10.1097/00006254-199701000-00025subject
Has Abstractpub_date
1997-01-01 00:00:00pages
73-80issue
1eissn
0029-7828issn
1533-9866journal_volume
52pub_type
杂志文章,评审abstract::Medical abortion is a safe, convenient, and effective method for terminating an early unintended pregnancy. Medical abortion can be performed up to 63 days from the last menstrual period and may even be used up to 70 days for women who prefer medical abortion over surgical abortion. Counseling on the adverse effects a...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000017
更新日期:2014-01-01 00:00:00
abstract::In the late 1980s and early 1990s, researchers hypothesized that aspirin could be used to prevent or delay the onset of preeclampsia. This hypothesis was tested in numerous trials which showed limited, but positive results. Subsequently, aspirin has been used in an attempt to improve pregnancy outcomes in women who ha...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e31815e8731
更新日期:2008-01-01 00:00:00
abstract::Fibromatosis is a benign, infiltrating, nonmetastasizing neoplasm which is rarely completely resected. Therefore, the incidence of recurrence is high. Fibromatosis is more common in females and is frequently diagnosed during pregnancy. Inasmuch as fibromatosis of the female pelvis appears to be a discrete entity, mana...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-198905000-00012
更新日期:1989-05-01 00:00:00
abstract:UNLABELLED:Insulinomas are rare tumors with an incidence of approximately four cases per million person-years. Nineteen cases of insulinoma during pregnancy have been reported. Hypoglycemic symptoms usually appear during the first trimester. A 28-year-old primigravida was admitted at 6 weeks of gestation after referral...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200204000-00022
更新日期:2002-04-01 00:00:00
abstract::We analyzed the associations of colposcopic features with cervical and vaginal pathogens and with clinical diagnoses in randomly selected women attending a clinic for sexually transmitted diseases. Logistic regression models were used to adjust for coinfections. Significant associations (P less than 0.01) were found f...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/00006254-198807000-00001
更新日期:1988-07-01 00:00:00
abstract::Although the etiology of preterm premature rupture of membranes (PPROM) is probably multifactorial, recent literature has indicated that infectious processes may play an important role. The management of PPROM is still controversial, requiring individualization of care for each patient. Expectant management is increas...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199308000-00026
更新日期:1993-08-01 00:00:00
abstract::This review first makes some general comments about prophylactic antibiotics: animal models for antimicrobial prophylaxis, bacterial flora of the female genital tract, timing and duration of prophylactic antibiotic administration, and drug of choice for prophylaxis. Subsequent sections cover the following: prophyla...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-198409000-00001
更新日期:1984-09-01 00:00:00
abstract:Importance:Adequate management of menstrual hygiene is taken for granted in affluent countries; however, inadequate menstrual hygiene is a major problem for girls and women in resource-poor countries, which adversely affects the health and development of adolescent girls. Objective:The aim of this article is to review...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000443
更新日期:2017-06-01 00:00:00
abstract::Pregnancy complicated by a thermal injury must be aggressively managed to provide a favorable outcome for the mother and her developing fetus. The MEDLINE database was used to search for English-language papers published after 1980 to evaluate the classification, complications, and treatment of thermal injuries in pre...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199801000-00024
更新日期:1998-01-01 00:00:00
abstract::Rectus sheath hematoma (RSH) is a rare, but important potential cause of acute upper abdominal pain in pregnancy. We report a patient with history of hemolysis, elevated liver enzymes, low platelets syndrome who presented with upper abdominal pain, hypotension, elevated hepatic transaminase levels, and a visibly enlar...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e3181f87eaf
更新日期:2010-08-01 00:00:00
abstract:Importance:Vaginal birth after previous cesarean birth (VBAC) is a reasonable option for many women with previous cesarean delivery. Objective:The aim of this study was to summarize evidence and compare recommendations from national guidelines regarding VBAC. Evidence Acquisition:A descriptive review of 3 national gu...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/OGX.0000000000000596
更新日期:2018-09-01 00:00:00
abstract::Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy. This review aimed to explore the mechanisms of action of the quinolone...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000122
更新日期:2014-11-01 00:00:00
abstract::Anesthesia and surgery interfere with normal thermoregulation, and nearly all patients will become hypothermic unless compensatory measures are used. Preoperative patient warming and intraoperative methods using forced air and warmed intravenous fluids are important methods for maintaining patient's core temperature d...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0b013e3182605ccd
更新日期:2012-07-01 00:00:00
abstract::The objective of this study was to review the body of literature in reference to ureteral injury during laparoscopic surgeries and to determine: 1) the reported rates of ureteral injury; 2) the initial laparoscopic surgeries during which ureteral injury occurred; 3) the time of injury recognition (intra- versus postop...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.OGX.0000097781.79401.0B
更新日期:2003-12-01 00:00:00
abstract::For a majority of women, nausea and vomiting of pregnancy (NVP) is an unpleasant but normal feature of pregnancy. NVP has a largely unknown etiology, but it is widely agreed that physiological, psychological, genetic, and cultural components are contributing factors. The occurrence of NVP may be of benefit in pregnanc...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200112000-00004
更新日期:2001-12-01 00:00:00
abstract::This paper discusses the various methods used to diagnose uterine perforation caused by an IUD. Radiography, or plain film, has a limited use in the diagnosis of uterine perforation since its usefulness depends on the radiopacity of the particular IUD; if the IUD appears on film, plain film does not allow one to conc...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-198108000-00001
更新日期:1981-08-01 00:00:00
abstract::Viral venereal infection caused by human Papillomavirus has reached epidemic state. The proper management of this infection in men is of great benefit, because it may possibly decrease the reservoir of disease in both sexes from which genital condylomata and associated lesions may arise. We report a selection of curre...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:
更新日期:1994-11-01 00:00:00
abstract::The goal of this manuscript is to review the contemporary evidence on issues pertinent to improving the safety profile of vaginal birth after cesarean (VBAC) attempts. Patients attempting VBAC have success rates of 60%-80%, and no reliable method of predicting VBAC failure for individual patients exists. The rate of u...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/OGX.0b013e31817f1505
更新日期:2008-08-01 00:00:00
abstract::Although pregnancy in renal transplant patients was looked upon with skepticism in the past, it is no longer an insurmountable barrier to successful pregnancy. Gestation in these patients, once quite rare, is increasing markedly and obstetricians expect to encounter problems such as immunologic, genetic, teratogenic, ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-198605000-00002
更新日期:1986-05-01 00:00:00
abstract::The effect of progestogens on endometrium depends on the dosage, duration of exposure, the type of progestogen, and the presence or absence of estrogen. Mechanisms of progestogen action in endometrium are mainly expressed through the binding of hormone to specific nuclear receptors. Exogenous progestogens seem to infl...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199505000-00026
更新日期:1995-05-01 00:00:00
abstract::Porencephaly may result from either a developmental anomaly or an antepartum intraparenchymal insult. Pre- and postnatal ultrasonography can demonstrate characteristic images of porencephaly. There is minimal literature on diagnosis and outcome of antenatally diagnosed porencephaly. There are two types of porencephaly...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199509000-00023
更新日期:1995-09-01 00:00:00
abstract:Importance:Uterine torsion is an uncommon but life-threatening clinical situation that requires a high index of suspicion for diagnosis. Objective:The aim of this study was to review literature and determine the etiology, presentation, diagnosis, and management of uterine torsion in the gravid and nongravid patients. ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000767
更新日期:2020-04-01 00:00:00
abstract::Approximately one in four women will experience a miscarriage during her lifetime. For more than 50 years, the standard management of early pregnancy failure has been a dilatation and curettage (D & C). Typically, the procedure is performed in an operating room, which significantly increases cost. There is little obje...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200102000-00024
更新日期:2001-02-01 00:00:00
abstract::5 cases of vascular complications--hemorrhagic stroke, myocardial infarction, retinal vein thrombosis, thrombotic stroke and deep vein thrombosis--in young women taking low dose oral contraceptives are described from the Department of Obstetrics and Gynecology, University of the Witwatersrand, Johannesburg, South Afri...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-199009000-00003
更新日期:1990-09-01 00:00:00
abstract:UNLABELLED:Although stem cells have held the fascination of scientists for years, the attention of the general public has recently been captured by the derivation of human embryonic stem cells. In this review we describe the historical experiments leading up to the isolation of human embryonic stem cells and discuss re...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.OGX.0000055204.35328.F3
更新日期:2003-03-01 00:00:00
abstract::This article reviews the literature that evaluates pruritic urticarial papules and plaques of pregnancy, herpes gestationis, and intrahepatic cholestasis of pregnancy and their impact on the fetus. Using MEDLINE years 1966 to 1999, a literature search was performed using the terms pregnancy, dermatology, pruritic urti...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/00006254-200107000-00022
更新日期:2001-07-01 00:00:00
abstract::Preterm delivery presents the main cause of neonatal morbidity and mortality worldwide. The rate of preterm delivery is 12% to 13% in the United States, of which 29% concerns preterm deliveries before 34 weeks of gestation. Basic parameter of prevention strategy is implementation of tocolytic therapy in cases of threa...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/OGX.0000000000000302
更新日期:2016-04-01 00:00:00
abstract::A variegated group of autoimmune disorders tend to occur in women during childbearing years. Autoantibodies, often of IgG type, directed against the mother's (self) antigens has been well characterized in a number of these disorders. Transplacental transfer of IgG autoantibodies has been frequently demonstrated withou...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
abstract:UNLABELLED:Primary pure ovarian leiomyosarcomas constitute a malignant subgroup of ovarian smooth muscle tumors which comprise only 1% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure. Malignant behavior is almost always associated with any 2 of ...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章,评审
doi:10.1097/01.ogx.0000268629.16151.71
更新日期:2007-07-01 00:00:00
abstract::Two recent surveys provide insights into U.S. women's attitudes toward and perceptions of the IUD. The first study was based on in-depth interviews conducted with 300 women 21-54 years of age in 6 cities; the second was based on telephone interviews with 1852 low-income, predominantly Black and Hispanic women 18-34 y...
journal_title:Obstetrical & gynecological survey
pub_type: 杂志文章
doi:10.1097/00006254-199612000-00012
更新日期:1996-12-01 00:00:00