Abstract:
: Objective: To evaluate the safety of irreversible electroporation (IRE) for renal ablation adjacent to the ureter or bowel. Materials and Methods: Six adult pigs each underwent bilateral IRE of the kidney. To simulate adjacence, the left proximal ureter and duodenum were secured onto the left and right kidney capsule, respectively. Two IRE probes were placed into the renal parenchyma and configured to bridge the ureter and bowel. Therapeutic IRE was delivered at 2000 V/cm for 70 pulses in both forward and reverse polarity. The animal was survived and euthanized at 1, 3, or 14 days. Histopathology was obtained for all potentially injured bowel and ureteral segments. Retrograde pyelogram (RPG) was performed on each left-sided ureter. Results: Histologic analysis of the ureter identified reactive changes at the level of the periureteral adipose tissue, which progressed from acute inflammation on day 1 to focal fibrosis by day 14. Urothelial mucosa and surrounding smooth muscle layers were unaffected at all time points. RPGs did not show any abnormalities in all specimens. Histologic analysis of the bowel demonstrated acute inflammation in the serosa and subserosal tissue on day 1. Three days after IRE, inflammation and crypt abscesses were focally present in the deep aspects of the bowel mucosa. Inflammation in the mucosal layer resolved 14 days after IRE. Conclusions: In a porcine model of renal IRE, no significant injury was apparent after intentional ablation adjacent to the ureter and bowel. IRE may be a safe alternative to thermal ablation for tumors near the ureter or bowel.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Sorokin I,Canvasser N,Johnson B,Lucas E,Cadeddu JAdoi
10.1089/end.2020.0856subject
Has Abstractpub_date
2020-12-17 00:00:00eissn
0892-7790issn
1557-900Xpub_type
杂志文章abstract:OBJECTIVE:Accurate tumor staging in renal cancer is critical for prognostic projections, follow-up schedules, clinical trials and potential systemic therapies. We studied patients undergoing laparoscopic radical nephrectomy (LRN) to determine the extent of upstaging on histopathology evaluation and correlated the clini...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0399
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Symptomatic renal calculi found within caliceal diverticula are difficult to treat. We present a single-surgeon cohort of 21 consecutive patients undergoing percutaneous treatment of stones within caliceal diverticula over a 12-year period. PATIENTS AND METHODS:Each patient was managed by a one-stage percuta...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1999.13.83
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abstract:PURPOSE:We developed a genitourinary skills training (GUST) curriculum for incoming third year medical students (MS3) and performed a follow-up study of comfort with and utilization of these skills. MATERIALS AND METHODS:GUST consisted of a didactic lecture followed by skills sessions including standardized patient te...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2012.0284
更新日期:2012-10-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
doi:10.1089/end.2013.0436
更新日期:2014-02-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.586
更新日期:2006-08-01 00:00:00
abstract::We describe a novel use of near-infrared fluorescence (NIRF) imaging without contrast agents, like indocyanine green, to identify otherwise obscured intraluminal areas of interest during robot-assisted laparoscopic (RAL) surgery marked by the white light (WL) of endoscopic instruments. By filtering light wavelengths b...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0606
更新日期:2014-05-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277903767923227
更新日期:2003-08-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0954
更新日期:2020-12-17 00:00:00
abstract:: Purpose: To examine the dusting performance of a novel solid state Thulium laser device compared to a standard holmium:yttrium-aluminum-garnet (Ho:YAG) device. Methods: This study compares a Dornier Medilas H Solvo 35 with an e...
journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2020-09-09 00:00:00
abstract:: Introduction: There has been a surge in robotic surgery research publications over the past 20 years. However, to date, there has been no characterization of urology's contribution to the robotic field, and there is a lack of bibliometric literature to guide future investi...
journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0204
更新日期:2010-12-01 00:00:00
abstract:: Background: Nonmuscle-invasive bladder cancer is diagnosed, treated, and monitored using cystoscopy. Artificial intelligence (AI) is increasingly used to augment tumor detection, but its performance is hindered by the limited availability of cystoscopic images required to ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0919
更新日期:2020-12-04 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2015.0454
更新日期:2016-01-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2009.0656
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ureteral stents are commonly used in urology today, but the biofilms that form on them within hours of placement may harbor bacteria that can result in infection or encrustation. Triclosan is an antimicrobial commonly used in consumer and medical products that inhibits bacterial fatty-acid synthe...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.949
更新日期:2006-11-01 00:00:00
abstract::Minimal bleeding during endoscopic surgery of the urinary tract may prevent optimum vision. We used neurosurgical patties for dissection during our laparoscopic procedures in the pediatric population and aimed to describe this technique as an alternative to standard ways of dissection during laparoscopic procedures. W...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0435
更新日期:2011-05-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2014.0315
更新日期:2014-11-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2004.18.901
更新日期:2004-11-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0419
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/end.2000.14.451
更新日期:2000-06-01 00:00:00
abstract:: Aims: To compare outcomes of monopolar vs bipolar transurethral resection of the prostate (TURP) in the management of exclusively moderate-large volume prostatic hyperplasia in terms of maximum flow rate as a surrogate for clinical efficacy, duration of catheterization, ho...
journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2020-12-28 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0673
更新日期:2011-02-01 00:00:00