Initial experience with retroperitoneoscopic microwave ablation of clinical T(1a) renal tumors.

Abstract:

PURPOSE:To evaluate the feasibility, safety, and efficacy of retroperitoneoscopic microwave ablation (MWA) for clinical stage T(1a) (cT(1a)) renal tumors. PATIENTS AND METHODS:Consecutive renal cell carcinomas (RCCs) managed since April 2006 with a minimal follow-up of 12 months were included. A total of 23 tumors in 22 patients were managed with laparoscopic MWA. A cooled shaft needle antenna was inserted into the tumor under direct visual guidance. Microwaves were emitted at 50 W for 8 minutes and prolonged as necessary to ensure complete tumor kill. Short-term efficacy was assessed by contrast-enhanced CT at 1, 3, and 6 months, and every 6 months thereafter. RESULTS:Pathologic analysis revealed low-grade clear-cell RCC in all patients. Mean tumor size was 2.8 cm (range 0.9-4.0 cm). Excluding 5 lost patients, the initial ablation was successful in 17 (94.4%) of 18 tumors. One patient with an incomplete ablation lesion under strict surveillance had no evidence of disease progression at 31 months of follow-up. No recurrence was observed at a median follow-up of 20 months (range 12-45 mos). All 17 remaining patients had no clinical or radiographic evidence of disease at last follow-up. In addition, complications were mild and tolerable (18.2%), and there was no significant deterioration of renal function. CONCLUSIONS:Retroperitoneoscopic MWA appears to be a safe and effective technique for cT(1a) RCC in selected patients. Additional follow-up is needed to assess long-term effectiveness.

journal_name

J Endourol

journal_title

Journal of endourology

authors

Bai J,Hu Z,Guan W,Zhuang Q,Wang S,Liu J,Ye Z

doi

10.1089/end.2010.0204

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

2017-22

issue

12

eissn

0892-7790

issn

1557-900X

journal_volume

24

pub_type

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