Abstract:
:Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Reddy BG,Silk JD,Salio M,Balamurugan R,Shepherd D,Ritter G,Cerundolo V,Schmidt RRdoi
10.1002/cmdc.200800354subject
Has Abstractpub_date
2009-02-01 00:00:00pages
171-5issue
2eissn
1860-7179issn
1860-7187journal_volume
4pub_type
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