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Effects of cochlear ablation on local cerebral glucose utilization in fetal sheep.

Abstract：

:Local cerebral glucose utilization was measured by the [14C]-deoxyglucose method in five near-term fetal sheep in whom bilateral ablation of the cochleae had been accomplished aseptically 5 to 8 days earlier. The tympanic membrane and ossicles were removed and all turns of each cochlea were unroofed with destruction carried to the modiolus. Mean local cerebral glucose utilization of 33 of 34 gray matter structures and four of four white matter structures in operated animals were significantly lower (p less than 0.05) than that in unoperated control fetuses. The depression in local cerebral glucose utilization was greatest (p less than 0.002) in brain stem auditory nuclei, in which the mean rate of glucose utilization was approximately 25% of the levels in unoperated fetuses. The pattern of glucose utilization in these structures was clearly altered, with a reversal of the normal distribution in density of the inferior colliculus. Tonotopic bands of high local cerebral glucose utilization frequently seen in autoradiographs of inferior colliculus in unoperated fetuses were not observed in operated fetuses. These results show that the glucose utilization of the brain, and by implication the normal growth and maturation of the brain, depends on an intact auditory system during prenatal life.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Abrams RM,Hutchison AA,McTiernan MJ,Merwin GE

doi

10.1016/s0002-9378(87)80240-5

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1438-42

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(87)80240-5

journal_volume

157

pub_type

杂志文章

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