Early glucometabolic profile in patients with acute coronary syndromes and metabolic syndrome.

Abstract:

BACKGROUND:Patients with metabolic syndrome (MetS) are at high coronary risk and beta-cell dysfunction or insulin resistance might predict an additional risk for early cardiovascular events. OBJECTIVE:This study aimed to evaluate early glucometabolic alterations in patients with MetS, but without previously known type 2 diabetes, after acute coronary syndrome. METHODS:A total of 114 patients were submitted to an oral glucose tolerance test (OGTT) 1-3 days after hospital discharge due to myocardial infarction or unstable angina. Based on the OGTT, we defined three groups of patients: normal glucose tolerance (NGT; n=26), impaired glucose tolerance (IGT; n=39), or diabetes (DM; n=49). The homeostasis model assessment (HOMA-IR) was used to measure insulin resistance; beta-cell responsiveness was assessed by the insulinogenic index at 30 min (DeltaI30/DeltaG30). RESULTS:Based on the HOMA-IR, patients with DM were more insulin-resistant than those with NGT or IGT (p<0.001). According to the insulinogenic index, the beta-cell responsiveness was also impaired in subjects with DM (p<0.001 vs NGT or IGT). CONCLUSION:High rates of glucometabolic alterations were found after acute coronary syndrome in patients with MetS. As these abnormalities markedly increase the risk for adverse outcomes, early OGTT among MetS patients might be used to identify those at the highest coronary risk.

journal_name

Arq Bras Cardiol

authors

Monteiro CM,Oliveira L,Izar MC,Helfenstein T,Santos AO,Fischer SM,Barros SW,Pinheiro LF,Carvalho AC,Fonseca FA

doi

10.1590/s0066-782x2009000200004

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

89-99

issue

2

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2009000200004

journal_volume

92

pub_type

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