Abstract:
:Chemoattractants induce cell migration through the activation of a distinct family of structurally related heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors. Over the past few years, several receptors in this family have been identified that recognize different classes of chemoattractants but do not induce cell migration. These atypical "chemoattractant receptors" are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in leukocyte recruitment by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
journal_name
Sci Signaljournal_title
Science signalingauthors
Borroni EM,Bonecchi R,Mantovani A,Locati Mdoi
10.1126/scisignal.259pe10subject
Has Abstractpub_date
2009-02-24 00:00:00pages
pe10issue
59eissn
1945-0877issn
1937-9145pii
2/59/pe10journal_volume
2pub_type
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