Abstract:
:Into the fold: Prion diseases are neurodegenerative disorders characterized by the accumulation in the brain of a self-replicating, misfolded isoform (PrPSc ) of the cellular prion protein (PrPC ). No therapies are available for these pathologies. We capitalized on previously described cell-based assays to screen a library of small molecules, and identified 55, a compound capable of counteracting both prion replication and toxicity. Compound 55 may represent the starting point for the development of a completely new class of therapeutics for prion diseases.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Massignan T,Sangiovanni V,Biggi S,Stincardini C,Elezgarai SR,Maietta G,Andreev IA,Ratmanova NK,Belov DS,Lukyanenko ER,Belov GM,Barreca ML,Altieri A,Kurkin AV,Biasini Edoi
10.1002/cmdc.201700302subject
Has Abstractpub_date
2017-08-22 00:00:00pages
1286-1292issue
16eissn
1860-7179issn
1860-7187journal_volume
12pub_type
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