Staging and prognosis of chronic lymphocytic leukemia: the Manitoba experience.

Abstract:

:Three hundred ninety-one cases of chronic lymphocytic leukemia (CLL) from the Tumour Registry of Manitoba, spanning a 20-year period from January 1960 to December 1979, were reviewed. Survival curves were developed using the staging systems of Rai and Binet. A clear separation in survival was found utilizing the system of Binet. Also, there was a significant increase in the development of secondary malignancies (observed, 53; expected, 31, p less than 0.01). However, there was no significant increase in secondary malignancies if only those malignancies occurring at least six months after the diagnosis of chronic lymphocytic leukemia was made were analyzed (observed, 38; expected, 29, p = 0.26). This suggests that the increase in secondary malignancies is not treatment-related, and may be due to the underlying disease.

journal_name

J Gen Intern Med

authors

MacDougall BK,Weinerman BH

doi

10.1007/BF02596118

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

139-43

issue

2

eissn

0884-8734

issn

1525-1497

journal_volume

3

pub_type

杂志文章
  • Racial differences in blood pressure control: potential explanatory factors.

    abstract:OBJECTIVE:The objective of the study was to identify potential explanatory factors for racial differences in blood pressure (BP) control. DESIGN:The design of the study was a cross-sectional study PATIENTS/PARTICIPANTS:The study included 608 patients with hypertension who were either African American (50%) or white (...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11606-008-0547-7

    authors: Bosworth HB,Powers B,Grubber JM,Thorpe CT,Olsen MK,Orr M,Oddone EZ

    更新日期:2008-05-01 00:00:00

  • Brief report: Use and misuse of thyroid ultrasound in the initial workup of patients with suspected thyroid problems referred by primary care physicians to an endocrine clinic.

    abstract:BACKGROUND AND OBJECTIVES:Thyroid ultrasound (TUS) plays an important but limited role in the evaluation of some complaints related to the thyroid gland. This study was designed to examine how primary care physicians use TUS before referring patients to an endocrine clinic. DESIGN:We audited all charts of first-time r...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1525-1497.2005.0124.x

    authors: Liel Y,Fraenkel N

    更新日期:2005-08-01 00:00:00

  • Correction to: Do Words Matter? Stigmatizing Language and the Transmission of Bias in the Medical Record.

    abstract::In the HTML version of this paper, Ms. Goddu was incorrectly listed. The correct citation should be AP Goddu. Exposure to the stigmatizing language note was associated with more negative attitudes towards the patient (20.3 stigmatizing vs. 25.1 neutral, p < 0.001). Reading the stigmatizing language note was associated...

    journal_title:Journal of general internal medicine

    pub_type: 已发布勘误

    doi:10.1007/s11606-018-4583-7

    authors: Goddu AP,O'Conor KJ,Lanzkron S,Saheed MO,Saha S,Peek ME,Haywood C Jr,Beach MC

    更新日期:2019-01-01 00:00:00

  • Relationship between conflicts of interest and research results.

    abstract:CONTEXT:To date, research regarding the influence of conflicts of interest on the presentation of findings by researchers has been limited. OBJECTIVE:To evaluate the sources of funding for published manuscripts, and association between reported findings and conflicts of interest. METHODS:Data from both print and elec...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1525-1497.2004.30617.x

    authors: Friedman LS,Richter ED

    更新日期:2004-01-01 00:00:00

  • A workshop to teach medical students communication skills and clinical knowledge about end-of-life care.

    abstract::We describe a half-day workshop to teach third-year medical students three focused end-of-life care skills: breaking bad news, discussing advance directives, and assessing and managing pain. Our workshop included a readers' theater exercise and three role-play exercises. In two of the workshops, faculty members played...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1525-1497.2004.30115.x

    authors: Torke AM,Quest TE,Kinlaw K,Eley JW,Branch WT Jr

    更新日期:2004-05-01 00:00:00

  • Provider responses to patients controlling access to their electronic health records: a prospective cohort study in primary care.

    abstract:INTRODUCTION:Applying Fair Information Practice principles to electronic health records (EHRs) requires allowing patient control over who views their data. METHODS:We designed a program that captures patients' preferences for provider access to an urban health system's EHR. Patients could allow or restrict providers' ...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-014-3053-0

    authors: Tierney WM,Alpert SA,Byrket A,Caine K,Leventhal JC,Meslin EM,Schwartz PH

    更新日期:2015-01-01 00:00:00

  • The impact of the Medicare Part D prescription benefit on generic drug use.

    abstract:BACKGROUND:Little information exists regarding the impact of Medicare Part D on generic drug use. OBJECTIVE:To examine changes in the use of generic prescriptions attributable to Part D among a sample of Medicare beneficiaries. DESIGN, PARTICIPANTS, AND MEASUREMENTS:Difference-in-difference analysis of pharmacy claim...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-008-0742-6

    authors: Zhang JX,Yin W,Sun SX,Alexander GC

    更新日期:2008-10-01 00:00:00

  • Administrator Perspectives on ICU-to-Ward Transfers and Content Contained in Existing Transfer Tools: a Cross-sectional Survey.

    abstract:BACKGROUND:The transfer of critically ill patients from the intensive care unit (ICU) to hospital ward is challenging. Shortcomings in the delivery of care for patients transferred from the ICU have been associated with higher healthcare costs and poor satisfaction with care. Little is known about how hospital ward pro...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11606-018-4590-8

    authors: Boyd JM,Roberts DJ,Parsons Leigh J,Stelfox HT

    更新日期:2018-10-01 00:00:00

  • Impact of Pregnancy and Gender on Internal Medicine Resident Evaluations: A Retrospective Cohort Study.

    abstract:BACKGROUND:Pregnancy and its impact on graduate medical training are not well understood. OBJECTIVE:To examine the effect of gender and pregnancy for Internal Medicine (IM) residents on evaluations by peers and faculty. DESIGN:This was a retrospective cohort study. SUBJECTS:All IM residents in training from July 1, ...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-017-4010-5

    authors: Krause ML,Elrashidi MY,Halvorsen AJ,McDonald FS,Oxentenko AS

    更新日期:2017-06-01 00:00:00

  • Characterizing Potentially Preventable Admissions: A Mixed Methods Study of Rates, Associated Factors, Outcomes, and Physician Decision-Making.

    abstract:BACKGROUND:Potentially preventable admissions are a target for healthcare cost containment. OBJECTIVE:To identify rates of, characterize associations with, and explore physician decision-making around potentially preventable admissions. DESIGN:A comparative cohort study was used to determine rates of potentially prev...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-017-4285-6

    authors: Daniels LM,Sorita A,Kashiwagi DT,Okubo M,Small E,Polley EC,Sawatsky AP

    更新日期:2018-05-01 00:00:00

  • A Coaching by Telephone Intervention on Engaging Patients to Address Modifiable Cardiovascular Risk Factors: a Randomized Controlled Trial.

    abstract:BACKGROUND:A large proportion of deaths and chronic illnesses can be attributed to three modifiable risk factors: tobacco use, overweight/obesity, and physical inactivity. OBJECTIVE:To test whether telephone-based health coaching after completion of a comprehensive health risk assessment (HRA) increases patient activa...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11606-018-4398-6

    authors: Oddone EZ,Gierisch JM,Sanders LL,Fagerlin A,Sparks J,McCant F,May C,Olsen MK,Damschroder LJ

    更新日期:2018-09-01 00:00:00

  • Mortality, symptoms, and functional impairment in late-life depression.

    abstract:OBJECTIVE:To determine whether depressive symptoms measured at baseline are associated with mortality and to describe the course of depressive symptoms and their relation to physical decline in patients over a 6-year period. DESIGN:Prospective cohort study conducted from 1990 through 1996. SETTING:Urban academic prim...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1046/j.1525-1497.1998.00226.x

    authors: Callahan CM,Wolinsky FD,Stump TE,Nienaber NA,Hui SL,Tierney WM

    更新日期:1998-11-01 00:00:00

  • Agreement of four competing guidelines on prevention of venous thromboembolism and comparison with observed physician practices: a cross-sectional study of 1,032 medical inpatients.

    abstract:OBJECTIVE:To assess the degree of agreement between four competing guidelines regarding the recommendation for prophylactic heparin therapy and to report to what extent actual practice agreed with or differed from the recommendations made before these guidelines were disseminated. DESIGN:Four French guidelines were ap...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1525-1497.2004.30603.x

    authors: Labarère J,Bosson JL,Bergmann JF,Thilly N

    更新日期:2004-08-01 00:00:00

  • Potentially Preventable Spending Among High-Cost Medicare Patients: Implications for Healthcare Delivery.

    abstract:BACKGROUND:High-cost patients account for a disproportionate share of healthcare spending. The proportion and distribution of potentially preventable spending among subgroups of high-cost patients are largely unknown. OBJECTIVE:To examine the distribution of potentially preventable spending among high-cost Medicare pa...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-020-05691-8

    authors: Khullar D,Zhang Y,Kaushal R

    更新日期:2020-10-01 00:00:00

  • Improving Rates of Outpatient Influenza Vaccination Through EHR Portal Messages and Interactive Automated Calls: A Randomized Controlled Trial.

    abstract:BACKGROUND:Patient reminders for influenza vaccination, delivered via electronic health record (EHR) patient portal messages and interactive voice response (IVR) calls, offer an innovative approach to improving patient care. OBJECTIVE:To test the effectiveness of portal and IVR outreach in improving rates of influenza...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11606-017-4266-9

    authors: Cutrona SL,Golden JG,Goff SL,Ogarek J,Barton B,Fisher L,Preusse P,Sundaresan D,Garber L,Mazor KM

    更新日期:2018-05-01 00:00:00

  • Effects of a Specialized Primary Care Facility on Preventive Service Use Among Autistic Adults: a Retrospective Claims Study.

    abstract:BACKGROUND:While in some studies, the patient-centered medical home has been linked with increased receipt of preventive services among other populations, there is a paucity of literature testing the effectiveness of medical homes in serving the healthcare needs of autistic adults. OBJECTIVE:To compare the receipt of ...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-020-06513-7

    authors: Hand BN,Gilmore D,Coury DL,Darragh AR,Moffatt-Bruce S,Hanks C,Garvin JH

    更新日期:2021-01-19 00:00:00

  • Impact of an Overnight Internal Medicine Academic Hospitalist Program on Patient Outcomes.

    abstract:BACKGROUND:Many academic hospitals have implemented overnight hospitalists to supervise house staff and improve outcomes, but few studies have described the impact of this role. OBJECTIVE:To investigate the effect of an overnight academic hospitalist program on patient-level outcomes. Secondary objectives were to desc...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-015-3389-0

    authors: Gonzalo JD,Kuperman EF,Chuang CH,Lehman E,Glasser F,Abendroth T

    更新日期:2015-12-01 00:00:00

  • Association Between Opioid Dose Reduction Against Patients' Wishes and Change in Pain Severity.

    abstract:BACKGROUND:There is inadequate evidence of long-term benefit from opioid medications for chronic pain and substantial evidence of potential harms. For patients, dose reduction may be beneficial when implemented voluntarily and supported by a multidisciplinary team but experts have advised against involuntary opioid red...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-020-06294-z

    authors: Frank JW,Carey E,Nolan C,Hale A,Nugent S,Krebs EE

    更新日期:2020-12-01 00:00:00

  • Variation in Inpatient Consultation Among Older Adults in the United States.

    abstract:BACKGROUND:Differences among hospitals in the use of inpatient consultation may contribute to variation in outcomes and costs for hospitalized patients, but basic epidemiologic data on consultations nationally are lacking. OBJECTIVE:The purpose of the study was to identify physician, hospital, and geographic factors t...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-015-3216-7

    authors: Stevens JP,Nyweide D,Maresh S,Zaslavsky A,Shrank W,Howell MD,Landon BE

    更新日期:2015-07-01 00:00:00

  • A Model of Organizational Context and Shared Decision Making: Application to LGBT Racial and Ethnic Minority Patients.

    abstract::Shared decision making (SDM) occurs when patients and clinicians work together to reach care decisions that are both medically sound and responsive to patients' preferences and values. SDM is an important tenet of patient-centered care that can improve patient outcomes. Patients with multiple minority identities, such...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-016-3608-3

    authors: DeMeester RH,Lopez FY,Moore JE,Cook SC,Chin MH

    更新日期:2016-06-01 00:00:00

  • Suspected pulmonary embolism and lung scan interpretation: trial of a Bayesian reporting method.

    abstract:OBJECTIVE:To determine whether a Bayesian method of lung scan (LS) reporting could influence the management of patients with suspected pulmonary embolism (PE). DESIGN:1) A descriptive study of the diagnostic process for suspected PE using the new reporting method; 2) a non-experimental evaluation of the reporting meth...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/BF02600392

    authors: Becker DM,Philbrick JT,Schoonover FW,Teates CD

    更新日期:1990-07-01 00:00:00

  • Impact of a randomized controlled educational trial to improve physician practice behaviors around screening for inherited breast cancer.

    abstract:BACKGROUND:Many primary care physicians (PCPs) are ill-equipped to provide screening and counseling for inherited breast cancer. OBJECTIVE:To evaluate the outcomes of an interactive web-based genetics curriculum versus text curriculum for primary care physicians. DESIGN:Randomized two-group design. PARTICIPANTS:121 ...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11606-014-3113-5

    authors: Bell RA,McDermott H,Fancher TL,Green MJ,Day FC,Wilkes MS

    更新日期:2015-03-01 00:00:00

  • Persistent Severe Fixed Airways Obstruction in a High-Dosing E-cigarette User.

    abstract::Electronic Nicotine Delivery Systems (ENDS), commonly referred to as "e-cigs," were first introduced in the United States in 2007. Since then, their use has grown substantially, with the largest market among adolescents and young adults. ENDS are often perceived by the public as safe alternatives to traditional cigare...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-019-05462-0

    authors: Macedonia TV,Krefft SD,Rose CS

    更新日期:2020-01-01 00:00:00

  • Buprenorphine retention in primary care.

    abstract:BACKGROUND:This study assesses the rate and predictors of treatment retention for primary care patients with opioid dependence-prescribed buprenorphine, a long-acting partial opioid agonist. METHODS:Observational cohort study of patients prescribed buprenorphine/naloxone and followed for 6 months in the period after t...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1111/j.1525-1497.2005.0228.x

    authors: Stein MD,Cioe P,Friedmann PD

    更新日期:2005-11-01 00:00:00

  • Impact of Procalcitonin Guidance on Management of Adults Hospitalized with Chronic Obstructive Pulmonary Disease Exacerbations.

    abstract:BACKGROUND:Antibiotics are often prescribed for hospitalized patients with chronic obstructive pulmonary disease (COPD) exacerbations. The use of procalcitonin (PCT) in the management of pneumonia has safely reduced antibiotic durations, but limited data on the impact of PCT guidance on the management of COPD exacerbat...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-018-4312-2

    authors: Bremmer DN,DiSilvio BE,Hammer C,Beg M,Vishwanathan S,Speredelozzi D,Moffa MA,Hu K,Abdulmassih R,Makadia JT,Sandhu R,Naddour M,Chan-Tompkins NH,Trienski TL,Watson C,Obringer TJ,Kuzyck J,Walsh TL

    更新日期:2018-05-01 00:00:00

  • Treating depression in staff-model versus network-model managed care organizations.

    abstract:OBJECTIVE:To compare primary care providers' depression-related knowledge, attitudes, and practices and to understand how these reports vary for providers in staff or group-model managed care organizations (MCOs) compared with network-model MCOs including independent practice associations and preferred provider organiz...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1046/j.1525-1497.1999.00279.x

    authors: Meredith LS,Rubenstein LV,Rost K,Ford DE,Gordon N,Nutting P,Camp P,Wells KB

    更新日期:1999-01-01 00:00:00

  • Are opioid dependence and methadone maintenance treatment (MMT) documented in the medical record? A patient safety issue.

    abstract:BACKGROUND:Opioid-dependent patients often have co-occurring chronic illnesses requiring medications that interact with methadone. Methadone maintenance treatment (MMT) is typically provided separately from medical care. Hence, coordination of medical care and substance use treatment is important to preserve patient sa...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-009-1043-4

    authors: Walley AY,Farrar D,Cheng DM,Alford DP,Samet JH

    更新日期:2009-09-01 00:00:00

  • A transitional opioid program to engage hospitalized drug users.

    abstract:BACKGROUND:Many opioid-dependent patients do not receive care for addiction issues when hospitalized for other medical problems. Based on 3 years of clinical practice, we report the Transitional Opioid Program (TOP) experience using hospitalization as a "reachable moment" to identify and link opioid-dependent persons t...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-010-1311-3

    authors: Shanahan CW,Beers D,Alford DP,Brigandi E,Samet JH

    更新日期:2010-08-01 00:00:00

  • Weight loss success in metabolic syndrome by telephone interventions: results from the SHINE Study.

    abstract:BACKGROUND:The Diabetes Prevention Program (DPP) intensive lifestyle intervention resulted in significant weight loss, reducing the development of diabetes, but needs to be adapted to primary care provider (PCP) practices. OBJECTIVES:To compare a DPP-translation using individual (IC) vs. conference (CC) calls delivere...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s11606-013-2529-7

    authors: Weinstock RS,Trief PM,Cibula D,Morin PC,Delahanty LM

    更新日期:2013-12-01 00:00:00

  • Dense Breast Notification Laws, Education, and Women's Awareness and Knowledge of Breast Density: a Nationally Representative Survey.

    abstract:BACKGROUND:To date, 38 states have enacted dense breast notification (DBN) laws mandating that mammogram reports include language informing women of risks related to dense breast tissue. OBJECTIVE:Nationally representative survey to assess the association between residing in a state with a DBN law and women's awarenes...

    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/s11606-019-05590-7

    authors: Kyanko KA,Hoag J,Busch SH,Aminawung JA,Xu X,Richman IB,Gross CP

    更新日期:2020-07-01 00:00:00