Abstract:
PURPOSE:Pretreating the kidney with 100 low energy SWs with a time pause before delivering a clinical dose of SWs (Dornier HM-3, 2000 SWs, 24 kV, 120 SWs/min) has been shown to significantly reduce the size of the hemorrhagic lesion produced in that treated kidney, compared to a protocol without pretreatment. It has been assumed that a similar reduction in injury will occur with lithotripters other than the HM-3, but experiments to confirm this assumption are lacking. In this study we sought to verify that the lesion protection phenomenon also occurs in a lithotripter using an electromagnetic shock source and dry-head coupling. MATERIALS AND METHODS:Eleven female pigs were placed in a Dornier Compact S lithotripter where the left kidney of each animal was targeted for lithotripsy treatment. Some kidneys received 2500 SWs at PL=5 (120 SWs/min) while some kidneys were pretreated with 100 SWs at PL=1, with a 3-minute time pause, followed immediately by 2500 SWs at PL=5 (120 SWs/min). Lesion size analysis was performed to assess the volume of hemorrhagic tissue injury created by each treatment regimen (% FRV). RESULTS:Lesion size fell by 85% (P=0.01) in the 100 SW pretreatment group compared to the injury produced by a regimen without pretreatment. CONCLUSIONS:The results suggest that the treatment pause protection phenomenon occurs with a Dornier Compact S, a machine distinctly different from the Dornier HM-3. This result also suggests that this phenomenon may be observed generally in SW lithotripters.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Connors BA,Gardner A,Liu Z,Lingeman JE,Williams JC Jrdoi
10.1089/end.2020.0681subject
Has Abstractpub_date
2021-01-20 00:00:00eissn
0892-7790issn
1557-900Xpub_type
杂志文章abstract:: Aims: To compare outcomes of monopolar vs bipolar transurethral resection of the prostate (TURP) in the management of exclusively moderate-large volume prostatic hyperplasia in terms of maximum flow rate as a surrogate for clinical efficacy, duration of catheterization, ho...
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