Abstract:
:A method is presented for extending the target lipid model (TLM) of narcotic toxicity to polar narcotic chemicals. The proposed polyparameter TLM extends the applicability of the TLM by including polar compounds and removing explicit chemical class corrections. The validity of the model is tested using a data set of 1,687 acute toxicity tests for 42 aquatic species, including fish, amphibians, arthropods, mollusks, polychaetes, coelenterates, protozoans, and algae, and 398 chemicals. The target lipid-water partition coefficient is computed using the Abraham polyparameter model. This replaces use of the octanol-water partition coefficient so that the partitioning of polar narcotic chemicals can be described correctly. The model predicts the log median lethal concentration with a root mean square error of 0.460 for nonpolar and polar chemicals and 0.501 for only polar chemicals.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Kipka U,Di Toro DMdoi
10.1897/08-364.1subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1429-38issue
7eissn
0730-7268issn
1552-8618pii
08-364journal_volume
28pub_type
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